[Changes in some metabolic pathways in women ingesting progestagens as contraceptives]. / Zmiany w niektórych metabolizmach ustrojowych kobiet stosujacych preparaty gestagenowe dla celów antykoncepcyjnych

PIP: Literature concerning the changes caused in lipids and protein metabolism in women using gestagen preparations for contraceptive purposes is surveyed. The level of metabolic changes was found to be related to the estrogen content of the preparation. Lipid metabolism changes are in the form of increases in the total lipids in the serum, insignificant increases in the beta-lipoproteins, and increases in the total cholesterol concentrations. The preparations Femigen-Polfa and Anacyclin were not found to increase the total cholesterol concentrations in the pre beta and beta lipoprotein fractions. There is a possible effect on the triglyceride concentrations. Gestagens are assumed to cause changes in the blood serum protein fractions characterized by an increase in the alpha-1, alpha-2, and beta globulins. Concentrational and transportational changes are caused by decrease of the erythrocytes and resin test values and increase in the thyroid hormone binding globulins with a collateral normal concentration of free thyroxine and normal index of free thyroxine. These changes are observed only with the use of estrogen preparations.^ieng