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BACKGROUND: Recently, research data are increasingly shared through social media and other digital platforms. Traditionally, the influence of a scientific article has been assessed by the publishing journal's impact factor (IF) and its citation count. The Altmetric scoring system, a new bibliometric that integrates research "mentions" over digital media platforms, has emerged as a metric of online research distribution. The aim of this study was to explore the relationship of the Altmetric Score with IF and citation number within the pathology literature. METHODS: Citation count and Altmetric scores were obtained from the top 10 most-cited articles from the 15 pathology journals with the highest IF for 2013 and 2016. These variables were analyzed and correlated with each other, as well as the age of the publishing journal's Twitter account. RESULTS: Three hundred articles were examined from the two cohorts. The total citation count of the articles decreased from 21,043 (2013) to 14,679 (2016), while the total Altmetric score increased from 830 (2013) to 4066 (2016). In 2013, Altmetric score weakly correlated with citation number (r = 0.284, P < 0.001) but not with journal IF (r = 0.024, P = 0.771). In 2016, there was strong correlation between citation count and Altmetric Score (r = 0.714, P < 0.0001) but not the IF (r = 0.0442, P = 0.591). Twitter was the single most important contributor to the Altmetric score; however, the age of the Twitter account was not associated with citation number nor Altmetric score. CONCLUSIONS: In the pathology literature studied, the Altmetric score correlates with article citation count, suggesting that the Altmetric score and conventional bibliometrics can be treated as complementary metrics. Given the trend towards increasing use of social media, additional investigation is warranted to evaluate the evolving role of social media metrics to assess the dissemination and impact of scientific findings in the field of pathology.
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CONTEXT.: Current health care spending is unsustainable, and there is a need to teach high-value care principles to future physicians. Pathology-Teaches is an educational intervention designed to teach laboratory stewardship early in clinical training, at the level of the medical student in their core clinical clerkships. OBJECTIVE.: To assess the pilot implementation of case-based educational modules in 5 required core clerkships at our institution. DESIGN.: The online cases were developed by using a multidisciplinary approach. In the Pathology-Teaches educational module, students make decisions regarding the ordering or interpretation of laboratory testing within the context of a clinical scenario and receive immediate feedback during the case. The intervention was assessed by using pretest and posttest. Student feedback was also collected from end-of-rotation evaluations. RESULTS.: A total of 203 students completed the Pathology-Teaches pilot, including 72 in Family Medicine, 72 in Emergency Medicine, 24 in Internal Medicine, 24 in Neurology, and 11 in Obstetrics-Gynecology (OB-GYN). Pathology-Teaches utility was demonstrated by significantly increased improvement between pretest and posttest scores (mean, 63.1% versus 83.5%; P < .001; Hedge g effect size = 0.93). Of the 494 students who completed the Pathology-Teaches questions on the end-of-rotation evaluation, 251 provided specific feedback, with 38.6% (97 of 251) rating the activity as "extremely valuable" or "very valuable," and 41.4% (104 of 251) as "some/moderate value." Qualitative feedback included 17 positive comments with 6 requests to scale up or include more cases, 16 constructive comments for improvement mainly regarding the technical aspects, and 5 negative comments. CONCLUSIONS.: Pathology-Teaches effectively teaches stewardship concepts, and most students perceived value in this educational intervention.
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Estágio Clínico , Educação de Graduação em Medicina , Patologia/educação , Estudantes de Medicina , Serviços de Laboratório Clínico/economia , Redução de Custos , Análise Custo-Benefício , Currículo , Feedback Formativo , Custos de Cuidados de Saúde , Humanos , Patologia/economia , Projetos Piloto , Avaliação de Programas e Projetos de SaúdeRESUMO
OBJECTIVES: Promotion of high-quality care at a lower cost requires educational initiatives across the continuum of medical education. A needs assessment was performed to inform the design of an educational tool with the goal of teaching laboratory stewardship to medical students. METHODS: The needs assessment consisted of semistructured interviews with core clerkship directors and residency program directors at our institution, a national survey to the Undergraduate Medical Educators Section (UMEDS) of the Association of Pathology Chairs, and a review of existing online resources that teach high-value care. RESULTS: Two major themes emerged regarding opportunities to enhance laboratory stewardship education: appropriate ordering (knowledge of test indications, pretest/posttest probability, appropriateness criteria, recognition of unnecessary testing) and correct interpretation (understanding test specifications, factors that affect the test result, recognizing inaccurate results). CONCLUSIONS: The online educational tool will focus on the curricular needs identified, using a multidisciplinary approach for development and implementation.
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Estágio Clínico , Currículo , Educação a Distância , Educação de Graduação em Medicina , Laboratórios , Humanos , Internato e Residência , Diretores Médicos , Estudantes de MedicinaRESUMO
Emotional intelligence (EI) is the ability to recognize, understand, and manage emotions in yourself and in others. EI has long been recognized as a critical component for individual and organizational success within the business realm, and there is emerging evidence that enhancing EI is equally important in the medical setting. EI can improve interpersonal communications, enable constructive conflict resolution, and promote a culture of professionalism. As healthcare becomes increasingly team-based, proficiency in EI will be required to build consensus among multidisciplinary stakeholders, and effect change in attitudes and behaviors that result in improved patient safety and clinical outcomes. Based on the existing literature and the authors' experiences, these 12 tips provide practical suggestions on how to introduce EI into a medical curriculum. These tips have broad applicability, and can be implemented in courses on topics such as professionalism, leadership development, empathy, patient safety, or wellness.
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Educação Médica/organização & administração , Inteligência Emocional , Atitude do Pessoal de Saúde , Feedback Formativo , Processos Grupais , Humanos , Equipe de Assistência ao Paciente/organização & administração , Aprendizagem Baseada em Problemas/organização & administração , Autoavaliação (Psicologia) , Ensino/organização & administraçãoRESUMO
Primary mediastinal large B-cell lymphoma (PMBL) is a mature large B-cell lymphoma of putative thymic B-cell origin involving the mediastinum with younger age distribution and better prognosis than diffuse large B-cell lymphoma (DLBCL), not otherwise specified. Recently, based on gene expression profile analysis and morphologic findings, cases of PMBL without mediastinal involvement have been reported. In this study, we analyzed 3 cases of nodal DLBCL with morphologic features of PMBL presenting in submandibular or supraclavicular lymph nodes, in middle-aged to elderly patients, 2 of them without clinical or radiologic evidence of mediastinal involvement. The 3 patients presented with stage I/II disease and had excellent response to R-CHOP/R-EPOCH therapy. The 3 cases showed MAL expression and were positive for CD23 and/or CD30. All 3 cases expressed cyclin D1 with copy number gains of CCND1 gene but without rearrangement. There was no rearrangement of CIITA or PDL1/PDL2. Reverse transcriptase-multiplex ligation-dependent probe amplification, a mRNA-based gene expression profile analysis revealed high probability of PMBL (87.6%, 98.7%, and 99%) in these 3 cases. Targeted next-generation sequencing analysis showed SOCS1 mutations in the 3 cases, and TNFAIP3 and XPO1 mutations in one, further supporting the diagnosis of PMBL. In conclusion, we report 3 cases of nodal PMBL, 2 of them without mediastinal mass, and expression of cyclin D1 due to copy number gains of CCND1 gene, a diagnostic pitfall with mantle cell lymphoma and DLBCL, not otherwise specified.
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Ciclina D1/genética , Linfoma de Células B/diagnóstico , Linfoma de Células B/genética , Linfoma de Células B/patologia , Idoso , Idoso de 80 Anos ou mais , Variações do Número de Cópias de DNA , Diagnóstico Diferencial , Feminino , Humanos , Linfonodos/patologia , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma de Célula do Manto/diagnóstico , Masculino , Pessoa de Meia-IdadeRESUMO
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
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BACKGROUND: CD49d is emerging as a powerful adverse prognostic marker in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). However, flow cytometric testing for CD49d has not yet been widely adopted in the United States, in part due to the lack of establishment of its performance characteristics in the clinical setting, especially in comparison with the more common CLL/SLL prognostic markers CD38 and ZAP-70. METHODS: CD49d expression levels in 124 CLL/SLL cases were assessed among peripheral blood (PB), bone marrow (BM), and lymph node (LN) specimens and correlated with available CD38 and ZAP-70 expression and cytogenetic findings. For 10 PB/BM specimens, the stability of CD49d, CD38, and ZAP-70 expression was assessed at <24 hours, 48 hours, 72 hours, and 96 hours. RESULTS: 39% (28 of 71) PB, 56% (18 of 32) BM, and 71% (15 of 21) LN involved by CLL/SLL were CD49d+, using a ≥30% threshold. The mean for the CD49d+ cases was 2.8 standard deviations (SD) above the cutoff for positivity, compared with 1.7 SD for CD38 and 1.1 SD for ZAP-70. CD49d demonstrated the lowest mean SD (0.91) and coefficient of variation (CV) (8.0%) compared with CD38 (SD = 2.1, CV = 10.4%) and ZAP-70 (SD = 9.8, CV = 40.5%) in stability studies over a 96-hours time period. CD49d+ CLL/SLL correlated with trisomy 12 (P = 0.025) and lack of isolated deletion (13q) (P = 0.005). CD38+ CLL/SLL correlated with deletion (11q) (P = 0.025). ZAP-70 did not correlate with any underlying cytogenetic abnormality. CONCLUSIONS: CD49d is a robust adverse prognostic marker in CLL/SLL with superior performance characteristics. © 2016 International Clinical Cytometry Society.
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Integrina alfa4/metabolismo , Leucemia Linfocítica Crônica de Células B/diagnóstico , Leucemia Linfocítica Crônica de Células B/metabolismo , ADP-Ribosil Ciclase 1/metabolismo , Biomarcadores Tumorais/metabolismo , Medula Óssea/metabolismo , Aberrações Cromossômicas , Citometria de Fluxo/métodos , Humanos , Prognóstico , Proteína-Tirosina Quinase ZAP-70/metabolismoRESUMO
Coagulation factor XIII subunit A (FXIIIa) intracellular expression has been described in platelets, megakaryocytes, monocytic cells, and leukemic blasts. Flow cytometric-based studies have suggested prognostic implications of FXIIIa expression, especially within the acute promyelocytic leukemia (APL) subgroup of acute myeloid leukemia (AML); however, its prognostic correlate by immunohistochemistry (IHC) is unknown. The aims of this study were to (1) define the clinicopathologic features of FXIIIa IHC-positive AML and (2) compare APL with other AML subtypes. Eighty-seven bone marrow biopsies or clot/particle preparations from our institution were evaluated with FXIIIa IHC. The study cohort consisted of bone marrow evaluations of 36 consecutive pretherapy APL, 42 selected pretherapy non-APL AML, and 9 negative staging cases. FXIIIa IHC expression was correlated with clinical and pathologic features and overall survival (OS). Leukemic blast FXIIIa cytoplasmic positivity was noted in 56% (20/36) APL and 74% (31/42) non-APL AML (P=0.10). FXIIIa IHC expression was associated with inferior OS within the APL cohort (P=0.04). No OS differences were noted in comparing FXIIIa IHC expression in all AML (P=0.17), or FXIIIa IHC expression within favorable, intermediate or adverse cytogenetic groups (P=0.14, 0.22 and 0.87, respectively). FXIIIa IHC expression is observed among a broad spectrum of AML subtypes and is not characterized by specific pathologic features. However, within the APL subgroup, FXIIIa IHC expression is associated with an inferior outcome and may be useful for additional prognostic risk stratification.
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Fator XIII/metabolismo , Leucemia Promielocítica Aguda , Medula Óssea/patologia , Citometria de Fluxo/métodos , Humanos , Imuno-Histoquímica/métodos , Leucemia Promielocítica Aguda/patologia , Avaliação de Resultados em Cuidados de Saúde , PrognósticoRESUMO
AIMS: Elimination of non-value added testing without compromising high-quality clinical care is an important mandate for laboratories in a value-based reimbursement system. The goal of this study was to determine the optimal combination of flow cytometric markers for a screening approach that balances efficiency and accuracy. METHODS: An audit over 9â months of flow cytometric testing was performed, including rereview of all dot plots from positive cases. RESULTS: Of the 807 cases in which leukaemia/lymphoma testing was performed, 23 were non-diagnostic and 189 represented bronchoalveolar lavage specimens. Of the remaining 595 cases, 137 (23%) were positive for an abnormal haematolymphoid population. Review of the positive cases identified minimum requirements for a screening tube as well as analysis strategies to overcome the diagnostic pitfalls noted. It is estimated that 38% fewer antibodies would be used in a screening approach, representing an opportunity for significant cost savings. CONCLUSIONS: We provide a framework for developing an evidence-based screening combination for cost-effective characterisation of haematolymphoid malignancies, promoting adoption of 'just-in-time' testing systems that tailor the evaluation to the diagnostic need.
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Biomarcadores Tumorais/análise , Medicina Baseada em Evidências , Citometria de Fluxo , Imunofenotipagem/métodos , Leucemia/metabolismo , Linfoma/metabolismo , Redução de Custos , Análise Custo-Benefício , Diagnóstico Diferencial , Erros de Diagnóstico , Citometria de Fluxo/economia , Citometria de Fluxo/normas , Custos de Cuidados de Saúde , Humanos , Imunofenotipagem/economia , Imunofenotipagem/normas , Leucemia/patologia , Linfoma/patologia , Auditoria Médica , Valor Preditivo dos Testes , Indicadores de Qualidade em Assistência à Saúde , Reprodutibilidade dos Testes , Fluxo de TrabalhoAssuntos
Mastócitos/metabolismo , Mastócitos/patologia , Transtornos Mieloproliferativos/genética , Transtornos Mieloproliferativos/patologia , Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/genética , Adulto , Medula Óssea/patologia , Contagem de Células , Humanos , Imunofenotipagem , Hibridização in Situ Fluorescente , Masculino , Transtornos Mieloproliferativos/diagnóstico , Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo , Translocação GenéticaRESUMO
Pediatric-type nodal follicular lymphoma (PTNFL) is a variant of follicular lymphoma (FL) characterized by limited-stage presentation and invariably benign behavior despite often high-grade histological appearance. It is important to distinguish PTNFL from typical FL in order to avoid unnecessary treatment; however, this distinction relies solely on clinical and pathological criteria, which may be variably applied. To define the genetic landscape of PTNFL, we performed copy number analysis and exome and/or targeted sequencing of 26 PTNFLs (16 pediatric and 10 adult). The most commonly mutated gene in PTNFL was MAP2K1, encoding MEK1, with a mutation frequency of 43%. All MAP2K1 mutations were activating missense mutations localized to exons 2 and 3, which encode negative regulatory and catalytic domains, respectively. Missense mutations in MAPK1 (2/22) and RRAS (1/22) were identified in cases that lacked MAP2K1 mutations. The second most commonly mutated gene in PTNFL was TNFRSF14, with a mutation frequency of 29%, similar to that seen in limited-stage typical FL (P = .35). PTNFL was otherwise genomically bland and specifically lacked recurrent mutations in epigenetic modifiers (eg, CREBBP, KMT2D). Copy number aberrations affected a mean of only 0.5% of PTNFL genomes, compared with 10% of limited-stage typical FL genomes (P < .02). Importantly, the mutational profiles of PTNFLs in children and adults were highly similar. Together, these findings define PTNFL as a biologically and clinically distinct indolent lymphoma of children and adults characterized by a high prevalence of MAPK pathway mutations and a near absence of mutations in epigenetic modifiers.
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Linfoma Folicular/enzimologia , Linfoma Folicular/genética , Sistema de Sinalização das MAP Quinases/genética , Mutação/genética , Adolescente , Fatores Etários , Forma Celular , Criança , Pré-Escolar , Variações do Número de Cópias de DNA/genética , Epigênese Genética , Feminino , Humanos , Imunofenotipagem , Lactente , Linfoma Folicular/patologia , MasculinoRESUMO
CD4+ small/medium pleomorphic T-cell lymphoma is a relatively rare subtype of cutaneous lymphoproliferative disorder with an indolent clinical behavior. The place of this condition among lymphomas is debatable. The authors describe a rare case of the direct association of CD4 small/medium pleomorphic T-cell lymphoma-like solitary nodule with Borrelia burgdorferi infection in a 5-year-old boy, discuss the reactive nature of this condition, and emphasize the importance of clinicopathological correlation.
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Linfócitos T CD4-Positivos/imunologia , Eritema Migrans Crônico/imunologia , Eritema Migrans Crônico/patologia , Linfoma Cutâneo de Células T/patologia , Neoplasias Cutâneas/patologia , Pré-Escolar , Diagnóstico Diferencial , Humanos , Linfoma Cutâneo de Células T/imunologia , Masculino , Neoplasias Cutâneas/imunologiaRESUMO
"Double" or "triple" hit lymphomas (D/THL) with recurrent translocations involving MYC/8q24 and BCL2/18q21 and/or BCL6/3q27 are characterized by a poor prognosis, but their identification is hampered by the clinicopathologic overlap with other disease categories. Cases with circulating blastic-appearing cells may initially cause concern for lymphoblastic leukemia a diagnostic dilemma, which has not been well studied. There is only limited literature regarding the flow cytometric (FC) D/THL phenotype and its clinical correlates. The FC features of 20 D/THL (11 BCL2(+)/MYC(+), 5 BCL6(+)/MYC(+), 4 BCL2(+)/BCL6(+)/MYC(+)) were evaluated, compared to 20 B-lymphoblastic leukemias (B-LBL), and correlated with overall survival. Most (89%, 17/19) D/THL were CD10(+), 47% (9/19) lacked surface light chain, and a significant subset underexpressed CD45 (47%, 9/19), CD20 (42% 8/19), and/or CD19 (39%, 7/18), which did not vary by genetic subgroup. Compared to B-LBL, D/THL less frequently underexpressed CD45 (p = 0.0001) and CD20 (p = 0.0004). Lower levels of BCL2 expression were noted in the BCL6(+)/MYC(+) and BCL2(+)/BCL6(+)/MYC(+) subgroups versus BCL2(+)/MYC(+) cases (p = 0.0014). Of the flow cytometric parameters assessed, dim CD45 expression correlated with inferior survival (p = 0.01). Although there is some overlap with B-LBL, D/THL demonstrates a characteristic immunophenotype which may have prognostic significance and warrants further investigation.
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Citometria de Fluxo , Imunofenotipagem , Leucemia-Linfoma Linfoblástico de Células Precursoras/genética , Translocação Genética/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Antígenos CD19/imunologia , Antígenos CD20/imunologia , Feminino , Regulação Neoplásica da Expressão Gênica/imunologia , Humanos , Antígenos Comuns de Leucócito/imunologia , Masculino , Pessoa de Meia-Idade , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/imunologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteínas Proto-Oncogênicas c-bcl-2/imunologia , Proteínas Proto-Oncogênicas c-bcl-6/genética , Proteínas Proto-Oncogênicas c-bcl-6/imunologia , Proteínas Proto-Oncogênicas c-myc/genética , Proteínas Proto-Oncogênicas c-myc/imunologiaAssuntos
Leucemia Mieloide Aguda/diagnóstico , Leucemia Plasmocitária/diagnóstico , Plasmócitos/patologia , Antígenos CD/análise , Medula Óssea/metabolismo , Medula Óssea/patologia , Deleção de Genes , Humanos , Imunofenotipagem , Cariótipo , Leucemia Plasmocitária/complicações , Leucemia Plasmocitária/genética , Leucemia Plasmocitária/patologia , Masculino , Pessoa de Meia-Idade , Plasmócitos/metabolismo , Proteína Supressora de Tumor p53/genéticaAssuntos
Biomarcadores Tumorais/genética , Subunidade alfa de Receptor de Interleucina-3/genética , Leucemia-Linfoma Linfoblástico de Células T Precursoras/diagnóstico , Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética , Linfócitos T/imunologia , Adulto , Idoso , Antígenos CD1/genética , Antígenos CD1/imunologia , Biomarcadores Tumorais/imunologia , Antígenos CD5/genética , Antígenos CD5/imunologia , Antígenos CD8/genética , Antígenos CD8/imunologia , Criança , Pré-Escolar , Feminino , Expressão Gênica , Humanos , Imuno-Histoquímica , Imunofenotipagem , Subunidade alfa de Receptor de Interleucina-3/imunologia , Masculino , Pessoa de Meia-Idade , Leucemia-Linfoma Linfoblástico de Células T Precursoras/imunologia , Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia , Prognóstico , Linfócitos T/patologia , Adulto JovemRESUMO
Lyme disease can affect the central nervous system causing a B-cell-predominant lymphocytic pleocytosis. Since most reactions to infection in the cerebrospinal fluid (CSF) are typically T-cell predominant, a B-cell-predominant lymphocytosis raises concern for lymphoma. We present 3 Lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their CSF specimens. Three male patients who presented with central nervous system manifestations were diagnosed with Lyme disease. The clinical presentation, laboratory tests, CSF cytological examination and flow-cytometric studies were described for each case. CSF cytology showed lymphocytic pleocytosis with increased plasmacytoid cells and/or plasma cells. Flow cytometry showed the presence of polytypic B lymphocytes with evidence of plasmacytic differentiation in 2 cases. In all cases, Lyme disease was confirmed by the Lyme screening test and Western blotting. In such cases of Lyme neuroborreliosis, flow cytometry of CSF samples employing plasmacytic markers and cytoplasmic light-chain analysis is diagnostically helpful to exclude lymphoma.
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Neuroborreliose de Lyme/líquido cefalorraquidiano , Neuroborreliose de Lyme/patologia , Adulto , Citometria de Fluxo/métodos , Humanos , Neuroborreliose de Lyme/diagnóstico , Masculino , Pessoa de Meia-IdadeRESUMO
Lymphoplasmacytic infiltrates in the breast, a modified skin appendage, include lymphocytic lobulitis, other nonspecific benign proliferations, and mucosa-associated lymphoid tissue (MALT)-type lymphoma. Distinguishing these entities, all of which may be B-cell rich and may have associated sclerosis, can be difficult. In addition, the proportion that represents IgG4-related disease is unknown, and the similarity of MALT lymphomas to primary cutaneous marginal zone lymphoma is uncertain. To address these questions, the clinical, histologic, and immunohistochemical features of 50 benign and malignant breast lymphoplasmacytic infiltrates (10 lymphocytic lobulitis, 1 granulomatous, 19 not otherwise specified, 20 MALT lymphomas) were evaluated. Compared with the MALT lymphomas, benign cases had a less dense infiltrate (P < .001), fewer but more histologically apparent germinal centers (P < .001), and more marked fibrosis (P < .0001). Greater than 60% B cells were present in 23% (7/30) benign cases versus 75% (15/20) MALT lymphomas (P = .0003). Plasma cells were predominantly IgG+ in 83% (24/29) benign cases and predominantly IgM+ in 73% (14/19) MALT lymphomas (P < .0001). None of the benign cases had greater than 50 IgG4+ plasma cells/high-power field, and only 1 lymphocytic lobulitis case had an IgG4/IgG ratio exceeding 40% and no clinical evidence for extramammary IgG4-related disease. Although there may be some overlapping features, routine histopathology together with limited immunohistochemical stains can distinguish benign from neoplastic lymphoplasmacytic infiltrates in the breast. Despite frequent sclerosis, the breast is not a common site of unrecognized IgG4-related sclerosing disease. Although there are similarities, breast MALT lymphomas can be separated from cutaneous marginal zone lymphoma.
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Neoplasias da Mama/diagnóstico , Linfoma de Zona Marginal Tipo Células B/diagnóstico , Adulto , Doenças Mamárias/diagnóstico , Doenças Mamárias/imunologia , Neoplasias da Mama/imunologia , Diagnóstico Diferencial , Feminino , Humanos , Imunoglobulina G/análise , Imuno-Histoquímica , Linfoma de Zona Marginal Tipo Células B/imunologia , GravidezRESUMO
Virtual microscopy has been adopted by many medical schools but often without addressing the need for students to understand how to integrate slide observations with other diagnostic information. The goal of this study was to develop an innovative tool for teaching pathology to medical students that presents a variety of virtual materials necessary for a complete pathology evaluation. The Virtual Pathology Instructor (V-PIN) is patient simulation software (vpSim) created and supported by the University of Pittsburgh School of Medicine, Laboratory for Educational Technology, and allows students to assume the role of a diagnostic pathologist. V-PIN utility was demonstrated by educationally significant improvement between pretest and posttest scores for 2 cases (mean, 3.8 versus 4.2; P = .0007; 1.9 versus 3.0; P = .0001). A third case did not perform as well (mean, 2.5 versus 2.3; P = .12) but detailed evaluation of the performance of the case identified possible improvements. Maximum posttest performance was seen following both the traditional workshop and the V-PIN case as compared to the case alone (posttest 4.2 versus 3.0; P < .0001). No significant difference was identified in student progress through V-PIN cases taken before or after the related traditional workshop, as demonstrated by total time on task, number of steps to complete, total score, number of incorrect answers, and number of requests for V-PIN help. Patient simulation software is an effective tool for teaching pathology to medical students and can provide individual instruction and immediate feedback as well as identify opportunities to refine and enhance the educational experience.