A Scoping Review of Otologic Manifestations of Hematologic Malignancies.

OBJECTIVE: To examine the otologic and neurotologic symptoms, physical examination findings, and imaging features secondary to hematologic malignancies. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, databases, including PubMed, Scopus, and CINAHL, were searched for articles including patients with otologic manifestations of leukemia, lymphoma and multiple myeloma. Data collected included patient and study demographics, specific hematologic malignancy, timing and classification of otologic symptoms, physical examination findings, imaging features and methods of diagnosis. Pooled descriptive analysis was performed. RESULTS: Two hundred seventy-two articles, of which 255 (93.8%) were case reports and 17 (6.2%) were case series, reporting on 553 patients were identified. Otologic manifestations were reported on 307 patients with leukemia, 204 patients with lymphoma and 42 patients with multiple myeloma. Hearing loss and unilateral facial palsy were the most common presenting symptoms for 111 reported subjects with leukemia (n = 46, 41.4%; n = 43, 38.7%) and 90 with lymphoma (n = 38, 42.2%; n = 39, 43.3%). Hearing loss and otalgia were the most common presenting symptoms for 21 subjects with multiple myeloma (n = 10, 47.6%; n = 6, 28.6%). Hearing loss and unilateral facial palsy were the most common otologic symptoms indicative of relapse in subjects with leukemia (n = 14, 43.8%) and lymphoma (n = 5, 50%). CONCLUSION: Hearing loss, facial palsy, and otalgia might be the first indication of a new diagnosis or relapse of leukemia, lymphoma, or multiple myeloma. Clinicians should have a heightened level of suspicion of malignant etiologies of otologic symptoms in patients with current or medical histories of these malignancies.

Video Analysis of Otologic Instrument Movement During Resident Mastoidectomies.

OBJECTIVE: To measure surgical instrument movement during resident mastoidectomies and identify metrics that correlate with experience. STUDY DESIGN: Retrospective case series. SETTING: Tertiary care center. SUBJECTS: Ten postgraduate year (PGY) 2, 6 PGY3, 7 PGY4, and 19 PGY5 recordings of mastoidectomy performed by otolaryngology residents. INTERVENTIONS: One-minute intraoperative recordings of mastoidectomies performed during cochlear implantation were collected. Drill and suction-irrigator motion were analyzed with sports motion tracking software. MAIN OUTCOME MEASURES: Mean instrument speed, angle, and angular velocity were calculated. Mann-Whitney U tests compared mean instrument metrics between PGY levels. Change in drill speed for seven residents between their PGY2 to PGY5 years was individually analyzed. RESULTS: Mean drill speed was significantly greater for PGY5 residents compared with PGY2s (2.9 versus 1.8 cm/s, p = 0.001). Compared with PGY2 residents, suction speed was greater as a PGY5 (1.2 versus 0.9 cm/s; p = 0.201) and significantly greater as a PGY4 (1.5 versus 0.9 cm/s, p = 0.039). Of the seven residents individually analyzed, group mean drill speed increased by 0.4 cm/s, yearly. CONCLUSIONS: Drill and suction-irrigator movement during the second minute of drilling of a cortical mastoidectomy seems to increase with resident level. Objective video analysis is a potential adjunct for differentiating novices from more experienced surgeons and monitoring surgical skills progress.

Using Intraoperative Recordings to Evaluate Surgical Technique and Performance in Mastoidectomy.

Importance: Otolaryngology residency programs currently lack rigorous methods for assessing surgical skill and often rely on biased tools of evaluation. Objectives: To evaluate which techniques used in mastoidectomy can serve as indicators of surgeon level (defined as the level of training) and whether these determinations of technique can be made based solely on the movement of the drill head or suction. Design, Setting, and Participants: In this prospective, observational study conducted from January 1, 2015, to December 31, 2019, at a single tertiary care institution, 3 independent observers made blinded evaluations on 24 intraoperative recordings of surgeons (6 junior residents, 4 senior residents, and 2 attending surgeons) performing mastoidectomies. Main Outcomes and Measures: Observers assessed drill stroke count, drilling efficiency, stroke pattern, use of suction and irrigation, and estimated surgeon level. Assessments were made on both original videos and animated videos that show only the path of the burr head or suction as dots against a white background. Results: Among the 24 recorded mastoidectomies performed by the 12 study surgeons, intraclass correlation was excellent for original video assessment of drill stroke count (0.98 [95% CI, 0.97-1.00]), use of suction (0.75 [95% CI, 0.52-0.89]), use of irrigation (0.83 [95% CI, 0.66-0.92]), and estimated surgeon level (0.82 [95% CI, 0.64-0.92]) and fair for drilling efficiency (0.54 [95% CI, 0.09-0.79]) and stroke pattern (0.49 [95% CI, -0.02 to 0.76]). Intraclass correlation was excellent for animated video assessment of drill stroke count per unit time (0.98 [95% CI, 0.96-0.99]) and drilling efficiency (0.80 [95% CI, 0.60-0.91]), good for stroke pattern (0.68 [95% CI, 0.38-0.85]) and estimated surgeon level (based on path of drill) (0.69 [95% CI, 0.38-0.85]), and fair for use of suction (0.58 [95% CI, 0.16-0.80]) and estimated surgeon level (based on path of suction) (0.58 [95% CI, 0.17-0.80]). On evaluation of original videos, junior residents had lower drill stroke count compared with senior residents and attending surgeons (6.0 [interquartile range (IQR), 3.0-8.0] vs 9.5 [IQR, 5.0-13.0] vs 10.5 [IQR, 5.0-17.8]; η2 = 0.14 [95% CI, 0.01-0.28]). On evaluation of animated videos, junior residents also had lower drill stroke count compared with senior residents and attending surgeons (6.0 [IQR, 4.0-9.0] vs 10.5 [IQR, 10.0-13.8] vs 10.5 [IQR, 4.3-21.0]; η2 = 0.19 [95% CI, 0.04-0.33]). Compared with junior and senior residents, attending surgeons had higher median ratings of drilling efficiency (original videos: junior residents, 4.0 [IQR, 3.0-4.0]; senior residents, 4.0 [IQR, 3.0-4.8]; attending surgeons, 5.0 [IQR, 4.3-5.0]; η2 = 0.23 [95% CI, 0.06-0.37]; animated videos: junior residents, 4.0 [IQR, 3.0-4.0]; senior residents, 3.0 [IQR, 2.0-4.0]; attending surgeons, 5.0 [IQR, 4.0-5.0]; η2 = 0.25 [95% CI, 0.08-0.39]) and stroke pattern (original videos: junior residents, 4.0 [IQR, 3.0-4.0]; senior residents, 4.0 [IQR, 3.0-4.8]; attending surgeons, 5.0 [IQR, 5.0-5.0]; η2 = 0.17 [95% CI, 0.03-0.31]; animated videos: junior residents, 4.0 [IQR, 3.0-4.0]; senior residents, 4.0 [IQR, 2.0-4.0]; attending surgeons, 5.0 [IQR, 5.0-5.0]; η2 = 0.15 [95% CI, 0.02-0.29]). Conclusions and Relevance: This study suggests that observation of intraoperative mastoidectomy recordings is a feasible method of evaluating surgeon level. Reasonable indicators of surgeon level include the drill stroke count, drilling efficiency, stroke pattern, and use of the suction irrigator. Observing the path of the drill alone is sufficient to appreciate differences in drilling technique but not sufficient to accurately determine surgeon level. Intraoperative recordings can serve as a useful addition to resident education and evaluation.

Different types of associative encoding evoke differential processing in both younger and older adults: Evidence from univariate and multivariate analyses.

Age-related deficits in associative processing are well-documented (e.g., Naveh-Benjamin, 2000) and have been assumed to be the result of a general deficit that affects all types of binding. However, recent behavioral research has indicated that the visual configuration of the information that is presented to older adults influences the degree to which this binding deficit is exhibited by older adults (Overman, Dennis et al, 2019; Overman, Dennis, et al., 2018). The purpose of the present study was to further clarify the neural underpinnings of the associative deficit in aging and to examine whether functional activity at encoding differs with respect to the visual configuration and the type of associative being encoded. Using both univariate and multi-voxel pattern analysis, we found differences in both the magnitude of activation and pattern of neural responses associated with the type of association encoded (item-item and item-context). Specifically, our results suggest that, when controlling for stimuli composition, patterns of activation in sensory and frontal regions within the associative encoding network are able to distinguish between different types of associations. With respect to the MTL, multivariate results suggest that only patterns of activation in the PrC in older, but not younger adults, can distinguish between associations types. These findings extend prior work regarding the neural basis of associative memory in young and older adults, and extends the predictions of the binding of item and context model (BIC; Diana, Yonelinas, Ranganath, 2007) to older adults.