[Weakly mineralized nitrogen thermal waters of Russia]. / Azotnye slabomineralizovannye termal'nye mineral'nye vody Rossii.

Russia has almost all hydrochemical types of underground mineral waters; however, unlike the well-known and popular resorts in the world, they are used very limitedly. In addition to their high medicinal value, mineral waters, when properly marketed, is a natural product that is comparable, and, in many cases, superior in price to that of similar volumes of high-octane gasoline. In addition to the characteristics of the chemical and gas composition, some underground mineral waters in their native state have an elevated temperature and are thermal and hyperthermal. Low-mineralized nitrogen thermae are one of the large groups of mineral waters; they are common in the areas of young tectonic faults in the earth's crust, which frame the mountainous areas. The deposits of thermae within the blocky and folded-blocky structures are fractured water-pressure systems; the thermal waters in the sedimentary and volcanic-sedimentary rocks saturate the reservoir or fissure-interstitial aquifers and are typical artesian basins. The successful development of health resort business in Russia should be, first of all, based on the extensive use of natural therapeutic factors. As clearly confirmed by the experience with spa treatment in both Russia and world practice, accumulated data from researches, thermal mineral waters determine the possibility of creating large spa centers that provide high economic efficiency.

[Use of fendivia transdermal therapeutic system in Russian patients with malignant neoplasms during palliative care: pharmacoeconomic aspects].

AIM: To make a comparative clinical and economic assessment of a transdermal therapeutic system (TTS) for fendivia and traditional opioid analgesics in patients with malignant neoplasms (MN) during palliative care. MATERIALS AND METHODS: Pharmacoeconomic analysis of opioid analgesics used in patients with MN during analgesic therapy was made using the cost-effectiveness analysis in the framework of a budget impact analysis (BIA). RESULTS: The assessment of the medical cost structure in the fendivia and morphine groups (100 patients in each group), which was made in the framework of BIA, demonstrated that the cost of pharmacotherapy in the fendivia group was comparable with that of an ambulance call for additional analgesia and correction of the side effects of performed therapy (615,804.00 and 645,337.60 rbl. monthly, respectively). At the same time, in the morphine group the cost of an ambulance call was more than 20 times that of pharmacotherapy (2,117,514.00 and 93,120.00 rbl. monthly, respectively). Thus, the total savings from applying the fendivia TTS in the group of 100 patients ranged up to 949,492.40 rbl. monthly. CONCLUSION: The application of the fendivia TTS is clinically and pharmacoeconomically valid and leads to a considerable reduction in public health care costs.