RESUMO
OBJECTIVE: We aim to assess the effect of low-pressure pneumoperitoneum on post operative pain and ten of the known inflammatory markers. BACKGROUND: The standard of care pneumoperitoneum set pressure in laparoscopic cholecystectomy is set to 12-14 mmHg, but many societies advocate to operate at the lowest pressure allowing adequate exposure of the operative field. Many trials have described the benefits of operating at a low-pressure pneumoperitoneum in terms of lower post operative pain, and better hemodynamic stability. But only few describe the effects on inflammatory markers and cytokines. METHODS: A prospective, double-blinded, randomised, controlled clinical trial, including patients who underwent elective laparoscopic cholecystectomy. Patients randomised into low-pressure (8-10 mmHg) vs. standard-pressure (12-14 mmHg) with an allocation ratio of 1:1. Perioperative variables were collected and analysed. RESULTS: one hundred patients were allocated, 50 patients in each study arm. Low-pressure patients reported lower median pain score 6-hour post operatively (5 vs. 6, p-value = 0.021) in comparison with standard-pressure group. Eight out of 10 inflammatory markers demonstrated better results in low-pressure group in comparison with standard-pressure, but the effect was not statistically significant. Total operative time and surgery difficulty was not significantly different between the two groups even in the hands of inexperienced surgeons. CONCLUSION: low-pressure laparoscopic cholecystectomy is associated with less post operative pain and lower rise of inflammatory markers. It is feasible with comparable complications to the standard of care. Registered on ClinicalTrials.gov (NCT05530564/ September 7th, 2022).
Assuntos
Colecistectomia Laparoscópica , Pneumoperitônio , Humanos , Colecistectomia Laparoscópica/métodos , Estudos Prospectivos , Pneumoperitônio/complicações , Pneumoperitônio Artificial/efeitos adversos , Pneumoperitônio Artificial/métodos , Dor Pós-Operatória/etiologia , Inflamação/complicaçõesRESUMO
Despite being relatively uncommon, abdominal wall hematomas can occur due to blunt trauma, post-percutaneous procedures, anticoagulation, and even spontaneous bleeding. It can present with varying symptoms from acute abdominal pain to life-threatening bleeding causing hypovolemia and shock. With the coronavirus disease 2019 (COVID-19) pandemic, affected patients developed coagulopathy putting patients at risk of venous thromboembolism or excessive bleeding. Herein, we report a case of spontaneous multiple abdominal wall hematomas in a patient after a COVID-19 infection, which was managed conservatively.