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This study aimed to investigate the ability of aqueous extract of Lepidium sativum seeds (LSE) to improve the wound healing process in rat models. The gelatin, extracted from the skin of smooth-hound shark using citric acid, was used as a support material for ointment. Animals were divided into four groups of six rats each: an untreated control group, a control group treated with Moist Exposed Burn Ointment (MEBO), a treated group with gelatin gel, and a treated group with gelatin gel fortified with 20 mg/mL LSE. Phenolics profile analysis showed that the major compounds in LSE were catechin (125 µg/g) and quinic acid (105 µg/g). In vitro antioxidant tests showed that LSE has interesting activities to scavenge ABTSâ¢+ radicals (IC50 = 0.22 mg/mL) and inhibit the oxidation of linoleic acid. A significant decline in the antioxidant enzymes activities and an increase in the level of thiobarbituric acid reactive substances (TBARS) and inflammatory markers was observed within the injured tissues of the untreated rats compared to rats treated with MEBO. Interestingly, when the wounded tissue was treated with gelatin gel a remarkable reversal of this trend occurred. Further, by enrichment of gelatin gel with LSE, the levels of CAT, GPx and SOD activities significantly increased by 35, 126, and 212 %, respectively, whereas the TBARS level was reduced by 31 %. These results were consistent with the wound contraction percentage and histological analysis, which suggest the potential effect of LSE-enriched gelatin gels to regenerate damaged tissues.
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The goal of the current study was to create and assess the effectiveness of a hand-pulled ergonomically designed flame weeder. The developed weeder was tested in the field at three operating pressures (20, 30 and 40 Psi) and forward speeds (1.00, 1.25 and 1.50 km/h) to study their effects on plant damage, survival rates, weight preservation rates, weed management effectiveness, soil temperatures, and gas and energy consumption. Thereafter, at optimized values of forward speed and operating pressure, a comparative assessment of flame weeding with traditional methods (mechanical and manual weeding) was done in terms of weed control effectiveness, operational time, energy consumption, and cost of operation. Results showed that the optimal performance of the designed flame weeder was achieved when operated at a speed of 1 km/h and an operating pressure of 40 psi. The survival rate, weight preservation rate, weed control efficiency, change in soil temperature, recovery rate, plant damage, gas consumption, and energy consumption were observed to be 27.3 %, 32.5 %, 91.1 %, 40.74 °C, 8.5 %, 2.2 %, 4.05 kg/h, and 2500.24 MJ/ha, respectively, at optimized values of forward speed (1.00 km/h) and operating pressure (40 Psi). The actual field capacity, field efficiency and operating cost of the flame weeder were 0.0755 ha/h, 94.94 %, and 3620.81 â¹/ha, respectively. Hand weeding had the best level of weed control effectiveness, but it was a laborious, time-consuming process. When compared to manual weeding, flame weeding was 50.42 % cheaper and 94.82 % faster.
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Food packaging must guarantee the products' quality during the different operations including packing and maintenance throughout transportation and storage until to consumption. Thus, it should satisfy, both, food freshness and quality preservation and consumers health safety. Natural bio-sourced polymers have been explored as safe edible materials for several packaging applications, being interestingly carrier of bioactive substances, once added to improve films' properties. Gelatin and chitosan are among the most studied biomaterials for the preparation of edible packaging films due to their excellent characteristics including biodegradability, compatibility and film-forming property. These polymers could be used alone or in combination with other polymers to produce composite films with the desired physicochemical and mechanical properties. When incorporated with bioactive substances (natural extracts, polyphenolic compounds, essential oils), chitosan/gelatin-based films acquired various biological properties, including antioxidant and antimicrobial activities. The emerging bioactive composite films with excellent physical attributes represent excellent packaging alternative to preserve different types of foodstuffs (fruits, meat, fish, dairy products, ) and have shown great achievements. This chapter provides the main techniques used to prepare gelatin- and chitosan- based films, showing some examples of bioactive compounds incorporated into the films' matrix. Also, it illustrates the outstanding advantages given by these biomaterials for food preservation, when used as coating and wrapping agents.
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Materiais Biocompatíveis , Quitosana , Embalagem de Alimentos , Conservação de Alimentos , Gelatina , Gelatina/química , Quitosana/química , Embalagem de Alimentos/métodos , Materiais Biocompatíveis/química , Conservação de Alimentos/métodos , HumanosRESUMO
Ensuring the security of China's rice harvest is imperative for sustainable food production. The existing study addresses a critical need by employing a comprehensive approach that integrates multi-source data, including climate, remote sensing, soil properties and agricultural statistics from 2000 to 2017. The research evaluates six artificial intelligence (AI) models including machine learning (ML), deep learning (DL) models and their hybridization to predict rice production across China, particularly focusing on the main rice cultivation areas. These models were random forest (RF), extreme gradient boosting (XGB), conventional neural network (CNN) and long short-term memory (LSTM), and the hybridization of RF with XGB and CNN with LSTM based on eleven combinations (scenarios) of input variables. The main results identify that hybrid models have performed better than single models. As well, the best scenario was recorded in scenarios 8 (soil variables and sown area) and 11 (all variables) based on the RF-XGB by decreasing the root mean square error (RMSE) by 38% and 31% respectively. Further, in both scenarios, RF-XGB generated a high correlation coefficient (R2) of 0.97 in comparison with other developed models. Moreover, the soil properties contribute as the predominant factors influencing rice production, exerting an 87% and 53% impact in east and southeast China, respectively. Additionally, it observes a yearly increase of 0.16 °C and 0.19 °C in maximum and minimum temperatures (Tmax and Tmin), coupled with a 20 mm/year decrease in precipitation decline a 2.23% reduction in rice production as average during the study period in southeast China region. This research provides valuable insights into the dynamic interplay of environmental factors affecting China's rice production, informing strategic measures to enhance food security in the face of evolving climatic conditions.
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Aprendizado de Máquina , Oryza , Oryza/crescimento & desenvolvimento , China , Solo/química , Redes Neurais de Computação , Agricultura/métodos , ClimaRESUMO
Liquefaction is a devastating consequence of earthquakes that occurs in loose, saturated soil deposits, resulting in catastrophic ground failure. Accurate prediction of such geotechnical parameter is crucial for mitigating hazards, assessing risks, and advancing geotechnical engineering. This study introduces a novel predictive model that combines Extreme Learning Machine (ELM) with Dingo Optimization Algorithm (DOA) to estimate strain energy-based liquefaction resistance. The hybrid model (ELM-DOA) is compared with the classical ELM, Adaptive Neuro-Fuzzy Inference System with Fuzzy C-Means (ANFIS-FCM model), and Sub-clustering (ANFIS-Sub model). Also, two data pre-processing scenarios are employed, namely traditional linear and non-linear normalization. The results demonstrate that non-linear normalization significantly enhances the prediction performance of all models by approximately 25% compared to linear normalization. Furthermore, the ELM-DOA model achieves the most accurate predictions, exhibiting the lowest root mean square error (484.286 J/m3), mean absolute percentage error (24.900%), mean absolute error (404.416 J/m3), and the highest correlation of determination (0.935). Additionally, a Graphical User Interface (GUI) has been developed, specifically tailored for the ELM-DOA model, to assist engineers and researchers in maximizing the utilization of this predictive model. The GUI provides a user-friendly platform for easy input of data and accessing the model's predictions, enhancing its practical applicability. Overall, the results strongly support the proposed hybrid model with GUI serving as an effective tool for assessing soil liquefaction resistance in geotechnical engineering, aiding in predicting and mitigating liquefaction hazards.
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One fascinating concept for enhancing the durability and lifespan of concrete buildings involves the use of self-healing concrete. This study focuses on the effect of crystalline admixtures and coatings on various properties of self-healing concrete and provides a comparison with traditional concrete. Four different concrete mixtures were prepared to assess their effectiveness in bridging crack openings, their flexural and compressive strengths, and water absorption. Various testing methods, including destructive, semi-destructive, and non-destructive tests, were used in this research. The capacity of the mixes to repair themselves was assessed on the destroyed and semi-destroyed test specimens using crack-healing and microstructure testing. Additionally, all mixtures were also subjected to the slump cone test and air content test in order to investigate the characteristics of the concrete in its fresh state. The findings demonstrate that crystalline coating and admixture combinations have significant potential for healing concrete. The compressive and bending strengths of self-healing concrete mixtures were shown to be slightly higher compared to traditional concrete when the additive dose was increased. Self-healing concrete mixtures also exhibited much lower water absorption, a tightly packed and improved microstructure, and signs of healed gaps, all of which indicate greater durability.
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Polyp detection is a challenging task in the diagnosis of Colorectal Cancer (CRC), and it demands clinical expertise due to the diverse nature of polyps. The recent years have witnessed the development of automated polyp detection systems to assist the experts in early diagnosis, considerably reducing the time consumption and diagnostic errors. In automated CRC diagnosis, polyp segmentation is an important step which is carried out with deep learning segmentation models. Recently, Vision Transformers (ViT) are slowly replacing these models due to their ability to capture long range dependencies among image patches. However, the existing ViTs for polyp do not harness the inherent self-attention abilities and incorporate complex attention mechanisms. This paper presents Polyp-Vision Transformer (Polyp-ViT), a novel Transformer model based on the conventional Transformer architecture, which is enhanced with adaptive mechanisms for feature extraction and positional embedding. Polyp-ViT is tested on the Kvasir-seg and CVC-Clinic DB Datasets achieving segmentation accuracies of 0.9891 ± 0.01 and 0.9875 ± 0.71 respectively, outperforming state-of-the-art models. Polyp-ViT is a prospective tool for polyp segmentation which can be adapted to other medical image segmentation tasks as well due to its ability to generalize well.
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Pólipos , Humanos , Instituições de Assistência Ambulatorial , Erros de Diagnóstico , Fontes de Energia Elétrica , Colo , Processamento de Imagem Assistida por ComputadorRESUMO
Groundwater serves as a primary water source for various purposes. Therefore, aquifer pollution poses a critical threat to human health and the environment. Identifying the aquifer's highly vulnerable areas to pollution is necessary to implement appropriate remedial measures, thus ensuring groundwater sustainability. This paper aims to enhance groundwater vulnerability assessment (GWVA) to manage aquifer quality effectively. The study focuses on the El Orjane Aquifer in the Moulouya basin, Morocco, which is facing significant degradation due to olive mill wastewater. Groundwater vulnerability maps (GVMs) were generated using the DRASTIC, Pesticide DRASTIC, SINTACS, and SI methods. To assess the effectiveness of the proposed improvements, 24 piezometers were installed to measure nitrate concentrations, a common indicator of groundwater contamination. This study aimed to enhance GWVA by incorporating new layers, such as land use, and adjusting parameter rates based on a comprehensive sensitivity analysis. The results demonstrate a significant increase in Pearson correlation values (PCV) between the produced GVMs and measured nitrate concentrations. For instance, the PCV for the DRASTIC method improved from 0.42 to 0.75 after adding the land use layer and adjusting parameter rates using the Wilcoxon method. These findings offer valuable insights for accurately assessing groundwater vulnerability in areas with similar hazards and hydrological conditions, particularly in semi-arid and arid regions. They contribute to improving groundwater and environmental management practices, ensuring the long-term sustainability of aquifers.
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Água Subterrânea , Nitratos , Humanos , Nitratos/análise , Monitoramento Ambiental/métodos , Água Subterrânea/análise , Abastecimento de Água , Poluição da Água/análiseRESUMO
PURPOSE: Studies are still ongoing to determine whether Helicobacter pylori (HP) may affect the results of laparoscopic sleeve gastrectomy (LSG). The main research objectives were HP prevalence in patients with severe obesity and the effects of HP status on outcomes. PATIENTS AND METHODS: This multicenter retrospective study included patients with severe obesity who had LSG. The patients were grouped into three groups based on the HP status of preoperative endoscopic biopsies and postoperative specimen results: group I (negative HP), group II (eradicated HP), and group III (positive HP). The primary outcome was the overall postoperative morbidities. RESULTS: One thousand six hundred fifteen patients who underwent LSG for severe obesity were included in this study. Seven hundred fifty (46.4%) patients had negative HP, and 637 (39.4%) patients had eradicated HP, whereas 228 (14.1%) patients had positive HP. The antral and gastric body wall thickness was significantly noticed with positive HP. The groups had no significant differences regarding postoperative complication frequency, severity, and hospital mortality. The rates of gastric leakage in the three groups do not differ significantly. BMI > 50, gastropexy, gastric thickness, and antral resection were found to be independent risk factors for the occurrence of postoperative complications after LSG. There was no statistical significance as regards postoperative %TWL and %EWL among the three groups. CONCLUSION: The early results of LSG do not appear to be impacted by HP's status. The early postoperative course is unaffected by HP eradication anymore. Therefore, routine preoperative HP testing may not be as necessary, and management can be finished after LSG.
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Helicobacter pylori , Laparoscopia , Obesidade Mórbida , Humanos , Obesidade Mórbida/cirurgia , Estudos Retrospectivos , Laparoscopia/métodos , Gastrectomia/efeitos adversos , Gastrectomia/métodos , Obesidade/cirurgia , Prevalência , Complicações Pós-Operatórias/etiologia , Resultado do TratamentoRESUMO
Ventricular septal defect (VSD) is common in pediatric patients. This study aimed to evaluate the safety and effectiveness of using fast-track anesthesia and comparing it to traditional anesthesia, among children undergoing a transthoracic device closure for VSD. A systematic review following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. Relevant literature was identified through specific search terms in the Scopus, Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (Embase), Web of Science, The Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar databases. The inclusion criteria focused on observational studies that compared fast-track anesthesia with conventional anesthesia in pediatric VSD closure cases. Data extraction, quality assessment, and meta-analysis were performed using standard differences in means. Initially, 6,535 papers were identified, and subsequent screening of titles and abstracts led to the inclusion of four retrospective studies from a total of 51 studies. The analysis encompassed 477 patients, with 235 in the fast-track anesthesia group and 242 in the conventional anesthesia group. No statistically significant disparities were observed between the two groups concerning the operative duration and hemodynamic variations post-intubation or post-procedure (P >0.05). Nevertheless, the fast-track anesthesia group demonstrated significantly reduced healthcare expenses as well as shorter periods of mechanical ventilation, ICU stay, and overall hospitalization compared to conventional anesthesia (P <0.05). The use of fast-track anesthesia in combination with transthoracic device closure for VSD demonstrates a safe and effective approach for pediatric patients. This approach results in reduced healthcare costs (10,000 Renminbi (RMB)) and shorter durations of mechanical ventilation, ICU admission, and hospitalization compared to conventional anesthesia. Further clinical trials are necessary to confirm these results and assess long-term outcomes.
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This study introduces a metasurface (MS) based electrically small resonator for ambient electromagnetic (EM) energy harvesting. It is an array of novel resonators comprising double-elliptical cylinders. The harvester's input impedance is designed to match free space, allowing incident EM power to be efficiently absorbed and then maximally channelled to a single load through optimally positioned vias. Unlike the previous research works where each array resonator was connected to a single load, in this work, the received power by all array resonators is channelled to a single load maximizing the power efficiency. The performance of the MS unit cell, when treated as an infinite structure, is examined concerning its absorption and harvesting efficiency. The numerical results demonstrate that the MS unit cell can absorb EM power, with near-perfect absorption of 90% in the frequency range of 5.14 GHz to 5.5 GHz under normal incidence and with a fractional bandwidth of 21%. The MS unit cell also achieves higher harvesting efficiency at various incident angles up to 60o. The design and analysis of an array of 4x4 double elliptical cylinder MS resonators integrated with a corporate feed network are also presented. The corporate feed network connects all the array elements to a single load, maximizing harvesting efficiency. The simulation and measurement results reveal an overall radiation to AC efficiency of about 90%, making it a prime candidate for energy harvesting applications.
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Eletricidade , Radiação Eletromagnética , Simulação por Computador , Impedância ElétricaRESUMO
Gelatin derived from marine by-products could be an interesting alternative to classic mammalian gelatin. The pretreatment and extraction conditions could influence the size of the resulting peptide chains and therefore their techno-functional properties. Thus, it is important to optimize the production process to get a gelatin for the appropriate applications. Skin pretreatment was done by microwaves or oven-drying and the extracted gelatin was dried by spray- or freeze-drying. Freeze-dried gelatin extracted from untreated skin (FGUS) had the highest gelatin yield (10.40%). Gelatin proximate composition showed that proteins were the major component (87.12-89.95%), while lipids showed the lowest contents (0.65-2.26%). Glycine showed the highest level (299-316/1000 residues) in the extracted gelatins. Proline and hydroxyproline residues of gelatins from untreated skin were significantly higher than those from pretreated skin-gelatin. FTIR spectra were characterized by peaks of the amide A (3430-3284 cm-1), B (3000-2931 cm-1), I (1636-1672 cm-1), II (1539-1586 cm-1) and III (1000-1107 cm-1). Spray-drying decreased the gelling properties of gelatins, since it reduced gelling and melting temperatures compared to freeze-drying. Skin pretreatment significantly reduced the gel strength of gelatin by about 50-100 g depending on the gelatin drying method. The FGUS showed better surface properties compared to other gelatins. The highest emulsion activity index (39.42 ± 1.02 m2/g) and foaming expansion (172.33 ± 2.35%) were measured at 3% FGUS. Therefore, the promising properties of freeze-dried gelatin derived from untreated skin, gave it the opportunity to be successfully used as a techno-functional ingredient in many formulations.
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INTRODUCTION: There is growing interest in Mindfulness-based Stress Reduction (MBSR) program to combat mental distress in medical students. In Saudi Arabia, literature is insufficient about MBSR and its effectiveness. This study aims to measure the effectiveness of MBSR in improving mindful state, stress, anxiety, and depression in medical students. Also, the study explores the association between the attendance rate of MBSR sessions and its effectiveness. Lastly, the study examines gender differences in response to MBSR. METHODS: This is a stratified randomized controlled study of 84 medical students from two medical schools in Riyadh, Saudi Arabia. They were recruited voluntarily from November 2018 to April 2021, and allocated to MBSR and waitlist groups using a stratified randomization method based on gender. MBSR group received eight weeks of sessions through audiovisual materials. An online survey utilizing validated questionnaires assessing stress, mindfulness, anxiety, and depression was used to evaluate both groups pre-program (time 0), post-program (time 1), and three months later (time 2). RESULTS: Seventy-one participants completed the post-test (time 1). There were no differences between study groups at time 0 and 1. However, in 41 subjects who completed the follow-up test (time 2), the anxiety dropped significantly in MBSR group (mean difference (MD), -3.935; 95% CI, -7.580 to -0.290). Furthermore, attending more MBSR sessions was inversely correlated with depression (r, -0.556; P, 0.002), and anxiety (r, -0.630; P, 0.000). Compared to their baseline, males in MBSR group improved in stress (MD, 3.08; 95% CI, 0.30 to 5.86), anxiety (MD, 4.91; 95% CI, 3.32 to 6.50), and mindfulness (MD, -0.58; 95% CI, -1.01 to -0.15), while females improved in stress (MD, 2.64; 95% CI, 0.02 to 5.26). CONCLUSION: Despite the study being interrupted by the stressful COVID-19 outbreak, the findings suggest that MBSR improved psychological outcomes when participants commit to the program.
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Atenção Plena , Estudantes de Medicina , Masculino , Feminino , Humanos , Depressão/terapia , Depressão/psicologia , Atenção Plena/métodos , Estresse Psicológico/terapia , Estresse Psicológico/psicologia , Ansiedade/terapia , Ansiedade/psicologiaRESUMO
PURPOSE: Postoperative nausea and vomiting (PONV) is a frequent unappealing laparoscopic sleeve gastrectomy (LSG) sequel. The study's purpose was to determine the prevalence, risk factors of PONV, and management of PONV after LSG. PATIENTS AND METHODS: This multicenter retrospective study included patients with morbid obesity who had LSG between January 2022 and April 2023. The age range for LSG was 16 to 65 years, and the eligibility requirements included morbid obesity according to international guidelines. RESULTS: PONV was experienced by 74.6% of patients who underwent LSG at 6 h postoperative. Multivariate analysis revealed that female gender, smokers, preoperative GERD, gastropexy, and severity of pain were found to be independent risk variables of the development of PONV, while antral preservation, opioid-free analgesia, and intraoperative combined analgesia were found to be independent protective variables against the development of PONV. Combined intravenous ondansetron and metoclopramide improved 92.6% of patients who developed PONV. Dexamethasone and antihistamines drugs are given for 42 cases with persistent PONV after using intravenous ondansetron and metoclopramide. Pain management postoperatively by opioid-free analgesia managed PONV. Helicobacter pylori status has no role in the development of PONV after LSG. CONCLUSION: Female gender, smoking, presence of preoperative GERD, gastropexy, and severity of pain were found to be independent risk variables of the development of PONV, while antral preservation, opioid-free analgesia, and intraoperative combined analgesia were observed to be independent protective factors against the occurrence of PONV. Combined intravenous ondansetron and metoclopramide improved PONV. Dexamethasone and antihistamines drugs are given for persistent PONV.
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Refluxo Gastroesofágico , Laparoscopia , Obesidade Mórbida , Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Náusea e Vômito Pós-Operatórios/epidemiologia , Estudos Retrospectivos , Metoclopramida , Ondansetron/uso terapêutico , Prevalência , Obesidade Mórbida/cirurgia , Fatores de Risco , Dor , Analgésicos Opioides/uso terapêutico , Gastrectomia/efeitos adversos , Dexametasona , Laparoscopia/efeitos adversosRESUMO
Urban surfaces are often covered by impermeable materials such as concrete and asphalt which intensify urban runoff and pollutant concentration during storm events, and lead to the deterioration of the quality of surrounding water bodies. Detention ponds are used in urban stormwater management, providing two-fold benefits: flood risk reduction and pollution load minimization. This paper investigates the performance of nine proposed detention ponds (across the city of Renton, Washington, USA) under different climate change scenarios. First, a statistical model was developed to estimate the pollutant load for the current and future periods and to understand the effects of increased rainfall on stormwater runoff and pollutant loads. The Personal Computer Storm Water Management Model (PCSWMM) platform is employed to calibrate an urban drainage model for quantifying stormwater runoff and corresponding pollutant loads. The calibrated model was used to investigate the performance of the proposed nine (9) detention ponds under future climate scenarios of 100-year design storms, leading to identifying if they are likely to reduce stormwater discharge and pollutant loads. Results indicated significant increases in stormwater pollutants due to increases in rainfall from 2023 to 2050 compared to the historical period 2000-2014. We found that the performance of the proposed detention ponds in reducing stormwater pollutants varied depending on the size and location of the detention ponds. Simulations for the future indicated that the selected detention ponds are likely to reduce the concentrations (loads) of different water quality constituents such as ammonia (NH3), nitrogen dioxide (NO2), nitrate (NO3), total phosphate (TP), and suspended solids (SS) ranging from 18 to 86%, 35-70%, 36-65%, 26-91%, and 34-81%, respectively. The study concluded that detention ponds can be used as a reliable solution for reducing stormwater flows and pollutant loads under a warmer future climate and an effective adaptation option to combat climate change related challenges in urban stormwater management.
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Land-use/land-cover (LULC) change is considered a key human factor influencing groundwater recharge in floodplains. Without accurate estimations, the impact of LULC change on water balance components may be either significantly understated or exaggerated. This paper assesses the impacts of LULC changes from 1990 to 2018 on water balance components and groundwater levels of the Drava floodplain, Hungary, where human interference has led to a critical environmental situation. In this study, a spatially-distributed water balance model (WetSpass-M), and a groundwater flow model (MODFLOW-NWT) were integrated to assess the impacts of LULC changes. The moderate expansion of built-up areas increased surface runoff, while the afforestation of arable land and meadows and the overgrowth of bare mudflats with willow shrubs increased evapotranspiration. As a consequence, total annual groundwater recharge decreased by 5.3 × 107 m3 in the floodplain with an average of 335 mm year-1 and 317 mm year-1 in 2012 and 2018, respectively. Moreover, an average groundwater level decline by 0.1 m is observed in the same period. Declined groundwater recharge, increased runoff, and evapotranspiration exerted a negative effect on water resources in the Drava basin. The approach tested in this paper allows temporal and spatial estimation of hydrological components under the changes of LULC, providing quantitative information for decision-makers and stakeholders to implement efficient and sustainable management of water resources in the Drava floodplain. The provided integrated model is also applicable to regionally.
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Introduction: This work presents proteins, amino acids profiles and antioxidant and properties of camel and cow milk fractions produced using an integrated coagulation-centrifugation process. Methods: Antioxidant activity using DPPH radical scavenging assay; and antidiabetic activity antidiabetic activity using in vitro α-amylase inhibitory activity were assessed on defatted milk fractions and their extracts using water/ethanol or HCl/ethanol solvents. Protein profiles and amino acids composition were analyzed by high-performance liquid chromatography. Results and discussions: The predominant protein found in cow and camel milk was ß-casein in sodium caseinate, ß-lactoglobulin was found in the whey of cow milk, whereas α-lactalbumin was detected in the whey fractions of camel. The primary amino acids (comprising 1% to 5.2%) in skim milk and sweet whey milk were leucine, proline, and lysine. However, acid whey, casein fractions (sodium caseinate, and ß-casein) from both camel and cow milk exhibited elevated concentrations of histidine, leucine, lysine and proline (1.12 - 6.62%). Camel milk and its different protein fractions showed an interesting in vitro α-amylase inhibitory activity varying, according to different milk fractions and extraction methods, from 19.10 ± 1.40 to 97.40 ± 1.50%. Whatever the used method, the whey fractions from camel milk, both acid and sweet, displayed ed the highest antioxidant activity. Principal components analysis showed a positive correlation between the total phenols content, antioxidant (DPPH assay) and antidiabetic (α amylase inhibition test) activities within the milk fractions. Sweet and acid cow milk fractions seem to be the most promising for deeper exploration of in vivo biological activities and are promising milk derivatives for specific nutritional diet and/or functional food formulation.
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Ventilator-associated pneumonia (VAP) is a common healthcare-associated disease in intensive care units, leading to significant morbidity and mortality. This systematic review aims to investigate the prevalence, risk factors, and prevention strategies for VAP in the Middle East. PubMed, SCOPUS, Web of Science, Science Direct, and Google Scholar were systematically searched to include the relevant literature. Rayyan QCRI was used throughout this systematic approach. Ten studies, involving a total of 6295 patients diagnosed with VAP, were included in this review. Among these patients, 336 (5.3%) developed VAP. The prevalence of VAP in children and neonates in the Middle East was relatively low. Risk factors associated with VAP development included prematurity, low birth weight, prolonged mechanical ventilation, enteral feeding, intrusive devices such as umbilical catheters, and cardiac operations. All reviewed studies emphasized the importance of infection control measures in reducing the risk of VAP.
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An edible coating was developed using gelatin extracted from the skin of gray triggerfish (Balistes capriscus) and applied to the fillet of the smooth-hound shark (Mustelus mustelus). Moringa oleifera leaf extract was added to gelatin coating solution to improve its preservative properties. The phenolic profiles and antioxidant and antibacterial activities of M. oleifera extracts were determined. Phenolic acids constituted the largest group representing more than 77% of the total compounds identified in the ethanol/water (MOE/W) extract, among which the quinic acid was found to be the major one (31.48 mg/g extract). The MOE/W extract presented the highest DPPH⢠scavenging activity (IC50 = 0.53 ± 0.02 mg/ml) and reducing (Fe3+) power (EC0.5 = 0.57 ± 0.02 mg/ml), as well as interesting inhibition zones (20-35 mm) for the most tested strains. Coating by 3% of gelatin solution significantly reduced most deterioration indices during chilled storage, such as malondialdehyde (MDA), total volatile basic nitrogen (TVB-N), weight loss, pH, and mesophilic, psychrophilic, lactic, and H2S-producing bacterial counts. Interestingly, coating with gelatin solution containing MOE/W extract at 20 µg/ml was more effective than gelatin applied alone. Compared with the uncoated sample, gelatin-MOE/W coating reduced the weight loss and MDA content by 26% and 70% after 6 days of storage, respectively. Texture analysis showed that the strength of uncoated fillet increased by 46%, while the strength of fillet coated with gelatin-MOE/W only increased by 12% after 6 days of storage. Fish fillet coated with gelatin-MOE/W had the highest sensory scores in terms of odor, color, and overall acceptability throughout the study period.
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Insulator monitoring using leakage current characteristics is essential for predicting an insulator's health. To evaluate the risk of flashover on the porcelain insulator using leakage current, experimental investigation of leakage current indices was carried out. In the first stage of the experiment, the effect of contamination, insoluble deposit density, wetting rate, and uneven distribution pollution were determined on the porcelain insulator under test. Then, based on the laboratory test results, leakage current information in time and frequency characteristics was extracted and employed as assessment indicators for the insulator's health. Six indicators, namely, peak current indicator, phase shift indicator, slope indicator, crest factor indicator, total harmonic distortion indicator, and odd harmonics indicator, are introduced in this work. The obtained results indicated that the proposed indicators had a significant role in evaluating the insulator's health. To evaluate the insulator's health levels based on the extracted indicator values, this work presents the naïve Bayes technique for the classification and prediction of the insulator's health. Finally, the confusion matrix for the experimental and prediction results for each indicator was established to determine the appropriateness of each indicator in determining the insulator's health status.