1.
Bioorg Med Chem Lett
; 12(5): 763-6, 2002 Mar 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11858997
RESUMO
Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead, demonstrating that a peptide backbone is not essential for activity.