RESUMO
The progress of PD and its related disorders cannot be prevented with the medications available. In this study, we recruited 8 PD and 4 PD plus patients between 5 to 15 years after diagnosis. All patients received BM-MSCs bilaterally into the SVZ and were followed up for 12 months. PD patients after therapy reported a mean improvement of 17.92% during "on" and 31.21% during "off" period on the UPDRS scoring system. None of the patients increased their medication during the follow-up period. Subjectively, the patients reported clarity in speech, reduction in tremors, rigidity, and freezing attacks. The results correlated with the duration of the disease. Those patients transplanted in the early stages of the disease (less than 5 years) showed more improvement and no further disease progression than the later stages (11-15 years). However, the PD plus patients did not show any change in their clinical status after stem cell transplantation. This study demonstrates the safety of adult allogenic human BM-MSCs transplanted into the SVZ of the brain and its efficacy in early-stage PD patients.
RESUMO
Two females, in their sixth decade, presented with recurrent episodes of headache, vertigo, vomiting and altered sensorium. Both patients had persistent hyponatraemia as the only clue. Detailed investigations revealed a pituitary aetiology in both. One patient had a pituitary microadenoma while the other had an empty sella syndrome. The diagnosis and management is discussed and the relevant literature reviewed.
Assuntos
Adenoma/complicações , Síndrome da Sela Vazia/complicações , Hiponatremia/etiologia , Neoplasias Hipofisárias/complicações , Idoso , Feminino , HumanosRESUMO
Neurosarcoidosis is rare, accounting for less than 5 percent of all cases of sarcoidosis. We report a case of neurosarcoidosis presenting with neuropsychiatric features and meningitis, confirmed by meningeal biopsy. The difficulties encountered in establishing the diagnosis and treatment are highlighted.