Escala de estratégias de enfrentamento para pacientes oncológicos: desenvolvimento de uma medida / Coping strategies scale for cancer patients: development of a measurement / Escala de estrategias de enfrentamiento para pacientes oncológicos: desarrollo de una medida

O objetivo desse estudo foi desenvolver um instrumento capaz de avaliar o enfrentamento de pacientes oncológicos. Foram construídos 112 itens que passaram por análise teórica de juízes especialistas e pré-teste com o público-alvo. Os 42 que restaram após essas etapas foram respondidos por 392 pacientes oncológicos. A análise de validade de estrutura interna foi realizada por análise fatorial exploratória. Denominada como Escala de Estratégias de Enfrentamento para Pacientes Oncológicos (E3PO), os resultados indicaram uma estrutura de 20 itens divididos em dois fatores que explicam 36,05% da variância total. Engajamento no Tratamento, 14 itens (confiabilidade composta de 0,83), avalia compromisso orientado para mudança do estressor. Reações Emocionais, seis itens (confiabilidade composta de 0,75), avalia enfrentamento baseado na expressão de sentimentos negativos advindos do estressor. A E3PO pode futuramente auxiliar na elaboração de planos terapêuticos e avaliação de intervenções comportamentais que tenham como foco o desenvolvimento ou melhoramento do enfrentamento ao câncer.(AU)

This study aimed to develop a scale to evaluate coping strategies in cancer patients. Initially, 112 items were created and subjected to theoretical analysis by expert judges, followed by a trial with the target population. After these steps, 42 items remained and were answered by 392 cancer patients. An exploratory factor analysis was conducted to assess the scale's Internal structure validity. The resulting Coping Strategies Scale for Cancer Patients (E3PO) consists of 20 items grouped into two factors, explaining 36.05% of the total variance. The first factor, Treatment Engagement, includes 14 items (with a composite reliability of .83), which measure commitment to addressing the stressor. The second factor, Emotional Reactions, includes six items (with a composite reliability of .75) that evaluate coping based on the expression of negative emotions coming from the stressor. In the future, E3PO may help in the development of therapeutic plans and the evaluation of behavioral interventions aimed at enhancing coping strategies among cancer patients.(AU)

El objetivo de este estudio fue desarrollar una herramienta para evaluar el afrontamiento de pacientes oncológicos. Se construyeron 112 ítems que fueron sometidos a análisis teórico por parte de jueces especialistas y prueba piloto con la población objetivo. Los 42 ítems restantes tras esta etapa fueron contestados por 392 pacientes oncológicos. El análisis de la validez de la estructura interna se hizo por análisis factorial exploratorio. Denominad Escala de Estrategias de Afrontamiento para Pacientes Oncológicos (E3PO), los resultados señalaron una estructura de 20 ítems divididos en dos factores que explican 36.05% de la varianza total. Compromiso con el Tratamiento con 14 ítems (fiabilidad compuesta .83) evalúa el compromiso orientado hacia el cambio del estresor. Reacciones Emocionales con seis ítems (fiabilidad compuesta .75) evalúa el afrontamiento basado en la expresión de sentimientos negativos derivados del estresor. En el futuro, E3PO puede ser útil en la elaboración de planes terapéuticos y en la evaluación de intervenciones conductuales que se centren en el desarrollo o la mejora del afrontamiento del cáncer.(AU)

Strategies to combat COVID-19 in long -term care facilities for older people.

OBJECTIVE: To describe the strategies to combat COVID-19 in Long-Term Care Facilities for older people in Bahia state. METHODOLOGY: This is a qualitative study based on documentary analysis of the collection produced by the Intersectoral Committee on Monitoring Long-Term Care for older people in the state of Bahia, from April 2020 to June 2021. Data analysis was based on Bardin's content analysis. RESULTS: The commission produced seven documents in the period analyzed. Two thematic categories emerged: Intersectoral Networks and Telemonitoring of Long-Term Care Facilities for the Elderly. CONCLUSION: The coordination in an intersector network and the telemonitoring carried out by the Intersector Committee on Monitoring Long-Term Care Facilities were the main strategies to fight COVID-19 in these institutions. The need to implement effective public policies to support long-term care facilities for older people is highlighted.

Efficacy of treatment of class II furcation lesions using membrane associated with bone grafting in mandibular molars compared to membrane only: a systematic review and meta-analysis / Eficacia del tratamiento de lesiones de furca grado II utilizando membrana asociada con injerto óseo en molares mandibulares en comparación con solamente membrana: revisión sistemática y metanálisis

Objective: The objective of the present systematic review and meta-analysis was to compare treatment with membrane associated with bone grafting and treatment exclusively with membrane in the approach of Class II furcation defects in mandibular molars. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed. Searches were conducted in five databases (PubMed, Web of Science, Scopus, Ovid, and Lilacs), in Septem-ber 2021, without restriction regarding publication year or language. Studies comparing membranes associated with bone grafting and membranes exclusively in the treatment of Class II furcation lesions were included. Cross-sectional, case-control studies, and reviews were excluded. Study selection, data extraction, and risk of bias assessment (MINORS) were performed by two review authors. The certainty of the evidence (GRADE) was evaluated and meta-analysis was performed. Mean difference (MD) and 95% confidence interval (CI) were provided. Results: Four hundred eighty-six references were iden-tified and four studies were included. Greater reduction in probing depth [MD = 0.32 (CI = 0.09, 0.56)] and greater clinical attachment level gain [MD = 0.41 (CI = 0.24, 0.57)] were observed when membrane and bone grafting were used. The risk of bias of included studies was low. Conclusions: This present systematic review and meta-analysis demonstrated that treatment of Class II furcation defects in mandibular molars using membrane and bone grafing is significantly more efficacious than treatment with the exclusive use of membrane.

Objetivo: El objetivo de la presente revisión sistemática y metanálisis fue comparar el tratamiento con membrana asociado a injerto óseo y el tratamiento exclusivamente con membrana en el abordaje de lesiones de furca grado II en molares mandibulares. Materiales y Métodos: Se siguió la declaración de elementos de informe preferidos para revisiones sistemáticas y metanálisis (PRISMA). Las búsquedas se realizaron en cinco bases de datos (PubMed, Web of Science, Scopus, Ovid y Lilacs), en septiembre de 2021, sin restricción de año de publicación o idioma. Se incluyeron estudios que compararon membranas asociadas con injertos óseos y membranas exclusivamente en el tratamiento de lesiones de furca de grado II. Se excluyeron los estudios transversales, de casos y controles y las revisiones. Dos revisores realizaron la selección de estudios, la extracción de datos y la evaluación del riesgo de sesgo (MINORS). Se evaluó la certeza de la evidencia (GRADE) y se realizó un metanálisis. Se proporcionaron la diferencia de medias (DM) y el intervalo de confianza (IC) del 95%. Resultados: Se identificaron 486 referencias y se incluyeron cuatro estudios. Se observó una mayor reducción en la profundidad de sondaje [DM = 0,32 (IC = 0,09, 0,56)] y una mayor ganancia en el nivel de inserción clínica [DM = 0,41 (IC= 0,24, 0,57)] cuando se utilizaron injertos de membrana y hueso. El riesgo de sesgo de los estudios incluidos fue bajo. Conclusión: La presente revisión sistemática y metanálisis demostró que el tratamiento de los defectos de furca de grado II en molares mandibulares utilizando membrana e injertos de hueso es significativamente más eficaz que el tratamiento con el uso exclusivo de membrana.

Viruses of sulfur oxidizing phototrophs encode genes for pigment, carbon, and sulfur metabolisms.

Viral infections modulate bacterial metabolism and ecology. Here, we investigated the hypothesis that viruses influence the ecology of purple and green sulfur bacteria in anoxic and sulfidic lakes, analogs of euxinic oceans in the geologic past. By screening metagenomes from lake sediments and water column, in addition to publicly-available genomes of cultured purple and green sulfur bacteria, we identified almost 300 high and medium-quality viral genomes. Viruses carrying the gene psbA, encoding the small subunit of photosystem II protein D1, were ubiquitous, suggesting viral interference with the light reactions of sulfur oxidizing autotrophs. Viruses predicted to infect these autotrophs also encoded auxiliary metabolic genes for reductive sulfur assimilation as cysteine, pigment production, and carbon fixation. These observations show that viruses have the genomic potential to modulate the production of metabolic markers of phototrophic sulfur bacteria that are used to identify photic zone euxinia in the geologic past.

Humoral immunity is not altered in overweight pregnant Crioulo mares / Imunidade humoral não é alterada em éguas Crioulas gestantes com sobrepeso

Both pregnancy and obesity can influence significant changes in the immune system. On this basis, the present study proposes to evaluate the humoral immune response of overweight pregnant mares in response to a commercial vaccine. Thirty pregnant Crioulo mares were separated according to body condition score (BCS) into overweight (BCS≥7/9) or lean-control (BCS= 5-6/9). In each group, the animals were subdivided into vaccinated and controls. The mares were vaccinated against EHV-1 in two doses spaced 21 days apart and had their blood collected monthly, for five months, for antibody evaluation. Both vaccinated groups had an increase in specific neutralizing antibodies after the vaccine. However, after the second dose, there was no increase in antibodies in any of the groups. Vaccinated overweight and lean-control mares did not differ at any time point. Therefore, this study demonstrated that obesity does not influence the humoral immune response in pregnant Crioulo mares.(AU)

Tanto a gestação quanto a obesidade podem influenciar o desenvolvimento de alterações significativas no sistema imune, portanto, o presente estudo teve como objetivo avaliar a resposta imune humoral de éguas gestantes com sobrepeso em resposta a uma vacina comercial. Trinta éguas Crioulas gestantes foram separadas de acordo com o escore de condição corporal (ECC) em éguas com sobrepeso (ECC≥7/9) e éguas controles (ECC=5-6/9) e, ainda, em cada grupo, os animais também foram separados em vacinados e controles. As éguas foram vacinadas contra o EHV-1 em duas doses com intervalo de 21 dias, sendo realizadas coletas de sangue mensalmente durante cinco meses para avaliação de anticorpos neutralizantes. Ambos os grupos vacinados tiveram aumento de anticorpos neutralizantes específicos após a vacina, porém, após a segunda dose, não foi observado aumento de anticorpos em nenhum dos grupos. Nenhuma diferença foi observada entre éguas vacinadas com sobrepeso e as éguas controles em nenhum momento. Assim, este estudo demonstrou que a obesidade não é um fator que influencia a resposta imune humoral de éguas Crioulas gestantes.(AU)

Endodontic techniques with Nickel Titanium instruments: analysis of quality and efficiency of instrumentation in primary molars / Técnicas endodônticas com instrumentos de Níquel Titânio: análise da qualidade e eficiência da instrumentação em molares decíduos

ABSTRACT Objective: The purpose of the present in vitro study was to evaluate the efficiency of three different instruments in the root canals of artificial primary molars as well as the quality of the fillings. Methods: Sixty artificial primary molars were divided into three groups of 20 teeth. Each group was submitted to a different technique: Group 1 - conventional manual technique using Kerr files; Group 2 - manual technique with nickel-titanium files; Group 3 - NiTi rotary technique. The root canals were filled with calcium hydroxide paste. Aspects such as homogeneity of the fillings, taper and flowability of the preparations were considered comparatively to assess the quality of the instrumentations. The non-parametric Kruskal-Wallis and Mann-Whitney tests were used to compare the efficiency of the preparation of the root canal considering the preparation times of them. Results: All three techniques were equally effective at shaping the root canals of primary teeth. The working time was shorter with the rotary instrument (p=0.000). In the pairwise comparisons, working time was shorter with the rotary instrument compared to the manual techniques with steel files (p=0.000) and NiTi files (p=0.000). Comparing the manual techniques, the working time was shorter with NiTi files compared to steel files (p=0.011). Moreover, less variability in the preparation time was found when the rotary instrument was used. Conclusions: The mechanized rotary method led to a shorter operating time in comparison to the manual techniques and is therefore a preferable option for the preparation of the root canals of primary teeth.

RESUMO Objetivo: Avaliar a eficiência de três instrumentos diferentes nos canais radiculares de molares decíduos artificiais, bem como a qualidade das obturações. Métodos: Sessenta molares decíduos artificiais foram divididos em três grupos de 20 dentes. Cada grupo foi submetido a uma técnica diferente: Grupo 1 - técnica manual convencional com limas Kerr; Grupo 2 - técnica manual com limas de níquel-titânio; Grupo 3 - Técnica rotatória de níquel-titânio. Os canais radiculares foram preenchidos com pasta de hidróxido de cálcio. Aspectos como homogeneidade das obturações, conicidade e fluidez das preparações foram considerados comparativamente para avaliar a qualidade das instrumentações. Os testes não paramétricos de Kruskal-Wallis e Mann-Whitney foram utilizados para comparar a eficiência do preparo do canal radicular considerando os tempos de preparo dos mesmos. Resultados: Todas as três técnicas foram igualmente eficazes na modelagem dos canais radiculares. O tempo de trabalho foi menor com o instrumento rotatório (p=0,000). Nas comparações pareadas, o tempo de trabalho foi menor com o instrumento rotatório em comparação com as técnicas manuais com limas de aço (p=0,000) e limas de NiTi (p=0,000). Comparando as técnicas manuais, o tempo de trabalho foi menor com as limas de NiTi em comparação com as limas de aço (p=0,011). Além disso, foi encontrada menor variabilidade no tempo de preparo quando o instrumento rotatório foi utilizado. Conclusão: O método rotatório levou um menor tempo operatório em comparação com as técnicas manuais e, portanto, é uma opção preferível para o preparo dos canais radiculares de dentes decíduos.

Strategies to combat COVID-19 in long -term care facilities for older people / Estrategias para combatir el COVID-19 en centro de cuidados a largo plazo para ancianos / Estratégias de enfrentamento à COVID-19 em instituições de longa permanência para idosos

ABSTRACT Objective To describe the strategies to combat COVID-19 in Long-Term Care Facilities for older people in Bahia state. Methodology This is a qualitative study based on documentary analysis of the collection produced by the Intersectoral Committee on Monitoring Long-Term Care for older people in the state of Bahia, from April 2020 to June 2021. Data analysis was based on Bardin's content analysis. Results The commission produced seven documents in the period analyzed. Two thematic categories emerged: Intersectoral Networks and Telemonitoring of Long-Term Care Facilities for the Elderly. Conclusion The coordination in an intersector network and the telemonitoring carried out by the Intersector Committee on Monitoring Long-Term Care Facilities were the main strategies to fight COVID-19 in these institutions. The need to implement effective public policies to support long-term care facilities for older people is highlighted.

RESUMEN Objetivo Describir las estrategias de enfrentamiento a COVID-19 en Instituciones de Larga Permanencia para Ancianos en el estado de Bahia. Metodología Se trata de una investigación retrospectiva, por medio de un análisis documental del acervo producido por la Comisión Intersectorial de Monitoreo de Instituciones de Larga Permanencia para Ancianos en el Estado de Bahía, en el período de abril/2020 a junio/2021. El tratamiento de los datos se basó en el análisis de contenido de Bardin. Resultados Surgieron dos categorías temáticas: Articulación en red Intersectorial y telemonitorización de instituciones de larga permanencia para ancianos. Conclusión Se concluyó que el conjunto de acciones de articulación en red intersectorial y telemonitoramiento realizadas por la Comisión Intersectorial de Monitoreo de Larga Permanencia fueron estrategias fundamentales para mitigar el impacto de COVID-19 en las instituciones. Se destaca la necesidad de implementación de políticas públicas efectivas de apoyo a las instituciones de larga permanencia para ancianos, repensar críticamente sobre la tipología de estos equipos.

RESUMO Objetivo Descrever as estratégias de enfrentamento à COVID-19 em Instituições de Longa Permanência para Idosos no estado da Bahia. Metodologia Trata-se de uma pesquisa retrospectiva, por meio de uma análise documental do acervo produzido pela Comissão Intersetorial de Monitoramento de Instituições de Longa Permanência para Idosos no Estado da Bahia, no período de abril/2020 a junho/2021. O tratamento dos dados baseou-se na análise de conteúdo de Bardin. Resultados Emergiram duas categorias temáticas: Articulação em rede Intersetorial e telemonitoramento de instituições de longa permanência para idosos. Conclusão Concluiu-se que o conjunto de ações de articulação em rede intersetorial e telemonitoramento realizadas pela Comissão Intersetorial de Monitoramento de Longa Permanência foram estratégias fundamentais para mitigar o impacto da COVID-19 nas instituições. Destaca-se a necessidade de implementação de políticas públicas efetivas de apoio às instituições de longa permanência para idosos, repensando criticamente sobre a tipologia destes equipamentos.

Spiritual care provided by the nursing team to the person in palliation in intensive care.

OBJECTIVE: To understand how the spiritual care provided by the nursing team to the person undergoing palliation in the Intensive Care Unit occurs. METHOD: Study with a qualitative approach, conducted in an Intensive Care Unit in Salvador, Bahia. Data collection took place through semi-structured interviews between January and May 2019. 14 nurses and 21 nursing technicians participated in the study. The data were submitted to Bardin Content Analysis and analyzed in the light of the Peaceful End of Life Theory. RESULTS: Two categories emerged: 1. Spiritual care provided through words of optimism, encouragement of faith and prayer; 2. Care provided through attention to spiritual needs and assurance of comfort. FINAL CONSIDERATIONS: Although empirically and not aware of the spiritual care provided, the nursing team offers support with words of optimism, faith, moments of prayer and contributes to the spiritual comfort of the person in palliation.

Dental students' satisfaction with their course and how it is associated to their satisfaction with life and career outlook / Satisfação com o curso de Odontologia e suas associações com a satisfação com a vida e perspectiva de carreira

ABSTRACT Identifying factors that influence the satisfaction of undergraduate dental students can contribute to establishing strategies for improving the educational process, furthering student development, and enhancing students' academic and professional achievements. Aim: the present study investigated associations between undergraduate students' satisfaction with the dental course and their satisfaction with life, perception of professional career and sociodemographic factors. Materials and method: this was a cross-sectional study on 512 dental students from a Brazilian School of Dentistry. Students were asked to respond to three questionnaires about sociodemographic characteristics, academic, and professional perceptions. Satisfaction with life was measured using the Brazilian version of the Satisfaction with Life Scale, which comprises five statements with responses scored on a seven-point Likert scale ranging from "I strongly disagree" to "I strongly agree". Unadjusted and adjusted multiple logistic regression analyses were performed to test associations between satisfaction with the dental course and key variables. Results: most participants were female (73.2%), single (99.8%) and with mean age 21.77 (±2.71) years. Approximately three quarters had a family income over three times higher than the national monthly minimum wage. Higher satisfaction with the course was associated with more optimistic perception of the job market (OR=2.44; 95% CI: 1.36-4.40), better academic performance (OR=1.65; 95% CI: 1.00-2.74) and greater satisfaction with life (OR=1.10; 95% CI: 1.06-1.15). Students' sex and family income did not have significant impact on satisfaction with the dental course. Conclusions: satisfaction with the dental course is related to an optimistic perception of the job market, academic performance and satisfaction with life.

RESUMO Identificar os fatores que influenciam na satisfação dos estudantes de odontologia pode contribuir para o estabelecimento de estratégias que aprimorem o processo educacional, favorecendo o desenvolvimento dos alunos e potencializando suas conquistas acadêmicas e profissionais. Objetivo: o presente estudo investigou as associações entre a satisfação de estudantes de graduação com o curso de odontologia e sua satisfação com a vida, percepção da carreira profissional e fatores sociodemográficos. Materiais e método: um estudo transversal foi realizado com 512 estudantes de Odontologia de uma Faculdade Brasileira de Odontologia. Três questionários foram aplicados aos alunos, com o objetivo de avaliar as características sociodemográficas, percepções acadêmicas e profissionais. A satisfação com a vida foi mensurada pela versão brasileira da Escala de Satisfação com a Vida, que compreende cinco afirmações com respostas pontuadas em uma escala Likert de sete pontos, variando de "discordo totalmente" a "concordo totalmente". A análise de regressão logística foi realizada para testar associações entre a satisfação com o curso de Odontologia e as demais variáveis. Análises de regressão logística múltipla não-ajustada e ajustada foram realizadas para testar associações entre a satisfação com o curso de odontologia e variáveis-chave. Resultados: A maioria dos participantes era do sexo feminino (73,2%), solteiros (99,8%) e com média de idade de 21,77 (±2,71) anos. Aproximadamente três quartos tinham renda familiar três vezes superior ao salário-mínimo nacional. A maior satisfação dos alunos com o curso foi associada a maior percepção otimista do mercado de trabalho (OR=2,44; IC 95%: 1,36-4,40), desempenho acadêmico (OR=1,65; IC 95%: 1,00-2,74) e satisfação com a vida (OR =1,10; IC 95%: 1,06-1,15). O sexo dos alunos e a renda familiar não apresentaram impacto significativo na satisfação com o curso de odontologia. Conclusão: a satisfação com o curso de odontologia está relacionada com a percepção otimista do mercado de trabalho, desempenho acadêmico e satisfação com a vida.

Iron (oxyhydr)oxides shift the methanogenic community in deep sea methanic sediment - insights from long-term high-pressure incubations.

Intermittent increases of dissolved ferrous iron concentrations have been observed in deep marine methanic sediments which is different from the traditional diagenetic electron acceptor cascade, where iron reduction precedes methanogenesis. Here we aimed to gain insight into the mechanism of iron reduction and the associated microbial processes in deep sea methanic sediment by setting up long-term high-pressure incubation experiments supplemented with ferrihydrite and methane. Continuous iron reduction was observed during the entire incubation period. Intriguingly, ferrihydrite addition shifted the archaeal community from the dominance of hydrogenotrophic methanogens (Methanogenium) to methylotrophic methanogens (Methanococcoides). The enriched samples were then amended with 13C-labeled methane and different iron (oxyhydr)oxides in batch slurries to test the mechanism of iron reduction. Intensive iron reduction was observed, the highest rates with ferrihydrite, followed by hematite and then magnetite, however, no anaerobic oxidation of methane (AOM) was observed in any treatment. Further tests on the enriched slurry showed that the addition of molybdate decreased iron reduction, suggesting a link between iron reduction with sulfur cycling. This was accompanied by the enrichment of microbes capable of dissimilatory sulfate reduction and sulfur/thiosulfate oxidation, which indicates the presence of a cryptic sulfur cycle in the incubation system with the addition of iron (oxyhydr)oxides. Our work suggests that under low sulfate conditions, the presence of iron (oxyhydr)oxides would trigger a cascade of microbial reactions, and iron reduction could link with the microbial sulfur cycle, changing the kinetics of the methanogenesis process in methanic sediment.

Neurological impacts of covid-19 and worldwide scientific production about the subject: a bibliometric analysis / Impactos neurológicos da covid-19 e produção científica mundial sobre a temática: uma análise bibliométrica

Introduction: The novel Coronavirus (COVID-19) was first reported by officials in Wuhan City, in December 2019. It has rapidly spread with confirmed cases in almost every country across the world and has caused a global public health crisis.¹ The epidemiological update of the World Health Organization on 9th March 2021 showed that over 2.7 million new cases were reported. In this article, a biblometrical analysis of trending topics and what is being researched regarding COVID-19 and its neurological involvement is done. Methods: This research was conducted on the Web of Science Core Collection (WoS). For research in WoS, keywords in English were used, according to DeCS - Descriptors in Health Sciences. The search strategy with Boolean operators was: TS = (SARS-CoV-2 OR COVID-19) AND TS=(Neurologic Findings OR Neurology OR Neurologic Manifestations). Results: In total, 392 scientific productions were identified and included in this bibliometric analysis. The studies were published in the period between March 2020 and March 2021, with records prevalent in the themes of clinical neurology (n=234) and neurosciences (n=134), as well as several other areas. The thirty studies collected a total of 3395 citations, with variations from 1433 to 26 and average of 113 citations per study. All were published in 2020, with bigger prevalence in July (nine articles) and June (six articles). Conclusion: It is expected that this bibliometric survey will serve as a manner of presenting the main topics of study within neurology before COVID-19, in addition providing guidance for future research.

Introdução: O novo Coronavírus (COVID-19) foi relatado pela primeira vez por autoridades na cidade de Wuhan, em dezembro de 2019. Ele se espalhou rapidamente com casos confirmados em quase todos os países do mundo e causou uma crise global de saúde pública. A atualização epidemiológica da Organização Mundial da Saúde em 9 de março de 2021 mostrou que mais de 2,7 milhões de novos casos foram relatados. Neste artigo, é feita uma análise biblométrica dos trending topics e do que está sendo pesquisado sobre o COVID-19 e seu envolvimento neurológico. Métodos: Esta pesquisa foi realizada na Web of Science Core Collection (WoS). Para a pesquisa na WoS, foram utilizadas palavras-chave em inglês, conforme DeCS - Descritores em Ciências da Saúde. A estratégia de busca com operadores booleanos foi: TS = (SARS-CoV-2 OR COVID-19) AND TS= (Neurologic Findings OR Neurology OR Neurologic Manifestations). Resultados: No total, 392 produções científicas foram identificadas e incluídas nesta análise bibliométrica. Os estudos foram publicados no período entre março de 2020 e março de 2021, com registros prevalentes nos temas de neurologia clínica (n=234) e neurociências (n=134), além de diversas outras áreas. Os trinta estudos coletaram um total de 3.395 citações, com variações de 1.433 a 26 e média de 113 citações por estudo. Todos foram publicados em 2020, com maior prevalência em julho (nove artigos) e junho (seis artigos). Conclusão: Espera-se que este levantamento bibliométrico sirva como forma de apresentar os principais tópicos de estudo dentro da neurologia antes da COVID-19, além de fornecer orientações para pesquisas futuras.

Endophytic Trichoderma strains isolated from forest species of the Cerrado-Caatinga ecotone are potential biocontrol agents against crop pathogenic fungi.

The indiscriminate use of chemical pesticides increasingly harms the health of living beings and the environment. Thus, biological control carried out by microorganisms has gained prominence, since it consists of an environmentally friendly alternative to the use of pesticides for controlling plant diseases. Herein, we evaluated the potential role of endophytic Trichoderma strains isolated from forest species of the Cerrado-Caatinga ecotone as biological control agents of crop pathogenic fungi. Nineteen Trichoderma strains were used to assess the antagonistic activity by in vitro bioassays against the plant pathogens Colletotrichum truncatum, Lasiodiplodia theobromae, Macrophomina phaseolina, and Sclerotium delphinii isolated from soybean, cacao, fava bean, and black pepper crops, respectively. All Trichoderma strains demonstrated inhibitory activity on pathogen mycelial growth, with maximum percent inhibition of 70% against C. truncatum, 78% against L. theobromae, 78% against M. phaseolina, and 69% against S. delphinii. Crude methanol extracts (0.5 to 2.0 mg mL-1) of Trichoderma strains were able to inhibit the growth of C. truncatum, except Trichoderma sp. T3 (UFPIT06) and T. orientale (UFPIT09 and UFPIT17) at 0.5 mg mL-1, indicating that the endophytes employ a biocontrol mechanism related to antibiosis, together with multiple mechanisms. Discriminant metabolites of Trichoderma extracts were unveiled by liquid chromatography-tandem mass spectrometry-based metabolomics combined with principal component analysis (PCA), which included antifungal metabolites and molecules with other bioactivities. These results highlight the biocontrol potential of Trichoderma strains isolated from the Cerrado-Caatinga ecotone against crop pathogenic fungi, providing support for ongoing research on disease control in agriculture.

Dental students' satisfaction with their course and how it is associated to their satisfaction with life and career outlook.

Identifying factors that influence the satisfaction of undergraduate dental students can contribute to establishing strategies for improving the educational process, furthering student development, and enhancing students' academic and professional achievements. AIM: the present study investigated associations between undergraduate students' satisfaction with the dental course and their satisfaction with life, perception of professional career and sociodemographic factors. MATERIALS AND METHOD: this was a cross-sectional study on 512 dental students from a Brazilian School of Dentistry. Students were asked to respond to three questionnaires about sociodemographic characteristics, academic, and professional perceptions. Satisfaction with life was measured using the Brazilian version of the Satisfaction with Life Scale, which comprises five statements with responses scored on a seven-point Likert scale ranging from "I strongly disagree" to "I strongly agree". Unadjusted and adjusted multiple logistic regression analyses were performed to test associations between satisfaction with the dental course and key variables. RESULTS: most participants were female (73.2%), single (99.8%) and with mean age 21.77 (±2.71) years. Approximately three quarters had a family income over three times higher than the national monthly minimum wage. Higher satisfaction with the course was associated with more optimistic perception of the job market (OR=2.44; 95% CI: 1.36-4.40), better academic performance (OR=1.65; 95% CI: 1.00-2.74) and greater satisfaction with life (OR=1.10; 95% CI: 1.06-1.15). Students' sex and family income did not have significant impact on satisfaction with the dental course. CONCLUSIONS: satisfaction with the dental course is related to an optimistic perception of the job market, academic performance and satisfaction with life.

Identificar os fatores que influenciam na satisfação dos estudantes de odontologia pode contribuir para o estabelecimento de estratégias que aprimorem o processo educacional, favorecendo o desenvolvimento dos alunos e potencializando suas conquistas acadêmicas e profissionais. Objetivo: o presente estudo investigou as associações entre a satisfação de estudantes de graduação com o curso de odontologia e sua satisfação com a vida, percepção da carreira profissional e fatores sociodemográficos. Materiais e método: um estudo transversal foi realizado com 512 estudantes de Odontologia de uma Faculdade Brasileira de Odontologia. Três questionários foram aplicados aos alunos, com o objetivo de avaliar as características sociodemográficas, percepções acadêmicas e profissionais. A satisfação com a vida foi mensurada pela versão brasileira da Escala de Satisfação com a Vida, que compreende cinco afirmações com respostas pontuadas em uma escala Likert de sete pontos, variando de "discordo totalmente" a "concordo totalmente". A análise de regressão logística foi realizada para testar associações entre a satisfação com o curso de Odontologia e as demais variáveis. Análises de regressão logística múltipla não-ajustada e ajustada foram realizadas para testar associações entre a satisfação com o curso de odontologia e variáveis-chave. Resultados: A maioria dos participantes era do sexo feminino (73,2%), solteiros (99,8%) e com média de idade de 21,77 (±2,71) anos. Aproximadamente três quartos tinham renda familiar três vezes superior ao salário-mínimo nacional. A maior satisfação dos alunos com o curso foi associada a maior percepção otimista do mercado de trabalho (OR=2,44; IC 95%: 1,36-4,40), desempenho acadêmico (OR=1,65; IC 95%: 1,00-2,74) e satisfação com a vida (OR =1,10; IC 95%: 1,06-1,15). O sexo dos alunos e a renda familiar não apresentaram impacto significativo na satisfação com o curso de odontologia. Conclusão: a satisfação com o curso de odontologia está relacionada com a percepção otimista do mercado de trabalho, desempenho acadêmico e satisfação com a vida.

Spiritual care provided by the nursing team to the person in palliation in intensive care / Cuidado espiritual proporcionado por el equipo de enfermería a la persona en paliación en cuidados intensivos / Cuidado espiritual prestado pela equipe de enfermagem à pessoa em paliação na terapia intensiva

ABSTRACT Objective: To understand how the spiritual care provided by the nursing team to the person undergoing palliation in the Intensive Care Unit occurs. Method: Study with a qualitative approach, conducted in an Intensive Care Unit in Salvador, Bahia. Data collection took place through semi-structured interviews between January and May 2019. 14 nurses and 21 nursing technicians participated in the study. The data were submitted to Bardin Content Analysis and analyzed in the light of the Peaceful End of Life Theory. Results: Two categories emerged: 1. Spiritual care provided through words of optimism, encouragement of faith and prayer; 2. Care provided through attention to spiritual needs and assurance of comfort. Final considerations: Although empirically and not aware of the spiritual care provided, the nursing team offers support with words of optimism, faith, moments of prayer and contributes to the spiritual comfort of the person in palliation.

RESUMEN Objetivo: Comprender cómo ocurre el cuidado espiritual prestado por el equipo de enfermería a la persona en paliación en la Unidad de Cuidados Intensivos. Método: Estudio con enfoque cualitativo, realizado en una Unidad de Cuidados Intensivos en Salvador, Bahía. La recolección de datos ocurrió a través de entrevistas semiestructuradas entre enero y mayo de 2019. Participaron del estudio 14 enfermeros y 21 técnicos de enfermería. Los datos se sometieron al Análisis de Contenido de Bardin y se analizaron a la luz de la Teoría del Final Pacífico de la Vida. Resultados: surgieron dos categorías: 1. Atención espiritual a través de palabras de optimismo, estímulo de la fe y oración; 2. Atención a través de la atención a las necesidades espirituales y garantía de comodidad. Consideraciones finales: Aunque empíricamente y desconociendo el cuidado espiritual prestado, el equipo de enfermería ofrece apoyo con palabras de optimismo, fe, momentos de oración y contribuye al confort espiritual de la persona en paliativo.

RESUMO Objetivo: Apreender como ocorre o cuidado espiritual prestado pela equipe de enfermagem à pessoa em paliação na Unidade de Terapia Intensiva. Método: Estudo de abordagem qualitativa, realizado em uma Unidade de Terapia Intensiva em Salvador, Bahia. A coleta de dados ocorreu por entrevistas semiestruturadas entre janeiro e maio de 2019. Participaram do estudo 14 enfermeiras e 21 técnicas de enfermagem. Os dados foram submetidos à Análise de Conteúdo de Bardin e analisados à luz da Teoria Final de Vida Pacífico. Resultados: Emergiram duas categorias: 1. Cuidado espiritual prestado através de palavras de otimismo, estímulo a fé e oração; 2. Cuidado prestado através da atenção às necessidades espirituais e da garantia de conforto. Considerações finais: Embora de forma empírica e não consciente do cuidado espiritual prestado, a equipe de enfermagem oferta apoio com palavras de otimismo, fé, momentos de orações e contribui para o conforto espiritual da pessoa em paliação.

Skin-to-skin contact and breastfeeding at childbirth: women's desires, expectations, and experiences / Contato pele a pele e amamentação no momento do parto: desejos, expectativas e experiências de mulheres

ABSTRACT Objective: To analyze women's desires, expectations and experiences regarding skin-to-skin contact and breastfeeding in the first hour of life of their newborns. Methods: Qualitative research carried out in a teaching hospital in the Northeast Region of Brazil. The patients were followed longitudinally during prenatal care, at birth and during the puerperium. The participants were pregnant women during normal risk prenatal care, aged over 18 years old. Structured and semi-structured interviews were carried out in the prenatal period, participant observation at the time of delivery and new interviews in the puerperium. Content analysis was applied in the thematic modality. Results: 18 women between 21 and 38 years old were enrolled in the research. Women expressed the desire for skin-to-skin contact and breastfeeding as immediate practices right after delivery and birth. However, many women did not believe it was possible, and the performance of routine procedures was considered the main obstacle. These expectations that skin-to-skin contact and early breastfeeding would not be carried out were confirmed in the experiences immediately after birth. Conclusions: The expectations and experiences brought by these women suggest a flaw that starts in prenatal care and implies difficulties in implementing the studied practices. Thus, the empowerment and participation of women can become an important tool in the humanization of birth.

RESUMO Objetivo: Analisar os desejos, as expectativas e as experiências de mulheres no que diz respeito ao contato pele a pele e à amamentação na primeira hora de vida. Métodos: Pesquisa qualitativa realizada em um hospital de ensino de uma capital da Região Nordeste. As mulheres foram acompanhadas longitudinalmente, durante o pré-natal, o parto e o puerpério. As participantes eram gestantes em pré-natal de risco habitual, com idade maior de 18 anos. Foram realizadas entrevistas estruturadas e semiestruturadas no pré-natal, observação participante no momento do parto e novas entrevistas no puerpério. Fez-se a análise de conteúdo na modalidade temática. Resultados: Participaram da pesquisa 18 mulheres, entre 21 e 38 anos. Elas expressaram o desejo do contato pele a pele e da amamentação como práticas imediatas após o parto e o nascimento, contudo muitas não acreditavam que fosse possível, sendo o principal entrave a realização de procedimentos de rotina. As expectativas de impossibilidade do contato pele a pele e amamentação precoce foram confirmadas no momento do parto. Conclusões: As expectativas e experiências trazidas pelas mulheres apontam para uma falha que se inicia no pré-natal e implica dificuldades na implementação das práticas estudadas. Desse modo, o fortalecimento da participação das mulheres pode se mostrar uma ferramenta importante na humanização do nascimento.

Immune response of adult horses, pregnant mares and foals to an experimental vaccine with recombinant EMA-2 protein of Theileria equi.

Equine theileriosis, caused by the Theileria equi protozoan, is a disease of worldwide importance. T. equi expresses surface proteins, of which the EMA-2 protein is a promising antigen for vaccine use. The aim of this study was to evaluate the immune response of adult horses, pregnant mares, and foals to an experimental EMA-2 protein of recombinant T. equi vaccine. A total of 46 horses were used in this study for vaccine trials and challenges. Twelve geldings, 14 pregnant mares, and 14 foals were divided into vaccinated and control groups. Total serum specific anti-rEMA-2 IgG, IgG subclasses, and transcription of cytokines related to the immune response were evaluated. For the vaccine challenge, six six-month-old foals were divided into vaccinated and control groups. For the challenge, blood from a horse with theileriosis was transfused to the foals. Geldings and pregnant mares maintained anti-rEMA-2 IgG levels at 130 and 140 days after vaccination, respectively. The most-detected IgG subclasses in vaccinated were IgG3/5, IgG4/7, and IgG1. IL2, IL10, IL12, IL17, IFN-γ, and TNF-α were the most-transcribed cytokines in PBMCs of vaccinated horses stimulated with rEMA-2. Challenge with T. equi demonstrated that vaccinated foals had an increase of 33% in total IgG four days after blood transfusion, while control foals had no significant response, suggesting that vaccine antibodies may have recognized EMA-2 protein of the native T. equi antigen. T. equi recombinant EMA-2 was shown to be a promising vaccine antigen by inducing humoral and cellular immunity similar to that observed in natural parasite infections.

SKIN-TO-SKIN CONTACT AND BREASTFEEDING AT CHILDBIRTH: WOMEN'S DESIRES, EXPECTATIONS, AND EXPERIENCES.

OBJECTIVE: To analyze women's desires, expectations and experiences regarding skin-to-skin contact and breastfeeding in the first hour of life of their newborns. METHODS: Qualitative research carried out in a teaching hospital in the Northeast Region of Brazil. The patients were followed longitudinally during prenatal care, at birth and during the puerperium. The participants were pregnant women during normal risk prenatal care, aged over 18 years old. Structured and semi-structured interviews were carried out in the prenatal period, participant observation at the time of delivery and new interviews in the puerperium. Content analysis was applied in the thematic modality. RESULTS: 18 women between 21 and 38 years old were enrolled in the research. Women expressed the desire for skin-to-skin contact and breastfeeding as immediate practices right after delivery and birth. However, many women did not believe it was possible, and the performance of routine procedures was considered the main obstacle. These expectations that skin-to-skin contact and early breastfeeding would not be carried out were confirmed in the experiences immediately after birth. CONCLUSIONS: The expectations and experiences brought by these women suggest a flaw that starts in prenatal care and implies difficulties in implementing the studied practices. Thus, the empowerment and participation of women can become an important tool in the humanization of birth.

Coping strategy for covid-19 in primary health care: experience report in Salvador-BA.

OBJECTIVE: To report the experience of actions to confront the Coronavirus developed by primary health care in the municipality of Salvador, Bahia, Brazil. METHODS: It is an account of the experience carried out by a nurse from the health management of the city of Salvador, in the fight against the Coronavirus, without a period from February 26 to April 26, 2020. RESULTS: A flow of action was elaborated to confront the Coronavirus in the primary health care network, aiming to implement conducts in the face of the pandemic. The professionals were trained to identify suspected cases of contamination and to guide or refer these people to the health service. CONCLUSION: It was concluded that the construction of a flow to attend suspected cases of contamination by Coronavirus was relevant to mitigate the impacts, protecting the community and professionals involved.

Metal Bioaccumulation by the Neotropical Clam Anomalocardia flexuosa to Estimate the Quality of Estuarine Sediments.

This investigation evaluated the bioaccumulation potential of the tropical estuarine bivalve Anomalocardia flexuosa for trace metals. To this aim, chemical and sedimentological analyses and bioaccumulation tests were performed. The sediments were mainly composed by fine-sands and mud, with variable levels of organic matter and CaCO3. Muddy sediments from a depositional site (P2) presented the highest concentrations of metals, despite SEM/AVS not indicating bioavailability. Bioaccumulation factors showed high ratios for Cd, Ni, and Zn, while associations between the contents of mud, organic matter, CaCO3 and metals in sediments and tissues of A. flexuosa were indicated by a principal component analysis. The SEM/AVS was not effective to predict the bioavailability through dissolved metals. The results showed that contaminants were bioavailable, while the performed bioaccumulation test proved to be a reliable technique for assessing sediment contamination in estuarine regions. Moreover, A. flexuosa was considered an adequate test organism for bioaccumulation studies.