RESUMO
Four meroterpenoids (3a, 3b, 4 and 5), a prenylated pyran-2-one (2) along with the known compounds 7-O-geranylscopoletin (1), and thapsitranstagin (6) have been isolated from the roots of Thapsia transtagana. The presence of 1 and 2 supports the biogenetic hypothesis that transtaganolides, a group of bioactive metabolites, are meroterpenoids which come from an O-prenylated coumarin via successive pericyclic reactions.
Assuntos
Produtos Biológicos/biossíntese , Piranos/isolamento & purificação , Terpenos/isolamento & purificação , Thapsia/química , Espectroscopia de Ressonância Magnética , Piranos/metabolismo , Espectrometria de Massas por Ionização por Electrospray , Terpenos/metabolismoRESUMO
Five phenylpropanoids have been isolated from the roots of Thapsia transtagana. Their structures have been elucidated by spectroscopic means.
Assuntos
Apiaceae/química , Propanóis/química , Propanóis/isolamento & purificação , Estrutura Molecular , Marrocos , Raízes de Plantas/químicaRESUMO
Four novel and unusual C-19 compounds from Thapsia transtagana, named transtaganolides A-D, have been isolated. Their structures were established by physical methods, including X-ray analysis of transtaganolides A and B. This is the first time that a 7-methoxy-4,5-dihydro-3H-oxepin-2-one ring has been found in a natural product. [structure: see text]