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1.
J Oleo Sci ; 59(12): 653-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21099143

RESUMO

While screening for antioxidative carotenoids from marine bacteria, we isolated and identified sarcinaxanthin and its glucosylated compounds (sarcinaxanthin monoglucoside and sarcinaxanthin diglucoside) from a moderately halophilic bacterium-Micrococcus yunnanensis strain AOY-1. In the singlet oxygen ((¹O2) quenching model, the IC(50) values of the antioxidative activities of these carotenoids were as follows: sarcinaxanthin , 57 µM; sarcinaxanthin monoglucoside, 54 µM; and sarcinaxanthin diglucoside, 74 µM. In addition, the complete proton nuclear magnetic resonance (¹H NMR) assignments of sarcinaxanthin monoglucoside pentaacetate and sarcinaxanthin diglucoside octaacetate, and fast atom bombardment mass spectrometry/mass spectrometry (FAB-MS/MS) analyses of sarcinaxanthin and sarcinaxanthin monoglucoside are reported for the first time.


Assuntos
Antioxidantes/química , Antioxidantes/farmacologia , Carotenoides/química , Carotenoides/farmacologia , Micrococcus/química , Glucosídeos/química , Glucosídeos/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Conformação Molecular , Prótons , Oxigênio Singlete/química , Estereoisomerismo , Xantofilas/química , Xantofilas/farmacologia
2.
J Antibiot (Tokyo) ; 63(6): 291-5, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20414323

RESUMO

We performed the chemical mutagenesis of Halobacillus halophilus (the producer of a C(30) carotenoid, methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate) to isolate novel carotenoids that are biosynthetic intermediates of methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate. As a result, we isolated two novel C(30) carotenoids, hydroxy-3,4-dehydro-apo-8'-lycopene and methyl hydroxy-3,4-dehydro-apo-8'-lycopenoate, which were biosynthesized through a novel 8'-apo C(30) pathway. These carotenoids showed antioxidative activity in the (1)O(2) suppression model.


Assuntos
Antioxidantes/isolamento & purificação , Bacillaceae/metabolismo , Carotenoides/isolamento & purificação , Antioxidantes/farmacologia , Carotenoides/farmacologia , Relação Dose-Resposta a Droga , Licopeno , Mutagênese , Ressonância Magnética Nuclear Biomolecular , Oxirredução/efeitos dos fármacos
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