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Exp Diabetes Res ; 2011: 173647, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21318139

RESUMO

Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.


Assuntos
Glicemia/metabolismo , Metabolismo dos Lipídeos/efeitos dos fármacos , Malpighiaceae , Extratos Vegetais/farmacologia , Efeitos Tardios da Exposição Pré-Natal/metabolismo , Animais , Bebidas , Glicemia/efeitos dos fármacos , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/patologia , Feminino , Masculino , Malpighiaceae/química , Fenômenos Fisiológicos da Nutrição Materna/efeitos dos fármacos , Metaboloma/efeitos dos fármacos , Gravidez , Gravidez em Diabéticas/patologia , Ratos , Ratos Wistar , Estreptozocina
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