RESUMO
The drug sensitivity of seven Trypanosoma vivax-isolates from Kenya and Somalia was examined. With the exception of diminazene aceturate all commercially available trypanocidal drugs failed to effect a cure. The results suggest the existence of multiple drug resistance of T. vivax-strains, geographically widely distributed along the East African Coast. The isolates were resistant to the recommended dose rates of isometamidium, homidium and quinapyramine. Isometamidium showed no prophylactic properties when tested against one of the isolates. All were sensitive to diminazene aceturate.
Assuntos
Tripanossomicidas/farmacologia , Trypanosoma/efeitos dos fármacos , Animais , Bovinos , Diminazena/análogos & derivados , Diminazena/farmacologia , Resistência a Medicamentos , Etídio/farmacologia , Quênia , Masculino , Fenantridinas/farmacologia , Compostos de Quinolínio/farmacologia , Somália , Tripanossomíase Africana/tratamento farmacológico , Tripanossomíase Bovina/tratamento farmacológicoRESUMO
Autochthonous dogs from Liberia/West Africa were reared trypanosome-free and brought to West Berlin/germany. Together with Beagle dogs they were infected cyclically by tsetseflies with Trypanosoma congolense. While the European dogs died soon of the trypanosomal infection, the African dogs developed milder parasitaemias and remained clinically unaffected. The authors' opinion is, that this dog model could make a contribution to research on trypanotolerance.
