[Mechanisms of formation of chronic low back pain relapse and their correction in patients with dorsopathy].

A clinical-neurological, psychological, biochemical and electromyographic study of 40 operated and 40 non-operated patients with chronic low back pain syndrome was conducted before and after treatment. The authors used various modes of administration of xydifonum, a chelate from the group of bisphosphonates, including electrophoretic, peroral and administration in the form of ointment, administered in turn with heparin one to improve the antiplatelet effect, using photopheresis the with the help of the state-of-the art photomatrix LED equipment. The application of Ca2+-modulating properties of xydifonum demonstrate its universality in achieving of analgesic, muscle-relaxing, anxiolytic and antidepressant effects thus allowing to exclude polypragmasy. This is a main difference between this drug and other medications with limited effects. Based on the results obtained, the authors propose a scheme of development of chronic low back pain.

[Pathogenetic validation of xidiphone use in combined therapy for periodontal diseases]. / Patogeneticheskoe obosnovanie primeneniia ksidifona v kompleksnoi terapii boleznei parodonta.

It is well grounded for the application of a preparation from group bisphosphonates xydiphone is justified (reasonable). For treatment and preventive maintenance of a tooth stone for want of periodontal inflammation. Is shown on 30 patients with acute parodontitis and at 10--with gingivitis (in a stage of a peaking), that the application of xydiphone will neutralize an alkaline response having a place up to treatment, due to what it(he) exhibits antiseptic of a property. Xydiphone, linking ionized Ca and free Fe, simultaneously hinders with activation of free--radical oxidation, reduces blood-flux and blocks process of crystallization.

[A pain syndrome of compression-reflex origin: the mechanisms of its development and the means for its therapeutic management]. / Bolevoi sindrom kompressionno-reflektornogo geneza: mekhanizmy razvitiia i puti terapevticheskogo vozdeistviia.

Complex observation and treatment of 112 patients with compressive-reflex syndromes of cervical osteochondrosis with pain as the leading clinical manifestation resulted in elaboration of the scheme of its pathogenesis. The main links of pathological process development as well as their relationships were described. The main means and methods of the correction of algesic syndrome development were determined on the basis of both own investigations and literary data. The peculiarity of this study was the inclusion of Xydiphone (the Russian-made drug from complexons group) in pathogenetic therapy. Its positive medical effect in treatment of the disease described was established.

[Experience in introducing monitoring computer systems in anesthesiology and intensive care units]. / Opyt vnedreniia monitorno-komp'iuternoi sistemy v praktiku raboty otdeleniia anesteziologii i reanimatsii.

The paper describes the author's experience in practically using a monitoring computer system at the Anesthesiology, Resuscitation and Intensive Care Unit, Republican Clinical Hospital No.1, in Izhevsky Udmurtia. The system enables physicians, primarily anesthesiologists-reanimatologists to automate their work. It also allows the problem of routine accounting and report documentation to be solved.

[Angioneurotic edema of the face and upper extremities]. / Neirovaskuliarnye oteki litsa i verkhnykh konechnostei.

A classification scheme in which the etiology, localization, course and intensity of edemas are reflected has been elaborated on the basis of examining 255 patients with neurovascular edemas of the face and upper limbs. The authors provide a list of the main diagnostic methods, which enables the mechanisms of the development of neurovascular edemas to be specified.

[Dynamics of neurological manifestations of occlusive diseases of the branches of the aortic arch in nonspecific aortoarteritis]. / Dinamika nevrologicheskikh proiavlenii okkliuziruiushchikh porazhenii vetvei dugi aorty pri nespetsificheskom aortoarteriite.

A retrospective analysis was made of complaints and focal neurological symptoms in patients with nonspecific aortoarteritis of brachiocephalic vessels. It is demonstrated that the latter ones appear at the early stages of the development of stenosis of the main vessels. This allows early elaboration of indications for angiologic examination of patients. It has been noted that surgical correction of the blood flow in aortic arch branches in the early phases of the disease materially improves prognosis.

[The use of xidifon in the vertebral artery syndrome during exacerbation]. / Primenenie ksidifona pri sindrome pozvonochnoi arterii v period obostreniia.

To remove painful attacks in patients with the vertebral artery syndrome, use was made of xidiphon. The two methods of its administration were developed: application and electrophoretic. 27 patients in the stage of the disease exacerbation were examined and then treated. Vertebrobasilar vessels were examined over time by REG. A study was made of the content of macroelements and trace elements in the area of the impaired vessel, of the status of the bulbar conjunctival vessels using a "ShchL-2" lamp, and of the changes in the psychovolitional sphere and lipid peroxidation. A positive analgesic effect was attained in 25 patients, making it possible to eliminate or diminish to a considerable measure the doses of analgesics.

[Treatment of patients with trigeminal neuralgia by xidifon electrophoresis]. / Lechenie bol'nykh nevralgiei troinichnogo nerva élektroforezom preparata ksidifon.

Fifty-two patients with trigeminal neuralgia were treated by electrophoresis with a 2% solution of ksidifon. 23 patients demonstrated a remarkable analgetic effect in the form of disappearance of painful paroxysms and activity of the trigger zones, which enabled a considerable reduction of the daily dose of carbamazepine (finlepsin). In 14 patients, the rate and severity of algic attacks noticeably decreased without the lowering of the finlepsin dosage. Therefore, the suggested method of the treatment of trigeminal neuralgia, being simple in use, effectively removes the painful syndrome, contributing to a noticeable reduction of the doses of the toxic drugs of the carbamazepine type.

[Changes in rheological properties of blood in multiple sclerosis and their correction]. / Izmeneniia reologicheskikh svoistv krovi pri rasseiannom skleroze i ikh korrektsiia.

As many as 45 patients with multiple sclerosis were examined for rheological blood properties. As compared to controls, the group under examination manifested the rise of plasma viscosity, acceleration of red blood cell aggregation. 26.2% of patients demonstrated an appreciable increase of blood viscosity. It is assumed that these changes contribute to the deterioration of microcirculation and aggravate the demyelinating process. Correction of the rheological properties of the blood by plasmapheresis coupled with other methods of pathogenetic therapy turned out effective.

[Transcranial Doppler sonography combined with other ultrasonic methods in the diagnosis of stroke]. / Transkrania'lnaia dopplerosonografiia v sochetanii s drugimi u'ltrazvukovymi metodami v diagnostike insu'lta.

The use of transcranial Doppler sonography (TDS) in combined ultrasound diagnosis was the first to allow a noninvasive assessment of cerebral circulation. Altogether 50 patients in acute stroke period were examined. The results obtained were verified at surgery, cerebral angiography or autopsy. Changes in the velocity of the blood flow, its reversal, different Doppler sonogram pattern appeared controversial for cerebral and subarachnoid haemorrhages caused by the occlusion of the internal carotid artery or other factors of encephalomalacia. TDS employment promotes the improvement in the diagnosis of the cause underlying the acute impairment of cerebral circulation and in the prognosis of cerebral coma. The findings are correlated with routine echo-pulsography and Doppler sonography.

[Transcranial Doppler sonography in healthy persons]. / Transkranial'naia doplerosonografiia u zdorovykh liudei.

The authors describe the technical parameters and methodology of transcranial Doppler sonography as applied to studying the blood flow in vessels of the brain base. The results of the examination carried out in 25 healthy subjects have shown a high informative value of transcranial Doppler sonography in studying the circulation in the arterial and venous collectors. The new method is compared with the routine Doppler sonography and echopulsography.

[Role of disorders of the hemostatic system in the pathogenesis of multiple sclerosis and ways of correcting them]. / Rol' narushenii sistemy gemostaza v patogeneze rasseiannogo skleroza i puti ikh korrektsii.

The changes in the hemostatic system were studied in 77 patients with different patterns of disseminated sclerosis (DS). The studies demonstrated activation of both vasculothrombocytic and coagulation components of hemostasis as well as of fibrinolytic blood properties. The latent course of the disseminated intravascular coagulation was revealed in 20.7% of cases. The role of hemostatic disorders in the pathogenetic mechanisms of DS is discussed. The patients with DS received pathogenetic treatment including drugs eliminating hemostatic disorders, which was beneficial for most patients.

[Status of the hemostatic system in trigeminal neuralgia and facial pain of cervical origin]. / Sostoianie sistemy gemostaza pri trigeminal'noi nevralgii i litsevykh boliakh tservikal'nogo geneza.

An examination of patients with trigeminal neuralgia and facial pains of the cervical genesis (in cervical osteochondrosis, bone anomalies of the same localization, the syndrome of musculus scalenus anterior) revealed hemostatic impairments. These changes were generalized in trigeminal neuralgia and regional in the second group of patients, being particularly overt during a pain attack. The data obtained must be taken into account in evaluating the pathogenesis and in administering multiple modality therapy.

[Clinical picture and treatment of multiple sclerosis]. / K klinike i lecheniiu rasseiannogo skleroza.

The results of a long-term follow up of 41 patients with disseminated sclerosis are summarized. The significance of a careful clinical examination and prolonged observation over patients with opticomyelitis and disseminated encephalomyelitis as initial diagnoses is underlined: the appearance of new neurological disorders several years after the disease debut changed the diagnosis in favor of disseminated sclerosis. The drugs normalizing hemostatic function are offered for pathogenetic treatment of disseminated sclerosis. It is emphasized that patients given these drugs show a definite clinical improvement.

[Ultrasound tomography of extracranial vessels]. / Ul'trazvukovaia tomografiia ékstrakranial'nykh sosudov.

The paper deals with the potentialities of visualizing the carotid and temporal arteries as well as jugular veins with the help of the non-invasive method for compound real-time ultrasound scanning. In 18, out of twenty healthy volunteers examined, the echotomograms exhibited reasonably clear-cut images of the above-listed vessels. Their localization, size, and pulsation patterns are described, which enables one to differentiate the arterial and venous trunks. Visualization of the vertebral artery was also performed. The technique of ultrasound transducer orientation by means of Doppler sonography is presented.