[Experimental approach to the prophylaxis and treatment of acute lung injury syndrome with proteinase inhibitors and corvitin]. / Eksperymental'ni pidkhody do profilaktyky ta likuvannia syndromu hostroho ushkodzhennia lehen' z vykorystanniam inhibitoriv proteïnaz i korvitynu.

The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way.

[Changes in the local proteinase-inhibitor system in children with chronic erosive gastritis]. / Izmeneniia mestnogo proteinazno-ingibitornogo potentsiala u detei, bol'nykh khronicheskim érozivnym gastritom.

In 26 children presenting with chronic erosive gastritis, an unspecific proteinase-inhibitor potential was identified in the basal portion of the gastric juice in the period of exacerbation and incomplete remission. Revealed in the gastric content in the period of exacerbation was augmentation of the activity of elastase- and tripsinlike proteinases. In the period of remission, the indices have been shown to be lower but insignificantly, remaining significantly higher compared to those indices in the control group. There was a decrease in the antiproteinase potential in the period of exacerbation getting even more lowered during the period of incomplete remission. The findings secured suggest to us a manifest imbalance in the local proteinase-inhibitor system. A conclusion has been reached that exhaustion of the local inhibitor potential and ensuing high activity of unspecific proteinases result in destructive changes in the gastric mucosa, thus, having pathogenetic significance in the development of chronic inflammatory-and-destructive diseases.