Decreasing Sedentary Time during Lessons Reduces Obesity in Primary School Children: The Active Movement Study.

INTRODUCTION: School-based exercise interventions targeted at reducing obesity are often successful in the short term, but they are resource-heavy and do not always lead to long-lasting behaviour changes. This study investigated the effect of reducing sedentary time, rather than increasing exercise, on physical activity (PA) behaviours and obesity in primary school children. METHODS: Thirty UK state primary schools participated in this cluster-controlled intervention study (IDACI score = 0.15 ± 0.07, free school meals = 26 ± 9%). Twenty-six intervention and 4 control schools (intervention = 3,529, control = 308 children) completed the Physical Activity Questionnaire for Children (PAQ-C) in terms 1 and 3. Three intervention and 3 control schools (intervention = 219, control = 152 children) also measured waist-to-height ratio (WTHR). The Active Movement Intervention is a school-based programme which integrates non-sedentary behaviours such as standing and walking in the classroom. Data were analysed via ANCOVAs and multiple linear regressions. RESULTS: WTHR was reduced by 8% in the intervention group only (F(2, 285) = 11.387, p < 0.001), and sport participation increased by 10% in the intervention group only (F(1, 232) = 6.982, p = 0.008). Other PAQ-C measures increased significantly in the intervention group, but there was no group*time interaction. Changes in PAQ-C did not predict reductions in WTHR. Instead, the amount of change in WTHR was predicted by intervention group and by baseline WTHR of the pupil, where children with higher baseline WTHR showed greater reductions (F(2, 365) = 77.21, p < 0.001, R2 = 0.30). Socio-economic status (SES), age, or gender did not mediate any of the changes in the PAQ-C or WTHR. CONCLUSION: Reducing sedentary behaviours during school time can be an effective obesity reduction strategy for primary school children who are overweight. The lack of demographic effects suggests that this method can be effective regardless of the school's SES, pupil age, or gender.

Device-measured physical activity and sedentary behaviour in relation to mental wellbeing: An analysis of the 1970 British cohort study.

Although physical activity and sedentary behaviour have established associations with mental illness, the extent to which they impact on mental wellbeing is not well understood. We examined associations between moderate to vigorous physical activity (MVPA), sitting time (ST) and mental wellbeing in 4526 participants from the 1970 British Cohort Study (UK) in the age 46 survey (2016-18). MVPA and ST were measured using a thigh mounted accelerometer device (activPAL 3 micro) worn continuously for 7 days and participants completed the 14-item Warwick-Edinburg Mental Wellbeing Scale (WEMWBS) to assess mental wellbeing. In linear regression models MVPA (per hr) was associated with an additional 0.57 points on the WEMWBS (95% CI 0.03-1.12) regardless of gender, wear time, education, socioeconomic status, smoking, body mass index, disability and psychological distress. ST was not associated with WEMWBS in the adjusted models (B = -0.11, -0.23, 0.02). In MVPA stratified analyses, ST showed a linear trend with WEMBS in participants with low levels of MVPA but not in medium and high MVPA categories. In this large, nationally representative cohort, device-measured MVPA showed an association with higher mental wellbeing whilst ST was only associated with reduced mental wellbeing in participants with low levels of MVPA. Our main limitation was the cross-sectional design which precludes any inference of direction of association or causality. Nevertheless, interventions to promote MVPA may be an effective public health policy to promote mental wellbeing. Further investigation of the effect different sitting behaviours has on mental wellbeing is warranted.

Evaluation of the Omron HEM-907 automated blood pressure device: comparison with office and ambulatory blood pressure readings.

Blood pressure (BP) measured in the clinic is subject to the white coat effect and does not always indicate the 'usual' BP. Ambulatory BP is the current gold standard, but remains inconvenient for routine use. Interest in automated BP, where the healthcare professional is absent from the examination room during BP measurement, is growing, as this reduces the white coat effect and yields BP values that are close to ambulatory readings. The aim of this study was to investigate how well automated office BP (AOBP), measured using the Omron HEM-907 device, compares with observed office BP (OOBP, healthcare professional remains in the examination room) and awake ambulatory BP (AABP) measurements. OOBP, AOBP and AABP were measured in 108 participants, with OOBP and AOBP measurements repeated 1 week later, following a standardised protocol. Average BP readings for visit one were 134 ± 18/77 ± 11 for OOBP, 131 ± 16/75 ± 11 for AOBP, and 133 ± 15/82 ± 12 for AABP. On both visits, automated readings were significantly lower than observed readings for both systolic and diastolic BP (P < 0.001 for both). Automated readings were also significantly lower than ambulatory readings, with a mean difference in systolic/diastolic BP of - 2 ± 11/- 7 ± 10 (P < 0.001 for both), with high correlations between the two modalities (r = 0.75 and r = 0.64, for systolic and diastolic BP, respectively, P < 0.001 for both). AOBP measured by the Omron HEM-907 is not associated with a white coat effect, unlike observed readings, and provides reproducible results and good correlations with ambulatory readings. Automated BP measured using the Omron HEM-907 is, therefore, a useful alternative to observed office readings.

Bladder vs enteric drainage following pancreatic transplantation: How best to support graft survival? A best evidence topic.

A best evidence topic in transplant surgery was written according to a structured protocol. The question addressed was: In patients undergoing pancreatic transplantation alone, does enteric drainage or bladder drainage of exocrine secretions provide the best graft survival? A total of 155 papers were identified using the search protocol described, of which four retrospective cohort studies represented the best evidence available to answer the clinical question. The authors, journal, date and country of publication, study type, patient group studied, relevant outcomes and results of these papers are tabulated. Three of the four studies demonstrated no significant difference in graft survival between enteric drainage and bladder drainage at 6 months or 1 year. This included the largest and most recent study which showed that patient survival, graft survival and technical failure rates at 1 year were equal between the two duct management techniques. However, one study indicated lower graft survival at 1 year with enteric drainage due to a higher technical failure rate. Therefore, the clinical bottom line is that there is no significant difference in graft survival between enteric drainage or bladder drainage of pancreatic exocrine secretions for pancreas transplants alone. There is some evidence that enteric drainage may be associated with higher technical failure and higher graft rejection but this has not been universally demonstrated. Given the historical nature of all the available evidence, further appropriately powered and randomised Level 1 studies are necessary to clarify this important issue.