Assuntos
Amiodarona/efeitos adversos , Antiarrítmicos/efeitos adversos , Insuficiência Cardíaca/etiologia , Hipotireoidismo/induzido quimicamente , Derrame Pleural/diagnóstico por imagem , Idoso de 80 Anos ou mais , Feminino , Insuficiência Cardíaca/diagnóstico , Humanos , Hipotireoidismo/complicações , Derrame Pleural/etiologia , Radiografia , UltrassonografiaAssuntos
Infecções por Klebsiella/diagnóstico , Klebsiella pneumoniae , Sepse/diagnóstico , Tromboembolia/diagnóstico por imagem , Feminino , Febre/etiologia , Humanos , Infecções por Klebsiella/complicações , Pessoa de Meia-Idade , Radiografia , Sepse/complicações , Esplenomegalia/etiologia , Tromboembolia/complicações , Tromboembolia/microbiologiaRESUMO
OBJECTIVE: To analyze the characteristics of systemic necrotizing vasculitis observed in necropsy emphasizing the non-diagnosed cases until necropsy and to identify the reasons of clinical confusion. MATERIALS AND METHODS: Necropsies of adult patients performed in Hospital General La Paz, Madrid, from 1966 to 1977 were reviewed. Clinical manifestations, analytical changes and involvement of different organs were analyzed. The correspondence degree between clinical and necropsic diagnoses was studied. RESULTS: A total of 18 cases of necrotizing vasculitis were observed out of 3,980 necropsies. The most common clinical manifestations were fever and general syndrome (60%). The organs most commonly involved were kidney (94%) and gastrointestinal tract (56%). Diagnosis was revealed by necropsy in 39% of cases; in these cases, the incidence of heart failure and peripheral neuropathy was significantly lower, whereas digestive hemorrhage and liver, pancreas, adrenal gland, and bladder involvement was significantly higher. CONCLUSIONS: Systemic necrotizing vasculitis in underdiagnosed, which can be partly explained by the lack of specificity of the most common symptoms and the paucity of characteristic clinical and organ-specific manifestations which leads to confusion with more prevalent conditions.
Assuntos
Vasculite/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Autopsia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , NecroseRESUMO
A case of Hashimoto's thyroiditis associated with incomplete Sjögren's syndrome is revised. Both immune disorders are together not just as a casual event, but literature says that common mechanisms could have something to be. Previous publications express that autoimmune thyroid dysfunction is frequently associated with primary Sjögren's syndrome and should be sought clinically and by laboratory test in all these patients.
Assuntos
Doenças Autoimunes/diagnóstico , Síndrome de Sjogren/imunologia , Tireoidite Autoimune/imunologia , Adulto , Humanos , Masculino , Síndrome de Sjogren/diagnóstico , Síndrome , Tireoidite Autoimune/diagnósticoRESUMO
A fifty-four-years old male with palpable purpura, polyarthritis and nephritic syndrome is presented. The renal biopsy disclosed mesangial proliferation with IgA deposits. During hospitalization abdominal pain and upper digestive bleeding also presented. Digital angiography showed splenic artery microaneurysms. Then it's a new case of polyangiitis overlap with mixed features of Schönlein-Henoch purpura and polyarteritis nodosa. Differential diagnosis between several vasculitic associations in a patient is discussed.
Assuntos
Vasculite por IgA/diagnóstico , Poliarterite Nodosa/diagnóstico , Biópsia , Diagnóstico Diferencial , Glomerulonefrite por IGA/diagnóstico , Humanos , Rim/patologia , Masculino , Pessoa de Meia-Idade , SíndromeRESUMO
A prospective study of the capillaroscopy changes in 15 patients afflicted with vasculitis is presented. 2 of them had classic polyarteritis nodos (PAN), 3 had Churg-Strauss allergic angiitis and granulomatosis, 2 had hypersensitivity vasculitis (HV), 6 had giant-cell arteritis (GCA) and 2 had polyangiitis overlap syndrome (POS). Periungual capillaroscopy (PC) showed isolated changes in 11 patients (73%). We observed more changes in those cases with active disease (83% vs. 67%); they were mainly microhemorrhage (without any statistical significance). There were no more findings in patients with a more generalised affliction (nervous system, kidneys and/or skin) than in the others. In conclusion, the capillaroscopy findings were few and non-specific. PC is a diagnostic method of negligible value in this type of disease.
Assuntos
Unhas/irrigação sanguínea , Vasculite/patologia , Capilares/patologia , Feminino , Humanos , Masculino , Estudos ProspectivosRESUMO
The analysed clinico-biological manifestations, evolutive course and treatment of 30 patients with GCA are presented. The most frequent symptoms were fever and headache. 33% of patients had FOD criteria. 26% had various visual alterations. All patients were initially treated with steroids. Of the 26 patients followed up, 21 (81.7%) experienced some sort of complication: Cushing iatrogenic, osteoporosis, vertebrae collapse, aseptic necrosis of the femur head, arterial hypertension, diabetes mellitus, hyperlipidemia, steroid myopathy. 6 patients were treated with cyclophosphamide, following severe complications secondary to steroid therapy, and all of them had a good clinical evolution.