RESUMO
Polymorphism of GSTT1 and GSTM1 variant genes of phase II biotransformation of xenobiotics was studied in 181 patients with lung cancer. Null genotype frequency in cancer patients was higher than in healthy subjects. It was still higher in metastatic cancer disseminated to the regional lymph nodes as compared with localized tumor.
Assuntos
Biomarcadores Tumorais/genética , Glutationa Transferase/genética , Neoplasias Pulmonares/genética , Polimorfismo Genético , Idoso , Estudos de Casos e Controles , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
415 female residents of the City of Tomsk and Tomsk Region (patients with cervical carcinoma--22, dysplasia stage I-III--23 and healthy subjects--71) were screened for HPV16/18 infection, which was diagnosed in 18.3%. In the cervical carcinoma group, infection was detected in 27.4%, among patients with advanced cervical dysplasia--25.7%, and in those with background pathologies and healthy females--12.3 and 38%, respectively. Infection peaks were reported for the age brackets of 31-40 years (19.7%) and 51-60 years (19.6%). HPV-infection showed a wide range of colposcopic symptoms: areas of atypical blood vessels, leukoplakia, atypical epithelium and iodine-negative patches. Papillomavirus-related morphological changes in endometrial cells were typical of those associated with any viral infection and showed no specific features.
Assuntos
Colo do Útero/patologia , Colo do Útero/virologia , Papillomaviridae , Infecções por Papillomavirus/diagnóstico , Infecções Tumorais por Vírus/diagnóstico , Displasia do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Adolescente , Adulto , Idoso , Colposcopia , Feminino , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/virologia , Infecções Tumorais por Vírus/patologia , Infecções Tumorais por Vírus/virologia , Displasia do Colo do Útero/patologia , Displasia do Colo do Útero/virologia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologiaRESUMO
Specific immunological indices have been compared in patients with head and neck tumors. It was found that the EBV-specific antibody levels in such patients were almost one order of magnitude higher than similar indices in healthy humans. The study identified profound changes in the T-cell chain of the immune system which is responsible for intercellular interaction regulation and cell killing. Altered number of lymphocytes and proportion of their main regulatory subpopulations were founded in cancer patients.
