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1.
Artif Organs ; 2024 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-39404349

RESUMO

Apple AirPods Pro 2 recently received approval from the US Food and Drug Administration for use as an over-the-counter hearing aid device, the first approval of an over-the-counter hearing aid software by the Agency.

2.
Artif Organs ; 2024 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-39404594
3.
JTCVS Open ; 20: 112-122, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39296454

RESUMO

Objective: The pathway to cardiothoracic surgery is often obscure for premedical students and aspiring applicants and requires navigating various known and unknown obstacles. Recognizing the challenges encountered on the path to a career in cardiothoracic surgery in the United States, we present this guide for students interested in the field to maximize success in their premedical, preclinical, and preresidency years. Methods: This is a joint collaboration between the Thoracic Surgery Residents Association and the Thoracic Surgery Medical Student Association. Drawing from firsthand experiences and insights gathered from numerous student applicants and current surgical residents, a comprehensive guide was constructed for students from the point of undergraduate school to advanced training options, including super-fellowship training. Results: Several intricacies to cardiothoracic surgery career planning were discussed, including differences between traditional and integrated/fast-track pathways, college and medical school selection, networking, performing during clinical rotations, extracurricular and research activities, building mentorship relationships, and pursuing alternate career and advanced training opportunities. Conclusions: For premedical students and aspiring applicants, the road to cardiothoracic surgery requires meticulous planning, grit, and thoughtful dedication. This document consolidates firsthand insights and advice from numerous aspiring and matched applicants to serve as a comprehensive guide for students seeking a career in cardiovascular and thoracic surgery.

4.
Artif Organs ; 48(11): 1221-1222, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-39269152

RESUMO

Novel bioprinting technique offers strategy for building dense organ systems with complex multilayered vascular networks. Building on a technique called "sacrificial writing in functional tissue," researchers have developed immature organ systems capable of maintaining rudimentary function and maintaining viability owing to an intricate vascular network.


Assuntos
Bioimpressão , Impressão Tridimensional , Engenharia Tecidual , Humanos , Engenharia Tecidual/métodos , Bioimpressão/métodos , Prótese Vascular , Vasos Sanguíneos/fisiologia , Alicerces Teciduais/química
5.
Artif Organs ; 48(10): 1075-1076, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39120093

RESUMO

BiVACOR's Total Artificial Heart has been successfully implanted in a patient at Baylor St. Luke's Medical Center in the Texas Medical Center. The patient survived with the device for 8 days before receiving a heart transplant. This success stemmed from collaboration between BiVACOR Inc. and a team of cardiac surgeons at the Texas Heart Institute, including William E. Cohn, M.D., and Oscar H. Frazier, MD.


Assuntos
Coração Artificial , Humanos , Coração Artificial/história , Insuficiência Cardíaca/cirurgia , Masculino , Transplante de Coração/história , Transplante de Coração/métodos , Desenho de Prótese , Resultado do Tratamento , Pessoa de Meia-Idade , Implantação de Prótese/instrumentação , Implantação de Prótese/métodos
7.
Artif Organs ; 48(8): 805-806, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38924112

RESUMO

Transplantation has generally been focused on end-stage organ disease in adults. Scientists from Japan are now focusing on in utero transplantation in fetuses with congenital anomalies.


Assuntos
Transplante de Tecido Fetal , Humanos , Feminino , Gravidez , Anormalidades Congênitas/cirurgia , Feto/cirurgia , Doenças Fetais/cirurgia , Transplante de Órgãos/métodos
8.
Artif Organs ; 48(6): 575-576, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38646888

RESUMO

South Korean-based team is first to successfully transplant 3D bioprinted artificial trachea. The success arises during scrutiny of artificial tracheal implants stemming from the denounced work of Dr. Paolo Macchiarini.


Assuntos
Traqueia , Humanos , Traqueia/transplante , Traqueia/cirurgia , Impressão Tridimensional , Órgãos Artificiais , República da Coreia , Engenharia Tecidual/métodos , Bioimpressão/métodos
9.
Artif Organs ; 48(3): 208-209, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38102882

RESUMO

Bioartificial organ systems are becoming more attractive options for end-stage organ disease. Currently, end-stage liver disease has several palliative options but relies on transplantation for curative management. A new bioartificial liver has been approved for clinical trials in China and helps support the failed liver via stem cells.


Assuntos
Doença Hepática Terminal , Fígado Artificial , Humanos , China , Células-Tronco , Ensaios Clínicos como Assunto
10.
Artif Organs ; 47(11): 1683-1684, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37803947

RESUMO

Premature delivery is responsible for immense mortality and morbidity, partially owing to insufficient development of organs. Current supportive measures, like mechanical ventilation, are necessary to sustain life but have deleterious effects on the underdeveloped organs. A more physiological environment-the artificial womb-has been developed and is on the verge of approval for human clinical trials.


Assuntos
Nascimento Prematuro , Útero , Feminino , Humanos , Respiração Artificial
11.
Ann Thorac Surg ; 2023 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-37741565

RESUMO

BACKGROUND: We aimed to examine trends in the utilization and reimbursement of surgical and transcatheter mitral valve therapies and their changing relationship. METHODS: A query of administrative data on US Medicare beneficiaries undergoing mitral valve therapy was conducted from 2015 to 2020 using the Centers for Medicare and Medicaid Services Part B National Summary Data File. Inflation adjustment was to the 2020 Consumer Price Index. Trend analysis was quantified with growth rate and simple linear regression calculations. RESULTS: The annual number of all mitral valve procedures remained constant. Transcatheter mitral valve therapies increased by 313% with an increase of 1552 cases per year (P < .001), whereas surgical mitral valve therapies decreased by 31.4% with a decline of 1446 procedures per year (P = .004). As a proportion of all mitral valve therapies, surgical therapies decreased from 91.8% to 65.0%. Annual Medicare reimbursements for transcatheter and surgical mitral valve therapies mirrored the annual procedural trends. For transcatheter mitral valve therapies, per-case reimbursement decreased by 14.1% ($1283.18 to $1102.88), and for surgical mitral valve therapies, per-case reimbursement decreased by 3.8% ($1480.65 to $1424.57). CONCLUSIONS: Medicare utilization of mitral valve therapies has been stable in recent years, with growth of transcatheter volumes offset by a decrease in surgical volumes. This suggests that transcatheter therapy availability has not expanded the pool of patients with access to therapy. Nonetheless, case reimbursements decreased for both modalities.

12.
Artif Organs ; 47(9): 1421-1422, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37571816

RESUMO

Long-term donor organ preservation has been sought after since the beginning of transplantation. Static cold storage is the gold standard for organ transport but is limited to short-term preservation because of the inability to maintain subfreezing temperatures without harmful ice cyrstal formation. Recent developments in cryopreservation via vitrification and nanowarming have demonstrated reliable storage and restoration of healthy donor organs without ice crystallization.


Assuntos
Criopreservação , Gelo , Vitrificação , Preservação de Órgãos , Temperatura
13.
Ann Thorac Surg ; 116(4): 845-852, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37423345

RESUMO

BACKGROUND: Given the uncertainty of US health care finances, an understanding of reimbursement trends has become increasingly important in the field of cardiac surgery. We aimed to assess Medicare reimbursement trends for common cardiac surgical procedures from 2000 to 2022. METHODS: Reimbursement data were extracted from the Centers for Medicare and Medicaid Services Physician Fee Schedule Look-Up Tool during the study period for 6 common cardiac operations: aortic valve replacement, mitral valve repair and replacement, tricuspid valve replacement, Bentall procedure, and coronary artery bypass grafting. Reimbursement rates were adjusted for inflation to 2022 US dollars using the Consumer Price Index. Total percentage change and compound annual growth rate were calculated. A split-time analysis was performed to assess trends before and after 2015. Least squares and linear regressions were performed. The R2 value was calculated for each procedure, and slope was used to determine change in reimbursements over time. RESULTS: Inflation-adjusted reimbursement decreased by 34.1% during the study period. The overall compound annual growth rate was -1.8%. Reimbursement trends differed by procedure (P < .001), with all reimbursements trending down (R2 > 0.62), except for mitral valve replacement (P = .21) and tricuspid valve replacement (P = .43). Coronary artery bypass grafting decreased the most (-44.4%), followed by aortic valve replacement (-40.1%), mitral valve repair (-38.5%), mitral valve replacement (-29.8%), Bentall procedure (-28.5%), and tricuspid valve replacement (-25.3%). In split-time analysis, reimbursement rates did not significantly change from 2000 to 2015 (P = .24) but decreased significantly from 2016 to 2022 (P = .001). CONCLUSIONS: Medicare reimbursement significantly decreased for most cardiac surgical procedures. These trends justify further advocacy by The Society of Thoracic Surgeons to maintain access to quality cardiac surgical care.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Medicare , Idoso , Humanos , Estados Unidos , Valva Aórtica/cirurgia , Ponte de Artéria Coronária , Qualidade da Assistência à Saúde , Reembolso de Seguro de Saúde
14.
Artif Organs ; 47(7): 1073-1074, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37259906

RESUMO

Spurred by devoted research and institutional financing, organ replacement therapies have progressed monumentally over the last century. Concomitantly, there has been an escalation in healthcare costs. In an aging society where organ replacement therapy utilization is expected to continue to rise, will society need to rethink the economics of end-stage organ dysfunction management?


Assuntos
Órgãos Artificiais , Órgãos Artificiais/economia , Custos de Cuidados de Saúde
15.
Artif Organs ; 47(4): 615-616, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36861900

RESUMO

Synchron publishes SWITCH trial results demonstrating the safety and efficacy of stentrode™ device. The stentrode™ is an endovascularly implanted brain-computer interface communication device capable of relaying neural activity from the motor cortex of paralyzed patients. The platform has been used to recover speech.


Assuntos
Interfaces Cérebro-Computador , Córtex Motor , Humanos , Fala , Próteses e Implantes , Eletroencefalografia
16.
Artif Organs ; 47(2): 235-236, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36546615

RESUMO

Opioids are an effective remedy for pain control, but their detrimental side effects are prompting the development of less systemic and addictive options. A team from Pusan National University has developed an implant capable of precisely desensitizing peripheral nerves with temperature regulation. The device employs microfluidic technology.


Assuntos
Manejo da Dor , Nervos Periféricos , Humanos , Dor
17.
Artif Organs ; 46(12): 2341-2342, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36314368

RESUMO

Researchers from MIT have developed a chipless wireless electronic skin capable of detecting health information. They have improved upon the sensitivity, power efficiency, and long-term wearability of previous electronic skins. Continued development in this sector may soon make health tracking via electronic skin ubiquitous with the population.


Assuntos
Pele , Dispositivos Eletrônicos Vestíveis , Eletrônica
18.
Artif Organs ; 46(10): 1957-1958, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36039854
19.
Artif Organs ; 46(10): 1959-1960, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35997061

RESUMO

A team of Yale researchers demonstrated cellular and metabolic recovery with whole body perfusion after prolonged warm ischemia. This study reveals an underappreciated potential of cellular recovery and may lead to the expansion of suitable warm ischemic times.


Assuntos
Preservação de Órgãos , Isquemia Quente , Perfusão
20.
iScience ; 25(8): 104656, 2022 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-35847554

RESUMO

Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained to continue secreting cardioprotective growth factors/exosomes, and resist immunological host responses. Clinically relevant stem/progenitor cells in a rodent model of acute myocardial infarction (MI) demonstrated that neonatal cardiac mesenchymal stromal cells (nMSCs) provide the most robust cardiac functional recovery. Transplanted nMSCs significantly increased the number of tissue reparative macrophages and regulatory T-cells and decreased monocyte-derived inflammatory macrophages and neutrophils in the host myocardium. mRNA microarray and single-cell analyses combined with targeted depletion studies established CD47 in nMSCs as a key molecule responsible for cell retention in the myocardium through an antiphagocytic mechanism regulated by miR34a-5p. Gain and loss-of-function studies demonstrated that miR34a-5p also regulated the production of exosomes and cardioprotective paracrine factors in the nMSC secretome. In conclusion, miR34a-5p and CD47 play an important role in determining the composition of nMSCs' secretome and immune evasion, respectively.

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