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1.
J Health Organ Manag ; 38(6): 821-842, 2024 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-39198960

RESUMO

PURPOSE: The purpose of this research is to examine the relationship between high- performance work systems (HPWS) and organisational innovation in hospital settings, examining the role of employee engagement as a mediator in this relationship. Additionally, the study aims to investigate the moderating role of perspective-taking between HPWS and employee engagement as well as the moderating effect of trust in leader on the connection between employee engagement and organisational innovation. DESIGN/METHODOLOGY/APPROACH: A quantitative-deductive causal method, along with a cross-sectional approach, was utilized. Structural equation modelling was applied to analyse data from a sample of 530 doctors employed in hospitals, practicing human resources management in the public and private sectors of Sindh province, Pakistan. FINDINGS: The findings show positive effects of HPWS on employee engagement and organisational innovation. Additionally, employee's engagement partially mediates the relationship between HPWS and organisational innovation, while the moderating role of perspective-taking significantly influences the link between HPWS and employee engagement. ORIGINALITY/VALUE: While HPWS are recognized for enhancing organisational innovation, this study confirms their positive effects on individual and organisational outcomes, particularly within the healthcare sector in Pakistan. This study suggests that when HPWS are effectively perceived and implemented, these integrated practices can be beneficial for both employees and organizations, even in challenging situations.


Assuntos
Países em Desenvolvimento , Inovação Organizacional , Confiança , Engajamento no Trabalho , Paquistão , Humanos , Estudos Transversais , Masculino , Feminino , Adulto , Liderança , Inquéritos e Questionários
2.
Food Sci Biotechnol ; 32(9): 1281-1296, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37362809

RESUMO

Salicylic acid (SA) in different concentration were used to assess its individual effect as well as combined impact with 3% calcium chloride (CaCl2) on Swat No. 8 variety of peach stored at refrigerated temperature (6 ± 2 °C) for 21 days. Interestingly, the results revealed that applying 2 mmol L-1 SA with 3% CaCl2 maintained maximum nutritional value and least decay percent (44.1%) as compared to other treatments during storage. Moreover, this combination also exhibited significant weight loss and chilling injury at 6 ± 2 °C whereas increased levels of total phenolic, flavonoids, tannin, alkaloid, ascorbic acid, and antioxidant activity were observed as compared to other treatments. The combination treatment (2 mmol L-1 SA with 3% CaCl2) maintained other sensory attributes of peach fruit during refrigerated storage, therefore, its commercial use was recommended to store peach fruit for up to three weeks without any significant nutritional and physical loss.

3.
Cell Mol Biol (Noisy-le-grand) ; 67(1): 40-44, 2021 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-34817370

RESUMO

Propolis is a highly adhesive and resinous product of honey bee (Apis mellifera L.) which is produced from the exudations of plants. Bee propolis being a source of bioactive compounds like polyphenols and flavonoids imparts numerous biological properties including, antioxidant, anti-inflammatory, antimicrobial and anticancer activities. Present study was designed to elucidate the composition and antioxidant status of locally available propolis using in-vitro conditions. Propolis collected from locally found apiaries and its hydroalcoholic extract of propolis was prepared using different concentrations of ethanol and methanol. The results regarding proximate composition of propolis showed a higher proportion of ether extract (85.59±0.87%) and lowest contents of crude fiber (0.31±0.08%). Among the mineral's sodium, potassium and calcium was found in a concentration of 11.33±0.91, 52.10±2.9 and 10.53±0.83.59±0.23mg/Kg respectively whilst zinc was noticed as 3.59±0.23mg/Kg. HPLC characterization indicates a highest concentration of Chlorogenic acid 31.80±2.56mg/Kg whereas gallic acid (0.21±0.01mg/Kg) was found in lowest concentration among the polyphenols. Ethanol extract represents more phenolic contents, DPPH activity and antioxidant status as 327.30±14.89mg/gGAE, 73.18±4.43% and 60.59±4.38% accordingly in comparison to methanol and water extract. Bee propolis found an effective source of natural antioxidants which retards the production of free radicals and reactive oxygen species thus help to cope oxidative stress.


Assuntos
Antioxidantes/farmacologia , Abelhas/química , Cromatografia Líquida de Alta Pressão/métodos , Própole/análise , Própole/farmacologia , Animais , Anti-Infecciosos/análise , Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Antioxidantes/análise , Antioxidantes/química , Flavonoides/análise , Flavonoides/farmacologia , Sequestradores de Radicais Livres/análise , Sequestradores de Radicais Livres/química , Sequestradores de Radicais Livres/farmacologia , Estresse Oxidativo/efeitos dos fármacos , Paquistão , Fenóis/análise , Fenóis/farmacologia , Polifenóis/análise , Polifenóis/farmacologia , Própole/química
4.
Cell Mol Biol (Noisy-le-grand) ; 67(1): 32-39, 2021 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-34817371

RESUMO

Human diets with functional ingredients showed promising role in management of diseases of modern age like hyperglycemia and hyperlipidemia and even cancer. The study designed to elucidate role of honeybee propolis for management of hyperglycemia and hyperlipidemia states through animal modeling system. Hydroalcoholic extract of propolis was used for development of functional drink with standard recipe and addition of specified dose of extracts (400mg/500mL). Animals were grouped into three studies including study-I fed on regular diet, study-II fed on sucrose enrich diet and study-III fed on diet enriched with cholesterol and monitored to evaluate the results. Various parameters like feed consumption, liquid intake of animals measured regularly whereas body weight recorded at the end of each week of study. At the end of the study animals were analyzed for different blood indicators like blood lipid indices (cholesterol, LDL, HDL concentration and triglyceride contents)), glucose concentration and insulin contents as well. The maximum feed and drink intake were examined in animals, fed with control diet whereas a non substantial mode of intake was recorded in rest of two groups of animals. The consumption of honeybee propolis based drink reduced cholesterol (6.63% to 10.25%) and LDL (9.96% to 11.23%), whilst a sharp increase in HDL level was ranged as 4.12 to 4.49% among animal groups fed with high cholesterol and high sucrose diet. Blood glucose level was decreased by 10.25% and 6.98% however 6.99% and 4.51% increase were observed in plasma insulin level in both studies, study-II and study-III correspondingly. The overall findings of the study showed that drinks prepared using propolis of propolis found effective for management of hyperglycemia and hypercholesterolemia in present animal modelling system.


Assuntos
Modelos Animais de Doenças , Hiperglicemia/prevenção & controle , Hiperlipidemias/prevenção & controle , Própole/farmacologia , Animais , Anti-Infecciosos/farmacologia , Glicemia/metabolismo , Peso Corporal/efeitos dos fármacos , Colesterol/sangue , Humanos , Hiperglicemia/sangue , Hiperlipidemias/sangue , Insulina/sangue , Lipídeos/sangue , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Ratos Sprague-Dawley , Triglicerídeos/sangue
5.
Polish Journal of Environmental Studies ; 29(3): 2023-2030, 2020. tab, fig
Artigo em Inglês | LILACS, BVSDIP | ID: biblio-1560837

RESUMO

The main purpose of this study is to provide essential information regarding the molecular basis of insecticide resistance and to report candidate genes which are responsible for resistance in insects/pests. There are two basic resistance mechanisms existing in pests, i.e., target site resistance and metabolic resistance. During resistance of target site, the specific binding site of an insecticide is modified (mutated) and/or lost, which makes the target site incompatible for activation. Mutation occurs in most common pest (Myzus persicae, Musca domestica and Drosophila melanogaster) target regions, i.e., subunits like nicotinic acetylene choline receptors (nAChRs), knock-down resistance (KDR) etc. Due to these mutations, insecticides are unable to bind into the target region, resulting in loss of binding affinity. Furthermore, in metabolic resistance over production of enzymes occurs which break down (detoxify) insecticides and resulting resistance of pests. The amplification of metabolic enzymes, i.e., Cytochromes p450 monooxygenase, hydrolyses, and Glutathione S-transferase play a central role in evolving metabolic resistance. Various successful approaches are used to combat pests resistance such as insecticides, bio-pesticides and biological control agents. However, some of these strategies have certain limitations such as contamination of the environment, while others possess a low capacity in management of pests. Recent studies have highlighted some novel mechanisms of insecticide resistance that are part of the ongoing efforts to define the molecular basis of insecticide resistance in insect species.

6.
Artigo em Inglês | MEDLINE | ID: mdl-25290990

RESUMO

The aim of this study was to investigate the effects of calcium propionate, water activity (aw) and incubation time on the total fungal count and aflatoxins B1 (AFB1), B2 (AFB2), G1 (AFG1) and G2 (AFG2) production in the broiler finisher feed. The feed was added with calcium propionate (5 g kg(-1)), adjusted to 0.85, 0.90 and 0.95 aw and stored for 28 days at 25°C, analysing for mould growth and aflatoxins production every 7 days. Analysis of variance indicated that all the factors (preservative, aw and storage time) alone and in combination significantly (p < 0.001) affected the total fungal count and aflatoxins production in the feed. Minimum total fungal counts (1.99 × 10(2) CFU g(-1)) were observed in calcium propionate feed at 0.85 aw on day 1 and the highest (4.36 × 10(9) CFUs g(-1)) in control sample at 0.95 aw on day 28 of storage. During the storage period, AFB1 content in control samples increased from 11.35 to 73.44, from 11.58 to 81.81 and from 11.54 to 102.68 ng g(-1), whereas in preserved feed the content of B1 increased from 11.47 to 37.83, from 11.54 to 49.07 and from 11.20 to 53.14 ng g(-1) at 0.85, 0.90 and 0.95 aw, respectively. Similar patterns were noted for AFB2, AFG1 and AFG2 contents. All the aflatoxins readily increased over storage time; however, the increase was much slower in preserved feed that contained a lower amount of available water. This study reveals that calcium propionate addition to poultry litter along with water activity amelioration is an effective tool for controlling mould incidence and aflatoxin production in poultry feed.


Assuntos
Aflatoxinas/análise , Ração Animal/microbiologia , Microbiologia de Alimentos , Fungos/crescimento & desenvolvimento , Propionatos/análise , Aflatoxinas/biossíntese , Animais , Contagem de Colônia Microbiana , Fungos/efeitos dos fármacos , Aves Domésticas , Água
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