The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy.

INTRODUCTION: MRI is preferred for brain tumor assessment, while CT is used for radiotherapy simulation. This study evaluated immobilization equipment's impact on CT-MRI registration accuracy and MR image quality in RT setup. METHODS: We included CT and MR images from 11 patients with high-grade glioma, all of whom were immobilized with a thermoplastic mask and headrest. T1- and T2-weighted MR images were acquired using an MR head coil in a diagnostic setup (DS) and a body matrix coil in RT setup. To assess MR image quality, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were considered in some dedicated regions of interest. We also evaluated the impact of immobilization equipment on CT-MRI rigid registration using line profile and external contour methods. RESULTS: The CNR and SNR reduction was in the RT setup of imaging. This was more evident in T1-weighted images than in T2-weighted ones. The SNR decreased by 14.91% and 12.09%, while CNR decreased by 25.12% and 20.15% in T1- and T2-weighted images, respectively. The immobilization equipment in the RT setup decreased the mean error in rigid registration by 1.02 mm. The external contour method yielded Dice similarity coefficients (DSC) of 0.84 and 0.92 for CT-DS MRI and CT-RT MRI registration, respectively. CONCLUSION: The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.

A case report of prostate cancer with leptomeningeal metastasis.

BACKGROUND: Prostate cancer is the most prevalent cancer in men. However, leptomeningeal involvement by prostate carcinoma is a rare event. CASE: Here, we report a 69-year-old patient with castration-resistant metastatic prostate cancer who presented with headache and ataxia. Brain MRI revealed a huge invasive interaxial mass at right occipital lobe with diffuse thickening and enhancement of meninges, the arachnoid, and the pia mater, and he was diagnosed with leptomeningeal carcinomatosis. The patient received whole brain radiotherapy. CONCLUSION: Despite the fact that brain and leptomeningeal metastases are not very common in patients with prostate cancer, signs and symptoms of nervous system disorders should be assessed carefully, and consideration of such unusual metastases must be considered.

Determination of dosimetric parameters for shielded 153Gd source in prostate cancer brachytherapy.

BACKGROUND: Interstitial rotating shield brachytherapy (I-RSBT) is a recently developed method for treatment of prostate cancer. In the present study TG-43 dosimetric parameters of a 153Gd source were obtained for use in I-RSBT. MATERIALS AND METHODS: A 153Gd source located inside a needle including a Pt shield and an aluminum window was simulated using MCNPX Monte Carlo code. Dosimetric parameters of this source model, including air kerma strength, dose rate constant, radial dose function and 2D anisotropy function, with and without the shields were calculated according to the TG-43 report. RESULTS: The air kerma strength was found to be 6.71 U for the non-shielded source with 1 GBq activity. This value was found to be 0.04 U and 6.19 U for the Pt shield and Al window cases, respectively. Dose rate constant for the non-shielded source was found to be 1.20 cGy/(hU). However, for a shielded source with Pt and aluminum window, dose rate constants were found to be 0.07 cGy/(hU) and 0.96 cGy/(hU), on the shielded and window sides, respectively. The values of radial dose function and anisotropy function were tabulated for these sources. Additionally, isodose curves were drawn for sources with and without shield, in order to evaluate the effect of shield on dose distribution. CONCLUSIONS: Existence of the Pt shield may greatly reduce the dose to organs at risk and normal tissues which are located toward the shielded side. The calculated air kerma strength, dose rate constant, radial dose function and 2D anisotropy function data for the 153Gd source for the non-shielded and the shielded sources can be used in the treatment planning system (TPS).