[Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]. / Deistvie likopina na lipoproteidy krovi u zhenshchin s sakharnym diabetom 2 tipa v postmenopauze.

Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.

[Effects of underwater massage douche on left ventricular diastolic function in patients with chronic cardiac failure and postinfarction cardiosclerosis]. / Vliianie podvodnogo dusha-massazha na diastolicheskuiu funktsiiu levogo zheludochka u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu i postinfarktnym kardiosklerozom.

78 patients with postmyocardial infarction cardiosclerosis and moderate chronic cardiac failure (NYHA functional class 0-2) were given standard medication (enalapril, aspirin, atenolol) and took underwater massage douche. The effects of the latter on diastolic dysfunction of the left ventricular myocardium were studied. The above hydrotherapy changed parameters of left ventricular diastolic filling in 64% of the examinees: in 40% these parameters improved, in 23%--deteriorated. Clinical and device criteria essential for hydrotherapy outcomes are described.

[Ramipril effects on 24 hour profile of blood pressure in patients with mild and moderate hypertension]. / Vliianie ramiprila na sutochnyi profil' arterial'nogo davleniia u bol'nykh miagkoi i umerennoi arterial'noi gipertoniei.

AIM: The study of the effects of the inhibitor of angiotensin converting enzyme ramipril (tritace) on the 24-h profile of blood pressure (BP) in patients with mild and moderate arterial hypertension. MATERIALS AND METHODS: Ramipril was given to 21 males aged 45-68 years with essential hypertension stage II (WHO criteria) with stable elevated diastolic blood pressure (95-114 mm Hg) in a single dose 2.5-10 mg/day. Captopril controls received 100 mg twice a day. BP was monitored using "SpaceLabs Medical" unit (model 90207, USA). RESULTS: Compared to placebo, ramipril lowered systolic and diastolic blood pressure both for the 24-h period and in the day time; captopril lowered only diastolic BP in the day time. Side effects of long-term application of ramipril occurred 2 times less frequently than in application of captopril. CONCLUSION: Long-term treatment with ramipril in the above regimen provides more effective control of BP than captopril in the above doses in patients with mild and moderate hypertension.

[The characteristics of the blood lipid transport system in the disabled with lost lower extremities]. / Osobennosti lipidnoi transportnoi sistemy krovi u invalidov s utrachennymi nizhnimi konechnostiami.

A comparative analysis of major blood lipoprotein values in 108 males aged 16-65 years with lower limbs amputations has shown a higher level of triglycerides (TG) and a reduced level of high density lipoprotein cholesterol (HDL C) in them than in control males with normal limbs. In the subgroup of patients who had undergone the amputation as a result of obliterative arterial disease, the TG level was the highest while HDL C the lowest; moreover, these values appeared to be the same as in the age-matched subgroup of patients with manifestations of atherosclerosis. In the subgroup of older men with posttraumatic lower limb amputations (aged 40-59 years) the TG and HDL C levels did not differ from the corresponding parameters in age-matched subgroup of healthy subjects, whereas young amputees (17-39 years) had the increased blood TG concentration and reduced level of HDL C and apolipoprotein AI. The conclusion is made: disability following limb amputation accompanied by restricted mobility, inadequate physical static efforts as well as by chronic psychological stress seem especially dangerous for young invalids because of associated lipoprotein profile changes which can be regarded as highly atherogenic.

[The relation of uric acid metabolism to transferase activity in patients with ischemic heart disease and hypertension]. / Sviaz' obmena mochevoi kisloty s aktivnost'iu transferaz u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu.

Blood plasma uric acid and urea content and aspartate aminotransferase activity were studied in 177 patients with ischemic heart disease and essential hypertension. It was established that the blood uric acid level did not depend essentially on the transamination processes in patients with ischemic heart disease but was closely connected with transamination processes and amino acid metabolism in patients with essential hypertension.

[The orthostatic test with arterial hypertension patients]. / Ortostaticheskaia proba u bol'nykh arterial'noi gipertoniei.

The initial level of the systolic and diastolic arterial pressure (AP) effects the character and value of changes of these indices during the orthostatic test. With elevation of the initial AP level both the healthy and patients with arterial hypertension (AH) showed a tendency to a more pronounced reduction of the systolic AP and to a lesser increase of the diastolic AP in the orthostatic position. In-equal initial AP, patients with AH did not reveal any characteristic differences as compared with the healthy in the response of the AP to orthostasis.

[Experience in using echocardiography at a district diagnostic center]. / Opyt ispol'zovaniia ékhokardiografii v usloviiakh raionnogo diagnosticheskogo tsentra.

The authors studied the data of echocardiography performed at the district diagnostic center rendering services for 337000 adult population. Altogether 487 patients were referred to the center for echocardiography. The main portion of the patients included 398 persons (81.7%) with suspected heart disease and prolapse of one of the cusps of the mitral valve. 326 persons (66.7%) were under 39 years. The experience in the use of echocardiography under the conditions of the specialized polyclinics (the diagnostic center) has shown the high efficacy of the technique during examination of the patients at the prehospital stage.

[The role of homeostatic function of the kidneys in the development of hyperuricemia]. / Rol' gomeostaticheskoi funktsii pochek v razvitii giperurikemii.

The content of uric acid in blood plasma has been determined and its relation with the homeostatic renal function has been studied in CHD and hypertensive patients. The attenuation of renal filtration processes has been revealed in a half of the 117 patients. The CHD patients have showed a significant relation between the levels of uric acid and protein in blood. There is an immediate correlation between the uric acid content and alpha 2-globulins in patients with CHD and hyperuricemia. It has been suggested that the development of hyperuricemia in CHD patients is dut to the mechanism of disturbances in binding of uric acid to transport blood proteins.

[Possibilities of the use of echocardiography in epidemiologic examinations]. / Vozmozhnosti ispol'zovaniia ekhokardiografii pri épidemiologicheskikh issledovaniiakh.

The obtained experience of echocardiography use in wide population examinations demonstrate that it is of practical value for diagnosis of lesions of heart valves or other heart structures (about 10% of pathology in grown-up population). The efficacy of the method could be highly increased (from 37% to 81%) if the investigation was performed in patients with murmurs above the heart area, with cardiovascular diseases in anamnesis and with marked ECG alterations. Children and adolescents exhibited mainly various types of mitral valve prolapse.

[Effect of physical exertion on the changes in arterial blood pressure, heart rate and electrocardiogram in orthostatic position]. / Vliianie fizicheskoi nagruzki na izmeneniia arterial'nogo davleniia, chastoty serdechnykh sokrashchenii i elektrokardiogrammy v ortostaticheskom polozhenii.

Variations in arterial systolic (APs) and diastolic (APd) pressure, heart rate (HR) and electrocardiograms (ECG) were investigated in 22 normal men, 28 patients with arterial hypertension and 10 patients with chronic ischemic heart disease. Measurements were made during active orthostatic tests applied before and after submaximal exercises. In all three groups, APs diminished after exercise to a greater extent than before exercise. In hypertensive patients, APd increased significantly after exercise but changed insignificantly before exercise. In hypertensive patients with depressed T and ST, the level of ECG changes after exercise diminished by more than 50% as compared to the pre-exercise value.