Impact of Acute Short-term Hypobaric Hypoxia on Anterior Chamber Geometry.

PRCIS: Hypobaric hypoxia, the major environmental factor at high altitudes, has been observed to induce pupil miosis and widening of the anterior chamber angle. This environment may be safe for individuals with narrow angle and deserves further study. PURPOSE: This study aimed to quantify anterior chamber biometric parameters before and after acute short-term, effortless exposure to hypobaric hypoxia (HH) in healthy lowlanders using swept-source anterior segment optical coherence tomography (SS AS-OCT). METHODS: This prospective study included 25 healthy young lowlanders (50 eyes) who underwent SS AS-OCT measurements and intraocular pressure (IOP) assessments under baseline sea-level conditions (T1).They were then passively exposed to simulated 4000 m above sea level for 3 hours and underwent Acute mountain sickness (AMS) symptoms evaluation and IOP measurement after 2-hours exposure to HH (T2).Repeat SS AS-OCT measurements and IOP assessments were taken within 15 minutes after leaving the hypobaric chamber (T3). Anterior segment parameters including anterior chamber depth (ACD),lens vault (LV),angle opening distance (AOD500), trabecular-iris space area (TISA500), angle recess area (ARA500) at 500 µm from the scleral spur, iris curvature (IC), iris volume (IV), pupil diameter (PD), and central corneal thickness (CCT) were obtained through SS AS-OCT. These repeated measurements were compared using linear mixed model analysis. RESULTS: In comparison to sea level, both IOP (16.4±3.4 vs. 14.9±2.4 mm Hg, P=0.029) and PD (5.36±0.77 vs. 4.78±0.89 mm, P=0.001) significantly decreased after exposure to HH. Significant post-HH changes (Mean difference (95% CI)) were observed in AOD500 (0.129 (0.006, 0.252), P=0.04), TISA500 (0.059 (0.008, 0.11), P=0.025), ARA500 (0.074 (0.008, 0.141), P=0.029), IV (1.623 (0.092, 3.154), P=0.038), and IC (-0.073 (-0.146, 0.001), P=0.047), while CCT, ACD, and LV remained stable. After adjusting for age, post-HH variations in AOD500 (Beta=0.553, 95% CI: 0.001, 1.105, P=0.048) and TISA500 (Beta=0.256, 95% CI: 0.02, 0.492, P=0.034) were associated with decreased IC but were not related to lowered arterial oxygen pressure or IV increase per millimeter of pupil miosis (IV/PD). These differences in anterior segment parameters were neither correlated with differences in IOP nor AMS. CONCLUSION: After short-term, effortless exposure to hypobaric hypoxia, pupil miosis occurred with widening of the anterior chamber angle and decreased IC. These changes in anterior chamber angle parameters were associated with decreased IC but did not correlate with the post-hypobaric variations in IV/PD, IOP, or AMS.

Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.

The elevation in the optic nerve sheath (ONS) pressure (ONSP) due to microgravity-induced headward fluid shift is the primary hypothesized contributor to SANS. This longitudinal study aims to quantify the axial plane of the optic nerve subarachnoid space area (ONSSA), which is filled with cerebrospinal fluid (CSF) and expands with elevated ONSP during and after head-down tilt (HDT) bed rest (BR). 36 healthy male volunteers (72 eyes) underwent a 90-day strict 6° HDT BR. Without obtaining the pre-HDT data, measurements were performed on days 30, 60, and 90 during HDT and at 6 recovery time points extended to 180-days (R + 180) in a supine position. Portable B-scan ultrasound was performed using the 12 MHz linear array probe binocularly. The measurements of the ONS and the calculation of the ONSSA were performed with ImageJ 1.51 analysis software by two experienced observers in a masked manner. Compared to R + 180, the ONSSA on HDT30, HDT60, and HDT90 exhibited a consistently significant distention of 0.44 mm2 (95% CI: 0.13 to 0.76 mm2, P = 0.001), 0.45 mm2 (95% CI: 0.15 to 0.75 mm2, P = 0.001), and 0.46 mm2 (95% CI: 0.15 to 0.76 mm2, P < 0.001), respectively, and recovered immediately after HDT on R + 2. Such small changes in the ONSSA were below the lateral resolution limit of ultrasound (0.4 mm) and may not be clinically relevant, possibly due to ONS hysteresis causing persistent ONS distension. Future research can explore advanced quantitative portable ultrasound-based techniques and establish comparisons containing the pre-HDT measurements to deepen our understanding of SANS.

Analysis of critical land degradation and development processes and their driving mechanism in the Heihe River Basin.

In arid regions, land development and degradation (LDD) is sustained by the undesirable land development, human production and living, and climate change. Therefore, the understanding of LDD processes and their driving mechanism in the arid or semi-arid regions is significant to guarantee the sustainable development of ecological environment. This study explored the critical LDD processes in the Heihe River Basin (HRB) during 1990-2010 with the spatio-temporal evaluation of critical land use dynamics and its land quality changing trends. Then, the driving mechanism of cultivated land development process, grassland degradation process and water resource change process were analyzed by a simultaneous equations model which took the interaction of three processes into account. The results showed that the mutual transfers of cultivated land were primarily gathered in the middle reaches from 1990 to 2010. Its area grew by 13.5% and the average dynamic degree remained at 0.61%. The transfers between grassland and cultivated land, unused land were more remarkable, which led to the decline of grassland quality and even grassland degradation. Water area maintained a dynamic balance with almost unchanged area, but its dynamic trend was initially increasing and then decreasing. However, the average degradation of land quality in the whole study area is continuously alleviated. These changes were mainly due to the interaction of the LDD processes above, as well as socio-economic and climate change. Among them，agricultural research investments could restrain the unordered expansion of cultivated land resource for a relatively short period of time. Meanwhile, the variable of whether it is the main grain producing county is the main driver of grassland and water resource degradation in this region. These conclusions will provide scientific references for ecological land restoration and land quality improvement in the HRB.

Ecological environment assessment based on land use simulation: A case study in the Heihe River Basin.

Ecological environment assessment can not only provide significant references for effective solutions to regional ecological problems, but also promote the benign interaction of socio-economic-ecological development. This study selected the Heihe River Basin (HRB) as the typical area to comprehensively evaluate the ecological environment from 2010 to 2030 based on the dynamics of land system (DLS) model, which is coupled with the biological abundance index (BAI), vegetation coverage index (VCI), water density index (WDI), land degradation index (LDI), and eco-environment quality index (EQI). The results indicate that the BAI and VCI will be high in the south and east, low in the north and west in general. Under the future baseline scenario, the changes of biological abundance, vegetation coverage, and deteriorating land in the midstream and downstream regions will may seriously hinder restoration of the ecological environment. In particular, the BAI in the midstream and downstream regions will decline more rapidly, with a rate of 10.30% and 18.59%, respectively. The water area will be scattered and less abundant overall, but the WDI in the midstream, that is up to 3.86 in 2030, will be higher than that in other regions. Results also show that the regions with high EQI are mainly located in the northeast and south region. It is predicted that the ecological fragile zones in the future will mainly distribute in the midstream and downstream regions, especially in Jiayuguan City and Jinta County. The EQI will drop by 44.28% and 11.40% during 2010-2030 without external conditions intervened. In addition, Qilian Mountain, Jiuquan City, Gaotai County, Linze County, and Shandan County will also have relatively strong recovery capacities under the influence of ecological policies. All above could provide the basis for the development of future watershed ecological environment management and protection planning.

A novel torsion testing technique for micro-scale specimens based on electromagnetism.

A novel torsion apparatus for micro-scale specimens is developed based on electromagnetism, in which a coil-magnet component is used for actuating and torque measuring. When the current gets through the coil, the torque, produced by Ampere force, can be easily measured by recording the current. A laser displacement sensor is applied to measure the rotation angle. The torque is calibrated using Sartorius BP211D balance. The calibration results demonstrate there is a perfect linear relationship between the torque and the current. The torque capacity is 4.0 × 10(-4) N m with noise-floor of less than 10(-8) N m. The rotation angle capacity is 60° with noise-floor of less than 0.02°. Two sets of copper wire specimens, with diameter of 100 µm and 140 µm, are tested using this apparatus. Experimental results, with good resolution and repeatability, successfully demonstrate the effectiveness of the torsion testing technique for micro-scale specimens.