The Supports Intensity Scale Children's Version-Icelandic Translation: Examining Measurement Properties.

An innovation in developing the Supports Intensity Scale-Children's Version (SIS-C) was the adoption of latent variable modeling approaches to norm development. In regard to translated versions of the SIS-C, the latent modeling approaches provided opportunities to leverage the large standardization sample generated in the United States (n = 4,015) to generate translation-specific norms from data collected on smaller samples in other countries and enable future cross-cultural analyses. In this study, data were collected on children in Iceland who received special education services (as defined and delivered in Iceland), a more diverse group of children with disabilities than the U.S. sample. This provided a unique context to explore cross-cultural differences. Findings indicated the structure of the SIS-C (i.e., seven support need domains organized under an overall support needs construct), was supported in the Icelandic context. However, findings also suggested that supports planning teams in Iceland must consider specific age-related factors that differ from other cultural contexts.

The Assessment of Self-Determination in Spanish and American Adolescents: The Self-Determination Inventory: Student Report.

The purpose of this study was to explore the cross-cultural validity of the Self-Determination Inventory: Student Report, a newly developed measure of self-determination grounded in Causal Agency Theory. The tool was translated to Spanish and administered to American and Spanish adolescents. The sample was structured to include adolescents with and without intellectual disability in both cultural contexts. More than 3,000 students in the U.S. and Spain aged 13 to 22 completed the assessment. Findings suggest that the same set of items can be used across cultural contexts and in youth with and without intellectual disability, although there are some specific differences in item functioning across students with and without intellectual disability in Spain that must be further researched. There were specific patterns of differences in latent self-determination means, with students with intellectual disability scoring lower in the U.S. and Spain. Implications for assessment research and practice in diverse cultural contexts are explored.

Examining the Impact of Respondent-Level Factors on Scores on the Supports Intensity Scale - Children's Version.

This secondary analysis examined the impact of respondent-level factors on scores on the Supports Intensity Scale-Children's Version (SIS-C) for children and youth with intellectual disability to determine if there were any significant differences in the SIS-C scores by different respondent pairs when considering children's age, intellectual functioning level, and adaptive behavior level. Results indicated whenever a pair of respondents included a teacher or a paraprofessional, the support needs scores were lower than when the pair included a family member. Moreover, there was a significant interaction effect across respondent pairing, child age, and child intellectual functioning levels as well as across respondent pairing, child age, and child adaptive behavior levels. Implications for administration and use of the SIS-C are provided.

Health-Related Quality of Life of Older Adults in Costa Rica as Measured by the Short-Form-36 Health Survey.

Objective: To test the validity of a common measure of health-related quality of life (Short-Form-36 [SF-36]) in cognitively healthy older adults living in rural and urban Costa Rica. Method: Confirmatory factor analysis was applied to SF-36 data collected in 250 older adults from San Jose and Guanacaste, Costa Rica. Results: The best fitting model for the SF-36 was an eight first-order factor structure. A high correlation between the Mental Component Summary and Physical Component Summary scores was found. Region differences indicated that rural dwellers perceive a poorer health-related quality of life compared with the urban group. Discussion: Costa Rican older adults perceived health as a unidimensional construct. Age and urbanity of older adult Costa Ricans should be appreciated when trying to measure self-reported physical and mental health. Cultural context of the individuals should be considered when studying health-related quality of life.

Detecting Changes in Support Needs Over Time.

Assessment of support needs has received significant attention in the disability field, however, little is known about the stability of support needs scores over time. Data from 82 adults with intellectual and developmental disabilities (IDD) who were reassessed with the Supports Intensity Scale-Adult (SIS-A) version as well as the SIS-A Annual Review Protocol (SIS-A ARP) were analyzed. The findings suggest stability of SIS-A scores over a one- to three-year period in adults with IDD. Several sections of the SIS-A ARP showed discriminative power, particularly sections that asked if there had been changes in a subset of specific life activities assessed on the SIS-A and in medical and behavioral needs. Implications for further research and practice are discussed.

Assessing Character Strengths in Youth With Intellectual Disability: Reliability and Factorial Validity of the VIA-Youth.

This article reports the results of an examination of the endorsement, reliability, and factorial validity of the VIA-Youth and assessment of character strengths and virtues developed for the general population in youth with and without intellectual disability. Findings suggest that, generally, youth with intellectual disability endorsed character strengths as being like them at lower levels, although few differences were significant. Issues related to measurement, particularly the establishment of measurement invariance, emerged for some virtues. Reliability of the scale was similar across the two groups. Implications for future research and practice are discussed.

Examining Measurement Invariance and Differences in Age Cohorts on the Supports Intensity Scale-Children's Version-Catalan Translation.

Data from 949 children and adolescents with intellectual disability ages 5 to 16 for whom the Supports Intensity Scale-Children's Version-Catalan Translation was completed was used, in combination with data from the U.S. standardization sample, to examine measurement invariance and latent differences in the Catalonian sample. Results suggest that the same set of items can be used to measure support needs across U.S. and Catalonia samples and that there are age-related differences in support needs in the Catalonia sample, particularly between children ages 5 to 10 and 11 to 16 years of age. This differs from findings with the U.S. sample, where differences were found in a greater number of age cohorts. Implications for future research and practice are discussed.

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease.

OBJECTIVES: To assess the neurobiological substrate of initial cognitive decline in Parkinson's disease (PD) to inform patient management, clinical trial design, and development of treatments. METHODS: We longitudinally assessed, up to 3 years, 423 newly diagnosed patients with idiopathic PD, untreated at baseline, from 33 international movement disorder centers. Study outcomes were four determinations of cognitive impairment or decline, and biomarker predictors were baseline dopamine transporter (DAT) single photon emission computed tomography (SPECT) scan, structural magnetic resonance imaging (MRI; volume and thickness), diffusion tensor imaging (mean diffusivity and fractional anisotropy), cerebrospinal fluid (CSF; amyloid beta [Aß], tau and alpha synuclein), and 11 single nucleotide polymorphisms (SNPs) previously associated with PD cognition. Additionally, longitudinal structural MRI and DAT scan data were included. Univariate analyses were run initially, with false discovery rate = 0.2, to select biomarker variables for inclusion in multivariable longitudinal mixed-effect models. RESULTS: By year 3, cognitive impairment was diagnosed in 15-38% participants depending on the criteria applied. Biomarkers, some longitudinal, predicting cognitive impairment in multivariable models were: (1) dopamine deficiency (decreased caudate and putamen DAT availability); (2) diffuse, cortical decreased brain volume or thickness (frontal, temporal, parietal, and occipital lobe regions); (3) co-morbid Alzheimer's disease Aß amyloid pathology (lower CSF Aß 1-42); and (4) genes (COMT val/val and BDNF val/val genotypes). CONCLUSIONS: Cognitive impairment in PD increases in frequency 50-200% in the first several years of disease, and is independently predicted by biomarker changes related to nigrostriatal or cortical dopaminergic deficits, global atrophy due to possible widespread effects of neurodegenerative disease, co-morbid Alzheimer's disease plaque pathology, and genetic factors.

The Support Needs of Children with Intellectual Disability and Autism: Implications for Supports Planning and Subgroup Classification.

The Supports Intensity Scale-Children's version (SIS-C) was developed to provide a standardized measure of support needs of children with intellectual disability. Over half of the norming sample had a secondary diagnosis of autism. Using this subset of the sample, we engaged in exploratory analysis to examine the degree to which latent clusters were present in the data, and after identifying these clusters, the degree to which they mapped on the SIS-C standard scores. A four latent class solution provided the best fit to the data. When mapped on SIS-C standard scores, specific patterns of differences were found in life activity domain scores and overall support needs scores. Implications for future research and practice are discussed.

Centers for independent living and secondary transition collaboration: characteristics for enhanced service delivery for adolescents in the United States.

INTRODUCTION: Research involving secondary transition practices indicates a growing implementation of interagency collaboration to maximize service delivery to support students transitioning from school to adult life. Centers for Independent Living (CILs) are often excluded from collaborative partnerships and denied the opportunity to contribute as a valued stakeholder in the transition process. METHOD: A total of 189 CIL professionals representing represented 38 states completed the online survey to (a) identify to what degree does the factor structure of Thompson's Collaboration Survey holds for CIL professionals and (b) explore what specific CIL professional and agency characteristics predict greater collaboration between CILs and local education agencies (LEAs). Additionally (c) researchers sought to determine the degrees to which greater self-reported collaboration predicts more frequent transition services provided to transition-age youth by CIL professionals. RESULTS: Results indicated that the factor structure proposed by Thompson was confirmed in a sample of CIL professionals. None of the agency or individual characteristics (i.e., number of high schools partnered with, number of students served, amount of training in transition services, and importance of collaboration between high schools and agencies for transition) predicted greater collaboration with LEAS. When analyzing the effects of degree of collaboration on the services provided, high ratings on three of the five collaborative dimensions predicted a higher likelihood of providing services to transition-age youth. CONCLUSION: This study suggests that more training and experience of CIL professionals does not necessarily lead to greater collaboration. Additionally, the findings suggest that collaborative team structure is more important than social capital collaborative dimensions in leading to frequent services from CILs to transition-age youth. Implications for rehabilitation Extant literature suggests that secondary transition collaborative partnerships are critical to ensure students with disabilities have smooth transitions to adult life environments; The literature base calls for greater involvement from Centers for Independent Living (CILs) with local education agencies to maximize the benefit of youth with disabilities; This study suggests that more training and experience of CIL professionals does not necessarily lead to greater collaboration; and Collaborative team structure (i.e., Governance and Administration) is more important than social capital collaborative dimensions (i.e., Trust & Mutuality) in leading to frequent services from CILs to transition-age youth.

Examining age-related differences in support needs on the Supports Intensity Scale-Children's Version-Spanish translation.

Background: Interest in the support needs of people with intellectual disability has directed attention to developing assessments to measure of the pattern and intensity of supports which people need to participate in valued life activities. Assessments of the support needs of children must account for the influence of age. Method: Four hundred fifty (450) Spanish children with intellectual disability (ages 5-16) were assessed with the SIS-C Spanish. To test for measurement invariance and latent differences, the SIS-C Spanish standardization sample was linked to the SIS-C English normative sample. Models developed during the norming process were used to investigate measurement equivalence across age groups, differences in latent means, and differences in latent variances and standard deviations. Results: Findings suggested that all items on the SIS-C Spanish could reliably be used to measure support needs of children ages 5-16. When exploring age-related differences at the latent level, however, data showed latent mean differences in support need domain scores across age cohorts. Conclusions: The same set of items can be used to measure support needs in children ages 5-16, but age-related influences must be considered in developing norms for the SIS-C Spanish as well as in planning supports for children.

Antecedentes: El interés en las necesidades de apoyo de las personas con discapacidad intelectual debe centrarse en la evaluación del patrón e intensidad de los apoyos requeridos para realizar las actividades diarias. Cuando se evalúan estas necesidades en niños, se debe considerar además la influencia de la edad. Método: Se evaluaron 450 personas con discapacidad intelectual (5-16 años) mediante la versión española de la SIS-C. La invarianza de medida y las diferencias latentes fueron analizadas relacionando la muestra española con la muestra normativa de la versión en inglés. Los modelos desarrollados para la creación de baremos se utilizaron para estudiar las equivalencias de medida en los distintos grupos de edad y las diferencias latentes de sus medias, varianzas y desviaciones típicas. Resultados: Los ítems de la versión española de la SIS-C son fiables para medir las necesidades de apoyo en personas de entre 5 y 16 años. A nivel latente, los datos mostraron diferencias en las medias de las puntuaciones de diferentes grupos de edad. Conclusiones: Pueden utilizarse los mismos ítems para medir las necesidades de apoyo de niños y adolescentes, pero debe considerarse la influencia de la edad tanto en la creación de baremos como en la planificación de apoyos.

Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion.

Integrin alpha6beta4 is linked to cancer cell motility and invasion in aggressive and metastatic cancer cells. In this study, we showed that expression of the beta4 integrin in MDA-MB-435 cancer cells (MDA-MB-435/beta4) leads to a dramatic increase in expression of a metastasis-promoting factor, S100A4, as determined by affymetrix gene chip microarray, quantitative real-time PCR, and Western blot analysis. Alternatively, knocking down beta4 integrin expression in MDA-MB-231 breast carcinoma cells by shRNA reduced the level of S100A4 expression. The mechanism by which alpha6beta4 enhances S100A4 expression involves Src, Akt, and NFAT. We have further shown that Y1494, a tyrosine residue of the ITIM motif in the cytoplasmic domain of the beta4 integrin subunit, is essential for alpha6beta4-dependent S100A4 expression. Reduction of S100A4 expression by shRNA blocked migration, invasion, and anchorage-independent growth of MDA-MB-435/beta4, SUM-159, and MDA-MB-231 cells. These studies define a novel mechanism by which integrin alpha6beta4 promotes cancer cell motility and invasion, and provides insight into how S100A4 expression is regulated in cancer cells.