RESUMO
Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037 genes, 49% of which have no predicted function. Roughly 250 tandem gene duplications were found in addition to large-scale duplications of about 0.5 and 4.5 Mb between chromosomes 2 and 1 and between chromosomes 2 and 4, respectively. Sequencing of nearly 2 Mb within the genetically defined centromere revealed a low density of recognizable genes, and a high density and diverse range of vestigial and presumably inactive mobile elements. More unexpected is what appears to be a recent insertion of a continuous stretch of 75% of the mitochondrial genome into chromosome 2.
Assuntos
Arabidopsis/genética , Mapeamento Cromossômico , DNA de Plantas , Genes de Plantas , Núcleo Celular/genética , Centrômero , Evolução Molecular , Duplicação Gênica , Genes de Plantas/fisiologia , Mitocôndrias/genética , Dados de Sequência Molecular , Proteínas de Plantas/genética , Proteínas de Plantas/fisiologia , Análise de Sequência de DNAAssuntos
Síndrome da Imunodeficiência Adquirida/prevenção & controle , Educação em Saúde/organização & administração , Conhecimentos, Atitudes e Prática em Saúde , Hospitais de Veteranos , Pessoas Mal Alojadas/educação , Veteranos/educação , Coleta de Dados , Feminino , Educação em Saúde/estatística & dados numéricos , Pessoas Mal Alojadas/estatística & dados numéricos , Humanos , Masculino , Desenvolvimento de Programas , Fatores de Risco , Texas , Veteranos/estatística & dados numéricosRESUMO
Efforts of agencies and schools of social work to encourage goals of research and professional writing among their staff and faculty have brought uneven results. A medical center and a graduate school of social work are in the process of implementing a joint research model which encourages practice based research and publication. This paper describes the beginning structures of the model and the questions addressed in the formative process.