Assuntos
Acromegalia , Diabetes Mellitus Tipo 2 , Inibidores do Transportador 2 de Sódio-Glicose , Simportadores , Humanos , Inibidores do Transportador 2 de Sódio-Glicose/uso terapêutico , Acromegalia/tratamento farmacológico , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes , Glucose , SódioRESUMO
AIMS: Right ventricular (RV) function has important prognostic and therapeutic implications. Assessment of RV function using echocardiography is challenging. The aim of this study was to evaluate a new parameter of RV function, right ventricular outflow tract systolic excursion (RVOT_SE). METHODS AND RESULTS: RVOT_SE was measured using M-Mode echocardiography from the parasternal short-axis view at the level of the aortic valve, and was defined as the systolic excursion of the RVOT anterior wall. RVOT_SE was measured in 50 patients (age 64 ± 18 years, 28 males) with normal RV function [RV fractional area change (FAC) ≥35% and tricuspid annular plane systolic excursion (TAPSE) ≥1.6 cm] and 40 patients (age 68 ± 12 years, 35 males) with reduced RV function (RV FAC <35% and TAPSE <1.6 cm). R.V FAC was 46 ± 7% in the normal RV group and 22 ± 5% in the reduced RV group (P < 0.0001). TAPSE was 2.2 ± 0.4 cm in the normal RV group and 1.0 ± 0.2 cm in the reduced RV group (P < 0.0001). RVOT_SE was 9.6 ± 1.5 mm in the normal RV group and 1.7 ± 1.1 mm in the reduced RV group (P < 0.0001). RVOT_SE <6 mm identified patients with reduced RV function with 100% sensitivity and 100% specificity. Survival at 1 year was 63% in patients with RVOT_SE <6 mm and 84% in patients with RVOT_SE ≥6 mm, P = 0.004. CONCLUSION: RVOT_SE is a novel, simple, and promising parameter for assessing RV function, and it is associated with poor survival.
Assuntos
Ecocardiografia , Contração Miocárdica , Miocárdio/patologia , Disfunção Ventricular Direita/diagnóstico por imagem , Obstrução do Fluxo Ventricular Externo/diagnóstico por imagem , Idoso , Distribuição de Qui-Quadrado , Feminino , Indicadores Básicos de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Sensibilidade e Especificidade , Disfunção Ventricular Direita/patologia , Obstrução do Fluxo Ventricular Externo/patologiaAssuntos
Próteses Valvulares Cardíacas/efeitos adversos , Heparina/efeitos adversos , Estenose da Valva Mitral/etiologia , Trombocitopenia/induzido quimicamente , Feminino , Humanos , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Implantação de Prótese/efeitos adversos , Implantação de Prótese/métodos , Trombose/tratamento farmacológico , Trombose/patologia , Tomografia Computadorizada por Raios XRESUMO
This study examined the relation between high-sensitivity C-reactive protein (CRP), exercise-induced myocardial ischemia, and exercise tolerance in 288 stable patients who underwent maximal treadmill stress testing. CRP was correlated with peak exercise workload, which was consistent with the long-term predictive value of peak workload and CRP for outcome events. There was no correlation of high-sensitivity CRP with stress-induced ischemia, which is consistent with a lack of correlation between CRP and the degree of chronic luminal coronary arterial narrowing.