Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder.

Background Major depressive disorder (MDD) is a complex bio-psycho-social syndrome that affects millions of individuals and is one of the leading causes of impaired quality of life (QOL). In addition to the symptoms of depression and low mood, many individuals with MDD also suffer from isolation without the sense of a supportive, surrounding community. Given the challenges of treating individuals with MDD, social isolation and a lack of communal connection, this randomized controlled trial was designed to determine the efficacy of a multimodal, online and community-based lifestyle intervention for improving depressive symptoms and QOL in individuals with a history of MDD. Materials and methods The study enrolled 71 female or male participants between the ages of 20 and 64 with a self-reported BMI between 18.4 and 34.9 kg/m2 and a history of MDD. Individuals were randomized to either participate in a 44-day multimodal, online, community-based lifestyle intervention or placed on a wait list where they would complete the intervention at a later date. The multimodal intervention involved a self-directed learning program where individuals were guided to make lifestyle changes including adopting a whole-foods diet, increasing movement, and adopting stress management and mindfulness practices. All participants completed the 36-Item Short Form Health Survey (SF-36), the Cleveland Clinic Center for Functional Medicine's Medical Symptoms Questionnaire (MSQ), and the Patient Health Questionnaire-9 (PHQ-9) before and after the online program to assess health-related QOL, overall symptom burden, and depressive symptom burden, respectively.  Results A total of 37 participants were randomized to participate in the multimodal intervention with 26 completing all three study questionnaires at both study time points; 34 participants were randomized to the wait list control group with 27 completing all three study questionnaires at both study time points. There were no clinically or statistically significant differences between the control group or the intervention group at baseline. The control group showed no clinically nor statistically significant changes in the MSQ, PHQ-9 or any of the eight subdomains of the SF-36 from the beginning to the end of the 10-week study period. When compared to the control group, the intervention group showed statistically and clinically significant improvements in median (M) scores of the SF-36 subdomains of vitality and mental health, and clinically but not statistically significant improvements in the subdomain of emotional role functioning. There were additional statistically and clinically significant improvements in the mean score of the MSQ and M scores of the PHQ-9 (treatment pre-intervention M = 10.5, inter-quartile range [IQR] = 14, to treatment post-intervention M = 5, IQR = 8.25; control pre-intervention M = 15, IQR = 8, to control post-intervention M = 13.5, IQR = 12.5). Conclusions  Our randomized controlled study provides evidence for the role of a multimodal, online and community-based lifestyle intervention to improve depressive symptoms, QOL, and total symptom burden in individuals with a history of MDD. Given the growing challenges of effectively supporting individuals suffering with MDD, it appears critical to further explore the utilization of novel, multimodal and self-directed lifestyle interventions.

Compliance with wrist-worn accelerometers in primiparous early postpartum women.

BACKGROUND: There are few studies that objectively assess physical activity using accelerometry in postpartum women and none that do so before 3 months postpartum. It is not known whether accelerometry can be successfully used in the early postpartum period and thus benefit studies designed to assess the health benefits and risks of early physical activity. Wear compliance may be substantially lower several weeks after childbirth, given the overwhelming nature of the early postpartum period, particularly for first time mothers. The aims of this study were to 1) describe the methods used to facilitate protocol compliance of wrist-worn accelerometry, 2) describe device usage and wear time in early postpartum primiparous women and 3) to place the compliance characteristics of early postpartum primiparous women in our study in context with that of other studies of postpartum women and standards published by large, physical activity surveillance studies. METHODS: Participants were primiparous women who were enrolled at 3rd trimester in a larger ongoing prospective cohort study, delivered vaginally, and lived in a 60 mile radius of the research site. The parent study was designed to evaluate the effects of early physical activity on pelvic floor health. Participants wore a wrist accelerometer (ActiGraph™ GT3XLink device) over two 7-day periods, 2-3 weeks and 5-6 weeks postpartum. We developed a protocol based on best practices to enhance compliance in this population. The Choi (2011) algorithm was used to determine wear time. RESULTS: Of all participants, 82.6% (166 of 201 eligible) and 70.1% (141 of 201 eligible) at 2-3 and 5-6 weeks, respectively, received and wore a functional device in the correct study time-frame for at least 7 days. Of participants that received a functional device, 94.3% (166/176) and 86.5% (141/163) wore the device for at least 7 days, with mean wear times of 1348.0 (135.8) minutes/day and 1313.5 (152) minutes/day, respectively. At 2-3 weeks, 96.1% and 90.4% met the NHANES and Whitehall II Study wear standards, respectively, while at 5-6 weeks, 93.9% and 84.1% did so. CONCLUSION: Despite challenges in conducting physical activity research in postpartum women, adherence to wrist-worn accelerometry is high with this protocol.