Patients' perspectives on video consultation for non-communicable diseases: a qualitative study in Singapore.

BACKGROUND: The COVID-19 pandemic increased the use of telemedicine in primary care services. Understanding patients' perspectives on telemedicine is pivotal for its wider adoption in managing non-communicable diseases (NCDs) in the community. AIM: To explore the views and concerns of patients who have yet to use video consultation (VC) for NCD management in Singapore. DESIGN & SETTING: This qualitative study was conducted in a primary care clinic in Singapore. METHOD: In total, 16 patients participated in individual in-depth interviews. The participants had type 2 diabetes mellitus and/or hypertension and/or hyperlipidaemia without prior VC experience. They were purposively enrolled in the polyclinic. Audited transcripts were independently coded by two investigators. Thematic analysis was performed to identify perspectives on telemedicine based on the health, information, and technology zones of the Health Information Technology Acceptance Model. RESULTS: The following three themes emerged: perceived benefits of VC utility; perceived barriers of VC adoption; and potential challenges of VC. Participants viewed VC as safe and convenient if they had stable NCD. They voiced concerns on possible suboptimal care owing to the absence of physical examination, network connectivity, and personal medical data security. Participants highlighted challenges of VC uptake such as digital health familiarity, availability of their own mobile and telemonitoring devices, and healthcare costs consideration. CONCLUSION: Addressing the concerns and challenges highlighted by non-VC users can help physicians and policymakers explore ways to scale up telemedicine in Singapore. A hybrid clinical care model comprising in-person visits and VC may be the way forward for NCD management.

Exploration of Landscape Lighting Design Based on Interactive Genetic Algorithm.

There are many problems in the practical application of landscape lighting design. In order to solve these problems more specifically, based on the relevant theories of interactive genetic algorithm, radial basis function and hesitation degree are introduced into genetic algorithm. Through the analysis and processing of the data to get the optimized interactive genetic algorithm, the algorithm can analyze and optimize the landscape lighting design. Based on this model, the lighting design can be predicted and analyzed, and the prediction result is relatively good. Relevant studies show that the interactive genetic algorithm can be divided into three typical change stages according to the different results of intensity calculation, of which the first stage mainly presents the trend of gradual decline. The fluctuation phenomenon is obvious in the second paragraph. The third paragraph shows a gradual increasing trend of change. The corresponding relationship between the two fitness functions is obvious. With the increase of experts in independent variables, the corresponding fitness values show a trend of gradual decline on the whole. Through the calculation and analysis of five different indicators of landscape lighting by using interactive genetic algorithm, it can be seen that electrification has a relatively small impact on landscape lighting. The results of intelligent and environmental protection calculation are relatively high, and the corresponding range of change is relatively large, which shows that these two indicators are very important for improving the lighting design level of landscape. Finally, the model is verified by comparing data and model curves. Interactive genetic algorithm is very important to improve the lighting design of landscape, and the optimization model can be widely used in other fields.

Oscillation-Induced Mixing Advances the Functionality of Liquid Marble Microreactors.

Droplet-based microreactors often uncover fascinating phenomena and exhibit diverse functionality, which make them applicable in various fields. Liquid marbles (LMs) are non-wetting droplets coated with particles, and these features highlight their potential as microreactors. However, sophisticated experimental designs are typically hindered because it is difficult to obtain sufficient substance mixing in these miniature, damage-prone, self-supporting liquid containers. Here, we demonstrate that subjecting LMs to vertical oscillations by audio signals represents a controllable approach that allows sufficient mixing with variable dynamic modes. The characteristics and key issues in LM oscillation are systematically explored. The effects of oscillation on application potential are examined. Under oscillation conditions, homogeneous mixing can be achieved within a few seconds in LMs consisting of either water or viscous liquids. Importantly, the structures of materials synthesized in LMs can be regulated by modulating the oscillation modes. The variable modes, flexible adjustability, high efficiency, and wide applicability of this oscillation method make it a verified manipulation strategy for advancing the functionality of LM microreactors.

Liquid Plasticine Integrated with Isoelectric Focusing for Miniaturized Protein Analysis.

Developing miniaturized and rapid protein analytical platforms is urgently needed for on-site protein analysis, which is important for disease diagnosis and monitoring. Liquid marbles (LMs), a kind of particle-coated droplets, as ideal microreactors have been used in various fields. However, their application as analytical platforms is limited due to the difficulty of pretreating complex samples in simple LMs. Herein, inspired by the microfluidic chip, we propose a strategy through fabricating fluid channels using deformable LM, termed liquid plasticine (LP), to achieve sample pretreatment function. Through combining isoelectric focusing (IEF) with an LP channel, an LP-IEF platform with simultaneous protein separation and concentration functions is realized. The pretreatment capability of the LP-IEF system for proteins in physiological samples is proven using standard proteins and human serum with the results of a clear separation, 10-fold concentration, and a resolution of 0.03 pH. Through cutting the LP after IEF to LMs and transiting isolated LMs containing target proteins for further downstream colorimetric and mass spectrometry measurements, the quantitative analysis of clinical microalbuminuria and identification of α-1-microglobulin/bikunin precursor in clinical diabetic urine samples are achieved. This work proposes a strategy to develop LMs/LPs as a multifunctional integrated analytical platform and the miniaturized LP-IEF device as a rapid protein analytical platform.

Liquid marbles from soot films.

Soot films are the most easily available superhydrophobic surfaces. However, their cohesive forces are very weak such that they have been considered not suitable for direct use. Here we show that the seemingly undesirable mechanical weakness is actually an important property which allows a soot film to work as a superhydrophobic platform and tool, producing liquid marbles with fascinating properties and performances. A soot film is weak enough to lose component carbon nanoparticles (CNPs) on contact with water, but can adhere to a substrate stably on overturning or shaking the substrate. On this basis, we demonstrate that a liquid marble consisting of a liquid core and a CNP shell can be obtained by either rolling or an imprinting process. In addition, it is found that large-volume liquid puddles are easy to produce and manipulate with soot films by arbitrary shaking and pouring operations, without worrying about particles flying off that would occur in conventional powder-based liquid puddle production. The multifunctionality of CNPs endows soot liquid marbles/puddles with great potential in light shielding, electrical conduction, etc. This study reveals a direct application of soot films' superhydrophobicity, provides an alternative route for liquid marble production, and highlights the concept of disadvantage reversion.

Mechanical robustness of monolayer nanoparticle-covered liquid marbles.

Powder-derived liquid marbles (LMs) are versatile nonwetting systems but are confronted with many limitations in application, as their surface particles are usually large and agglomerated. Recently, sol-gel film-derived LMs have come on the scene that are termed monolayer nanoparticle-covered (mNPc) LMs based on their unique characteristics, revealing great application potential but also generating many questions. Here, mechanical robustness, a very important yet to be addressed property, of mNPc LMs was systematically studied. Rolling, pendant contact, and compression experiments were designed using bare and coated glasses with water contact angles (WCAs) ranging from 23° to 157°. With rupture as a quality criteria, the mechanical robustness of mNPc LMs enhanced with the hydrophobicity of solid surfaces that exerted pressure on them, but maintained much weaker than typical powder LMs until the solid surface was superhydrophobic. In particular, when contacting hydrophilic surfaces of WCAs ≤53°, an mNPc LM did not have the capacity for nonwetting and ruptured immediately, even if the pressure approached zero. This was distinct from powder LMs and indicated that a particle shell as thin as ∼20 nm could not prevent intermolecular attractions between the internal liquid and external solid surface. An interface scenario consisting of solid surface microroughness was proposed to address this issue. On the other hand, mNPc LMs remained unruptured on superhydrophobic surfaces but presented degraded elasticity under extreme compression. Uncovering these properties could be of much help for developments of mNPc LMs and their counterparts, the mNPc liquid plasticines.

Rod-shaped liquid plasticine for gas diffusion detection.

A rod-shaped liquid plasticine was produced here, which was then shown to serve as a versatile gas detector based on a coloration mechanism. It not only indicated gas existence but also visually revealed the gas frontier positions, which allowed the calculation of diffusion speeds and gas concentrations. This study demonstrated the feasibility of multifunctional applications in a liquid plasticine using its shape and optical advantages.

A capillary rise method for studying the effective surface tension of monolayer nanoparticle-covered liquid marbles.

The liquid marble covered with a xerogel-derived nanoparticle monolayer is emerging as a simple and ideal physical model for fundamental study. In this work, the effective surface tension, γeff, of this kind of water marble was studied by employing an optimized capillary rise method. This method is distinctive as it can reveal γeff at a specific point rather than the average γeff over the entire marble. γeff at the maximum lateral diameter position was investigated with particle coverage varying from 100% to 10%, showing a quite slow increasing trend from ∼64 to 72 mN m-1. The delay in the evolution of the γeff was attributed to the slow decline in the areal particle density on the side area of the marble. For comparative purposes, the maximum height method was also employed to determine γeff. The results of the two methods supported the position that a liquid marble's γeff depended on very specific conditions including the measurement method and all marble parameters.