T-wave vector alternans detection based on Holter ECG recordings.

This paper proposes a new method for detecting T-wave alternans (TWA) based on 3-channel Holter ECG recordings. The current standard method, based on spectral analysis of each signal lead, enables low amplitude alternans detection at the microvolt level. However, the method requires a controlled test environment where the mean heart rate is artificially increased. T Proposed method aims at realizing the reliable alternans detection from 24 hour Holter recordings during normal daily activities. To achieve this, the method utilizes singular value decomposition (SVD) for highly sensitive differentiation of T-wave morphology in noisy recording conditions. We propose the name T-wave Vector Alternance (TWVA) for TWA detected by SVD in decomposed ECG signals. The method was applied to three normal subjects and two subjects with TWA, and it correctly detected the TWA.

An improved QT interval measurement based on singular value decomposition.

This paper proposes an improved method of automatic ECG QT interval measurement based on the singular value decomposition (SVD) of multiple lead ECG signals. SVD separates multiple lead ECG record into orthogonal signals. Major orthogonal signals associated with high singular values are selected first for subsequent analysis. Instantaneous norm of the major three orthogonal signals are used for estimating Q wave initiating time tQ. Two dimensional trajectory of the major orthogonal signals are utilized for T wave end time tTE estimation. The T wave trajectory stagnates at tTE. For the accurate tTE estimation, this stagnation of the trajectory is proposed to be detected by its change in tangential angle. The proposed method was applied to 17 ECG data from normal subjects, patients of long QT syndrome (LQTS) and left ventricular hypertrophy (LVH) to demonstrate its effectiveness. Good consistent agreement, mean relative error of 5.01%, between estimated QT intervals and those of manual measurement by an experienced cardiologist was achieved.