Assuntos
Acne Vulgar/tratamento farmacológico , Antibacterianos/administração & dosagem , Dermatoses Faciais/tratamento farmacológico , Minociclina/administração & dosagem , Administração Cutânea , Adolescente , Adulto , Antibacterianos/efeitos adversos , Método Duplo-Cego , Feminino , Humanos , Masculino , Minociclina/efeitos adversos , Estudos Prospectivos , Índice de Gravidade de Doença , Adulto JovemRESUMO
BACKGROUND: The ideal dermal filler should be nonpermanent but with a durable effect lasting between 1 and 2 years, which is not the case with the resorbable fillers that are currently available. Evolence30 is a new, porcine-derived collagen gel based on the Glymatrix cross-linking technology, which results in a more natural and longer-lasting collagen product. METHODS: In this first clinical trial of Evolence30 (30 mg/ml), the safety and efficacy of this new filler were tested and compared with those of Zyplast (bovine cross-linked) collagen, after treatment of nasolabial folds in 12 volunteers. Safety assessments included two hypersensitivity tests, physical examination of injections sites, punch biopsies for histopathology, adverse events, and blood sample analysis. The seven-grade, validated Modified Fitzpatrick Wrinkle Scale was used by three independent blinded assessors to evaluate efficacy. RESULTS: No treatment-related adverse events were reported. Only transient erythema was observed in both treated sides, and there were no abnormal laboratory findings. None of the sera contained immunoglobulin (Ig) M, IgA, or IgE antibodies against porcine collagen at any time during the study. Initially, Evolence30 and Zyplast improved wrinkle severity to a similar extent. However, in an average follow-up of 18 months, assessment by the blinded assessors showed that the treatment effect on the Evolence30-treated side was superior in 9 of the 11 participants who were treated (p = 0.022). CONCLUSIONS: Evolence30 is a new, porcine-derived collagen product based on the Glymatrix cross-linking technology that enables a safe and effective correction of the nasolabial folds. This correction lasts significantly longer than that with Zyplast.
Assuntos
Colágeno/administração & dosagem , Ácido Hialurônico/administração & dosagem , Rejuvenescimento , Envelhecimento da Pele/efeitos dos fármacos , Idoso , Colágeno/efeitos adversos , Método Duplo-Cego , Estética , Feminino , Seguimentos , Humanos , Ácido Hialurônico/efeitos adversos , Injeções Intradérmicas , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente , Probabilidade , Fatores de Risco , Estatísticas não Paramétricas , Resultado do TratamentoRESUMO
BACKGROUND: Verrucous carcinoma of the foot is a slow-growing tumor that is capable of causing vast local destruction. It is a rare tumor and is frequently misdiagnosed as a plantar wart. OBJECTIVE: To describe a patient with verrucous carcinoma of the foot treated by Mohs micrographic surgery and give a review of the literature. RESULTS: A 43-year-old male with plantar verrucous carcinoma was successfully treated with Mohs micrographic surgery. CONCLUSION: Early diagnosis of verrucous carcinoma of the foot and treatment with Mohs micrographic surgery may prevent amputation of the foot.
