1.
Org Lett
; 26(1): 142-147, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38109110
RESUMO
An unprecedented strategy for Rh-catalyzed C-H activation/CâC bond cleavage of enaminones is described for the construction of biologically interesting aza-spiro α-tetralones and benzo[e]isoindoles. This protocol provides diversely functionalized aza-spiro α-tetralones and benzo[e]isoindoles in good yields via a [4 + 2] annulation of the exomaleimides and maleimides. This strategy displays a good substrate scope, outstanding functional group tolerance, and excellent regioselectivity.