[Radioisotope study of portal blood flow in extrahepatic portal hypertension in children]. / Radioizotopnoe issledovanie portal'nogo krovotoka pri podpechenochnoi portal'noi gipertenzii u detei.

The volume of portal blood that goes through the liver in portal hypertension is unknown up today. The level of portal perfusion after distal splenorenal bypass creation is not known either. Radioisotope splenography and mesenteriocoportography have been used to measure this level. It was found that in half of children with EPH more that 50% of the splenic blood and 100% of the blood from the superior mesenteric vein passes through the liver. The creation of the distal splenorenal bypass provided the perfusion at the level between 32 and 100% from the starting point. 100% of portal blood will pass to lungs through the bypass after traditional bypass operations.

[The biological properties of Haemophilus influenza isolated from healthy children and from patients with acute and chronic respiratory diseases]. / Biologicheskie svoistva Haemophilus influenzae, vydelennykh ot zdorovykh detei i bol'nykh ostrymi i khronicheskimi respiratornymi zabolevaniiami.

The comparative study of the biological properties of H. influenzae strains isolated from healthy children and from patients with acute and chronic respiratory diseases has been made, taking into account the biochemical features (biotypes) and adhesive activity of these strains. Differences in various biotypes of H. influenzae strains isolated from patients with bronchopulmonary diseases and from healthy carriers have been established. H. influenzae strains isolated from various sources differ by their adhesive properties: strains isolated from patients with acute bronchopulmonary diseases have the highest adhesive activity, while strains isolated from healthy controls have the lowest adhesive activity. The data thus obtained indicate the possible dependence of the degree and duration of the colonization of the respiratory tract by H. influenzae on the biological properties of these microorganisms. The monitoring of the sensitivity of H. influenzae strains to antibiotics has demonstrated that these strains retain high sensitivity to ampicillin, chloramphenicol, gentamicin and exhibit a tendency towards an increase in resistance to penicillin and erythromycin.

[The indices of antipneumococcal immunity in children with chronic pneumonia]. / Pokazateli protivopnevmokokkovogo immuniteta u detei, bol'nykh khronicheskoi pnevmoniei.

In 76 children with chronic pneumonia the levels of serum antibodies to pneumococcal capsular polysaccharide antigens (serotypes 1, 3, 6B, 8, 9N, 15F, 23F), O-polysaccharide and pneumococcal protein somatic antigens were determined by ELISA techniques. The study showed that in sick children the content of antipneumococcal antibodies in the blood increased with age. No correlation between the content of total immunoglobulins and that of antipneumococcal antibodies in the blood of the patients was established, but a sharp decrease in the concentration of antibodies was registered in a child with hypoglobulinemia. No increase in the level of antibodies to pneumococcal antigens was observed in cases of the exacerbation of Pneumococcus-induced inflammatory process in the lungs.

[Streptococcus pneumoniae serotypes in children with chronic inflammatory diseases of the respiratory organs]. / Serotipy Streptococcus pneumoniae u detei, bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami organov dykhaniia.

During the 7-year period of observation (1982-1988) the serotypes of 276 pneumococcal strains isolated from children with chronic bronchopulmonary diseases were studied. Among the serotypes of pneumococci under study, serotypes 6, 19 and 15 held the leading place and included a half of all typed pneumococci. Dynamic observation on the serotype composition of pneumococci revealed periodic fluctuations in the occurrence of some types/groups. The regional analysis of different serotypes of pneumococci showed the common occurrence of serogroups 6 and 19, as well as some regional features in the circulation of serotypes 6, 10, 3 and rarely occurring serotypes. The study revealed that any new exacerbation of the chronic bronchopulmonary process is caused by pneumococci of some other serotype. Pneumococcal strains, resistant (3.4%) and sensitive (1.8%) to penicillin, were detected; most of them belonged to serogroup 19.