In vivo Raman spectroscopy for detection of oral neoplasia: a pilot clinical study.

We report a pilot study carried out to evaluate the applicability of in vivo Raman spectroscopy for differential diagnosis of malignant and potentially malignant lesions of human oral cavity in a clinical setting. The study involved 28 healthy volunteers and 171 patients having various lesions of oral cavity. The Raman spectra, measured from multiple sites of normal oral mucosa and of lesions belonging to three histopathological categories, viz. oral squamous cell carcinoma (OSCC), oral submucous fibrosis (OSMF) and leukoplakia (OLK), were subjected to a probability based multivariate statistical algorithm capable of direct multi-class classification. With respect to histology as the gold standard, the diagnostic algorithm was found to provide an accuracy of 85%, 89%, 85% and 82% in classifying the oral tissue spectra into the four tissue categories based on leave-one-subject-out cross validation. When employed for binary classification, the algorithm resulted in a sensitivity and specificity of 94% in discriminating normal from the rest of the abnormal spectra of OSCC, OSMF and OLK tissue sites pooled together.

Spontaneous bilateral fracture of the mandible: a case report and review of literature.

Several mechanisms have been described in the literature for mandibular fractures. However, it is to be noted that fracture of mandible can occur spontaneously, especially in elderly persons with atrophic edentulous mandible. It is important to rule out local and systemic factors that can be the possible causes for fractures in these cases. We describe a case of spontaneous fracture of the mandible in an elderly lady with a review on possible mechanisms that can result in such fractures.