Biopsychosocial sequelae and recovery trajectories from whiplash injury following a motor vehicle collision.

BACKGROUND CONTEXT: Five out of 10 injured in a motor vehicle collision (MVC) will develop persistent pain and disability. It is unclear if prolonged symptoms are related to peritraumatic pain/disability, psychological distress, muscle fat, lower extremity weakness. PURPOSE: To test if widespread muscle fat infiltration (MFI) was (1) unique to those with poor recovery, (2) present in the peritraumatic stage, (3) related to known risk factors. STUDY DESIGN/SETTING: A cohort study, single-center academic hospital. PATIENT SAMPLES: A total of 97 men and women (age 18-65) presenting to an urban academic emergency medicine department following MVC, but not requiring inpatient hospitalization. PRIMARY OUTCOME MEASURE: Neck disability at 12-months. METHODS: Participants underwent magnetic resonance imaging (MRI) to quantify neck and lower extremity MFI, completed questionnaires on pain/disability and psychological distress (< 1-week, 2-weeks, 3-, and 12-months) and underwent maximum volitional torque testing of their lower extremities (2-weeks, 3-, and 12-months). Percentage score on the Neck Disability Index at 12-months was used for a model of (1) Recovered (0%-8%), (2) Mild (10%-28%), and (3) Moderate/Severe (≥ 30%). This model was adjusted for BMI and age. RESULTS: Significant differences for neck MFI were revealed, with the Recovered group having significantly lower neck MFI than the Mild and Moderate/Severe groups at all time points. The Mild group had significantly more leg MFI at 12-months (p=.02) than the Recovered group. There were no other significant differences at any other time point. Lower extremity torques revealed no group differences. The Traumatic Injury Distress Scale (TIDS) and MFI of the neck at 1-week postinjury significantly predicted NDI score at 12-months. CONCLUSIONS: Higher neck MFI and distress may represent a risk factor though it is unclear whether this is a pre-existing phenotype or result of the trauma. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02157038.

Dynamic Response and Residual Helmet Liner Crush Using Cadaver Heads and Standard Headforms.

Biomechanical headforms are used for helmet certification testing and reconstructing helmeted head impacts; however, their biofidelity and direct applicability to human head and helmet responses remain unclear. Dynamic responses of cadaver heads and three headforms and residual foam liner deformations were compared during motorcycle helmet impacts. Instrumented, helmeted heads/headforms were dropped onto the forehead region against an instrumented flat anvil at 75, 150, and 195 J. Helmets were CT scanned to quantify maximum liner crush depth and crush volume. General linear models were used to quantify the effect of head type and impact energy on linear acceleration, head injury criterion (HIC), force, maximum liner crush depth, and liner crush volume and regression models were used to quantify the relationship between acceleration and both maximum crush depth and crush volume. The cadaver heads generated larger peak accelerations than all three headforms, larger HICs than the International Organization for Standardization (ISO), larger forces than the Hybrid III and ISO, larger maximum crush depth than the ISO, and larger crush volumes than the DOT. These significant differences between the cadaver heads and headforms need to be accounted for when attempting to estimate an impact exposure using a helmet's residual crush depth or volume.

Single-sided Nuclear Magnetic Resonance for condition monitoring of cross-linked polyethylene exposed to aggressive media.

The potential of single-sided Nuclear Magnetic Resonance (NMR) to monitor truly non-invasive changes in polymer materials during aging under aggressive media is for the first time evaluated. For this, the NMR method is used in combination with other condition monitoring methods including mechanical measurements, mass uptake, and differential scanning calorimetry. It is validated by studying for the first time the aging kinetics of silane cross-linked polyethylene (PEX) exposed to media used in oil and gas production and transportation, including aliphatic and aromatic hydrocarbons, sulphur solvents, and corrosion inhibitors in combination with CO2 and H2S. All investigated parameters changed, with the strongest effects detected for the NMR chain mobility and in the presence of hydrocarbons. Furthermore, a universal linear correlation curve could be established between the depression of the tensile strength and the chain mobility. This result represents a fundamental step towards establishing single-sided NMR as a new analytical tool for in situ condition monitoring of polyethylene working under sour conditions. The proposed approach can be easily extended to other polymer materials.

Mechanical evidence of cervical facet capsule injury during whiplash: a cadaveric study using combined shear, compression, and extension loading.

STUDY DESIGN: A comparison of cervical facet capsule strain fields in cadaveric motion segments exposed to whiplash-like loads and failure loads. OBJECTIVES: To compare the maximum principal strain in the facet capsular ligament under combined shear, bending, and compressive loads with those required to injure the ligament. SUMMARY OF BACKGROUND DATA: The cervical facet capsular ligament is thought to be an anatomic site for whiplash injury, although the mechanism of its injury remains unclear. METHODS: Motion segments from seven female donors were exposed to quasi-static flexibility tests using posterior shear loads of 135 N applied to the superior vertebra under four compressive axial preloads up to 325 N. The right facet joint was then isolated and failed in posterior shear loading. The Lagrangian strain field in the right facet capsular ligament was calculated from capsular displacements determined by stereophotogrammetry. Statistical analyses examined the effect of axial compression on motion segment flexibility, and compared maximum principal capsular strain between the flexibility and failure tests. RESULTS: Capsular strain increased with applied shear load but did not vary with axial compressive load. The maximum principal strain reached during the flexibility tests was 61% +/- 33% of that observed in subcatastrophic failures of the isolated joints. Two specimens reached strains in their flexibility tests that were larger than their corresponding strains at subcatastrophic failure in the failure tests. CONCLUSIONS: The cervical facet capsular ligaments may be injured under whiplash-like loads of combined shear, bending, and compression. The results provide a mechanical basis for injury caused by whiplash loading.

Startle response of human neck muscles sculpted by readiness to perform ballistic head movements.

1. An acoustic startle stimulus delivered in place of a 'go' signal in a voluntary reaction time (RT) task has been shown previously to advance the onset latency of a prepared distal limb movement without affecting the amplitude of the muscle response or movement kinematics. The primary goal of this study was to use muscles with a larger startle response to investigate whether the startling stimulus only triggered the RT movement or whether some form of interaction occurred between a startle response and a temporally advanced RT movement. 2. Twenty healthy male or female subjects were instructed to react as quickly as possible to an acoustic 'go' stimulus by performing a ballistic head flexion or right axial rotation. The 'go' stimulus was periodically replaced by an acoustic stimulus capable of eliciting a startle reflex. Separate startle-inducing stimuli under relaxed conditions before and after the movement trials served as control trials (CT trials). Bilateral surface electromyography of the orbicularis oculi, masseter, sternocleidomastoid and cervical paraspinal muscles, and head-mounted transducers were used to measure the muscle response and movement kinematics. 3. Muscle activation times in startled movement trials (ST trials) were about half those observed in RT trials, and were not significantly different from those observed in the startle CT trials. The duration of head acceleration was longer in ST trials than in RT trials and the amplitude of both the neck muscle electromyogram (EMG) and head kinematics was larger during ST trials than during RT trials. The EMG amplitude of ST trials was biased upward rather than scaled upward compared with the EMG amplitude of RT trials. 4. Over the 14 ST trials used in this experiment, no habituation of the reflex response was observed in the muscles studied. This absence of habituation was attributed to a combination of motor readiness and sensory facilitation. 5. The results of this experiment indicated that the neck muscle response evoked by a startling acoustic stimulus in the presence of motor readiness could be described as a facilitated startle reflex superimposed on a temporally advanced, pre-programmed, voluntary RT movement. Parallel reticular pathways to the neck muscle motoneurones are proposed as a possible explanation for the apparent summation of the startle and voluntary movement responses.

Kinetic and Kinematic Responses of the RID2a, Hybrid III and Human Volunteers in Low-Speed Rear-End Collisions.

An anthropomorphic test device (ATD) which accurately models the kinematic and kinetic responses of human subjects during head restraint contact in low-speed rear-end collisions is needed to evaluate present and future seat and vehicle designs. The primary goal of this study was to quantify the biofidelity of a new rear-impact ATD, the RID2a, by comparing its dynamic response to those of human subjects under identical test conditions. For this study, a RID2a and a Hybrid III ATD were each exposed to 10 low-speed rear-end collisions: five at a speed change of 4 km/h and five at a speed change of 8 km/h. Sagittal plane kinematics of the head and upper torso, head restraint contact forces, and the reaction loads and moment at the atlanto-occipital joint were determined and compared to the response of eleven male human subjects. Both ATDs produced repeatable response corridors. As observed by others, the Hybrid III did not replicate many features of the human response. Aside from the vertical response of the head and T1 in the global reference frame, the kinematic and kinetic responses of the RID2a reproduced most features of the human response. Head restraint forces observed in both the human subjects and the RID2a contained large vertical components that placed the neck in tension during head restraint contact. The results of this study indicated that the RID2a was able to model the overall kinematic and kinetic responses relevant to some recently-proposed mechanisms of whiplash injury.

Cervical muscle response during whiplash: evidence of a lengthening muscle contraction.

OBJECTIVE: To assess the potential for cervical muscle injury from a rear-end automobile collision. DESIGN: Experimental design in which human subjects were exposed to low-speed rear-end collisions. The influence of independent variable (gender, speed change, muscle group, and motion phase) on dependent variables (kinematic response, muscle onset and muscle activation level) was examined using repeated-measures analysis of variance. BACKGROUND: Injuries to various tissues of the cervical spine have been proposed, yet little attention has been focused on the cervical muscles as a site of injury. METHODS: 42 subjects (21 males, 20-40 yr) were exposed to collisions of 4 and 8 km/h speed change while measuring kinematic response of the head and torso and electromyography of the sternocleidomastoid and cervical paraspinal muscles. RESULTS: Muscle activation occurred earlier in females and in the 8 km/h speed change. Sternocleidomastoid onset preceded paraspinal onset. Muscle activation level varied significantly with speed change, motion phase and muscle group. Initial rearward retraction of the head relative to the torso resulted in lengthening of the activated sternocleidomastoid, consistent with a contraction-induced muscle injury. CONCLUSIONS: The cervical muscles contract rapidly in response to impact and the potential exists for muscle injury due to lengthening contractions. RELEVANCE: The clinician should recognize the role of cervical retraction in the mechanism of whiplash injury and avoid aggressive motion in that plane during diagnosis and treatment. An understanding of whiplash injury mechanisms should improve patient education and preventative measures.

The relationship between clinical and kinematic responses from human subject testing in rear-end automobile collisions.

Recent experiments have produced a linked data set of clinical and kinematic responses for human subjects exposed to controlled low-speed rear-end collisions. The purpose of this paper was to examine this paired data set and determine whether the presence or absence of clinical symptoms could be predicted from the peak linear and angular kinematic response of the head and neck. The data were generated using 42 male and female human subjects seated normally in the front passenger seat of a stationary vehicle struck from behind to produce vehicle speed changes of 4 and 8 km/h. Pre- and post-test clinical examinations documented the presence, severity and duration of whiplash-associated disorders (WAD). Logistic regression and backward elimination of independent variables were used to develop the prediction model. The analysis yielded a 16 parameter model that was significantly related (odds ratio = 21.2; P = 0.0069) to the presence or absence of transient whiplash symptoms. The model correctly predicted symptom presence in 13 of 23 tests (sensitivity 57%) and symptom absence in 49 of 52 tests (specificity 94%) in a population of 75 with a symptom prevalence of 31%. The model's positive predictive value was 81% and its negative predictive value was 83%. Despite statistical significance, the model did not discriminate between the presence and absence of symptoms in all tests, and indicated that factors other than the selected peak kinematic responses influenced symptom production.

Seat back and head restraint response during low-speed rear-end automobile collisions.

Automobile seat backs and head restraints play a key safety role during low-speed rear-end collisions, yet few studies have explored the effect of collision variables on seat response. In this study, the effects of vehicle speed change and seat belt use on dynamic seat back and head restraint response during low-speed rear-end automobile collisions were examined. Four human subjects were repeatedly exposed to vehicle-to-vehicle rear-end collisions with speed changes of 2, 4, 6 and 8 km/h. Seat back force and deflection, and head restraint force were measured. The point of application of the resultant force applied to the seat back and head restraint were determined. The magnitude and time of peak kinematic and kinetic response parameters were used in a two-way repeated-measures analysis of variance (ANOVA) for speed change and seat belt use. The results showed that 20 of the 24 seat back and head restraint response parameters varied with speed change and none of the parameters varied with seat belt use. Head restraint forces, seat back forces and seat back deflections increased approximately linearly with speed change, whereas time to peak response, direction and moment arm of the forces remained either constant or varied only slightly over the range of speed changes tested.

Human Cervical Motion Segment Flexibility and Facet Capsular Ligament Strain under Combined Posterior Shear, Extension and Axial Compression.

The cervical facet capsular ligaments are thought to be an important anatomical site of whiplash injury, although the mechanism by which these structures may be injured during whiplash remains unclear. The purpose of this study was to quantify the intervertebral flexibility and maximum principal strain in the facet capsular ligament under combined shear, bending and compressive loads similar to those which occur during whiplash loading. Two motion segments (C3-4 and C5-6) from seven female donors (50 +/- 10 years) were exposed to quasi-static posterior shear loads of 135 N applied to the superior vertebra on four occasions while under compressive axial preloads of 0 N, 45 N, 197 N and 325 N. Vertebral body motions and the full Lagrangian strain field in the right facet capsular ligament were measured using stereophotogrammetry. After flexibility testing, the right facet joint of each motion segment was isolated and failed in posterior shear. Differences in the kinematic response of the vertebrae and maximum principal strain in the capsular ligaments under the four axial preloads were tested using repeated-measures ANOVA's for each load step. Although significant differences were observed at two axial load levels in the kinematic sequence (197 N and 325 N), neither the regressed flexibility nor the maximum principal strain in the facet capsular ligament varied significantly with axial compression (p > 0.14). Maximum principal strain during the flexibility tests reached 61 +/- 33 percent of the maximum principal strain observed in sub-catastrophic failures of the isolated joints. Two of the thirteen specimens reached strains in their flexibility tests which were larger than their corresponding strains at sub-catastrophic failure in the failure tests. These results suggest that the cervical facet capsular ligaments may be injured under combined shear, bending and compression load levels that occur in rear-end impacts.

Ventilation and locomotion coupling in varsity male rowers.

Ventilation and locomotion coupling (entrainment) has been observed and described in rowers during incremental exercise protocols but not during simulated race conditions. The purpose of this descriptive study was to examine ventilation and locomotion entrainment on a breath-by-breath and stroke-by-stroke basis in varsity male rowers during a maximal 2,000-m ergometer test. Eight of eleven rowers entrained ventilation at integral multiples of stroke rate (1:1, 2:1, or 3:1) for at least 120 consecutive seconds, with a 2:1 entrainment pattern being most common. In all 2:1-entrained subjects, inspiration occurred at catch and finish and expiration occurred during the latter portions of drive and recovery. In entrained and unentrained breaths from all rowers, peak flow rates and tidal volumes varied depending on when the breath was initiated during the stroke cycle. Entrained rowers made use of these differences and breathed in a pattern by which they avoided initiating breaths that resulted in reduced tidal volumes. The present data indicated that ventilation was impaired at stroke finish and not at catch, as hypothesized by some previous researchers. Ventilation also appeared to be subordinate to consistent locomotive patterns under race conditions.

The influence of head restraint and occupant factors on peak head/neck kinematics in low-speed rear-end collisions.

Prior two-way analyses of variance showed that the peak kinematic response of the head and neck of subjects exposed to low-speed rear-end collisions was related to speed change and gender, however potential reasons for this gender dependence were not determined. Using multiple linear regression, this study further examined these response data to determine the relative influence of specific factors, including subject anthropometry, neck strength, cervical range of motion, seated posture and head restraint position, which may have been responsible for the previously-observed gender dependence. The results of this analysis showed that vehicle speed change and relative head restraint position explained the largest proportion of the observed variation in peak occupant kinematic response. Seated posture measures also explained some of the variation in kinematic response. The current analysis prioritizes which variables to explore more thoroughly in future research and which variables should be carefully controlled in future studies.

Clinical response of human subjects to rear-end automobile collisions.

OBJECTIVE: Forty-two persons were exposed to controlled low-speed rear-end automobile collisions to assess the relation between both gender and impact severity and the presence, severity, and duration of whiplash-associated disorders (WAD). Individual measures were also assessed for their potential to predict the onset of WAD. DESIGN: Experimental study subjecting individuals to a speed change of 4 km/h and 8 km/h and utilizing pretest and posttest physical examinations (immediately after and 24 hours after impact) to quantify subjects' clinical response. RESULTS: Approximately 29% and 38% of the subjects exposed to the 4 km/h and 8 km/h speed changes, respectively, experienced WAD symptoms, with cervical symptoms and headaches predominating. Objective clinical deficits consistent with WAD were measured in both men and women subjects at both 4 km/h and 8 km/h. At 4 km/h, the duration of symptoms experienced by women was significantly longer when compared with that in men (p < .05). There were no significant differences in the presence and severity of WAD between men and women at 4 km/h and 8 km/h or in the duration of WAD at 8 km/h. There was also no significant difference in the presence, severity, and duration of WAD between 4 km/h and 8 km/h. No preimpact measures were predictive of WAD. CONCLUSION: The empirical findings in this study contribute to establishing a causal relationship between rear-end collisions and clinical signs and symptoms.

Preparación preoperatoria abreviada en enfermedad de Basedow Graves / Abreviated presurgical preparation in Basedow Graves disease

Con el propósito de determinar la factibilidad de realizar una preparación preoperatoria abreviada mediante el uso de dexametasona(Dex) e iodato de sodio(IS) en pacientes con EBG, se analizan prospectivamente 11 casos tratados entre febrero de 1985 y abril de 1987. Su hipertiroidismo se determinó por hallazgos clínicos y de laboratorio y se sometieron a tiroidectomía subtotal bilateral, una vez obtenido el eutiroidismo, al 4o día de iniciada la preparación. Durante la intervención se evaluó el comportamiento hemodinámico y las características de la glándula, con el fin de establecer los efectos de agresión anestésico quirúrgica, observándose estabilidad hemodinámica y moderada disminución de la hipervascularización glandular. Mediante microscopia óptica y electrónica de las glándulas extirpadas se evaluaron las alteraciones histológicas producidas por la Dex e IS. No se registró mortalidad y sólo 2 ,pacientes presentaron seroma de herida operatoria

[Early operation in acute cholecystitis]. / L'intervento precoce nella colecistite acuta.

104 patients with acute cholecystitis were divided into four groups according to the kind of pre-operative treatment received: immediate; early; late; and interval operation. Total duration of hospital stay depended on the duration of pre-operative treatment. It was shortest (24.9 days) in those operated on within the first week, longest (71.1 days) in those operated on during the interval. Evidence of severe gallbladder wall changes (macroscopic and microscopic) was obtained in two thirds of patients, even after weeks of conservative treatment. Six patients (5.7%) died postoperatively, three of them after early operation. Overall mortality was only in part due to severe complications of the gallbladder disease.

[Early operation for acute cholecystitis (author's transl)]. / Zur Frühoperation der akuten Cholezystitis.

104 patients with acute cholecystitis were divided into four groups according to the kind of pre-operative treatment received: immediate; early; late; and interval operation. Total duration of hospital stay depended on the duration of pre-operative treatment. It was shortest (24.9 days) in those operated on within the first week, longest (71.1 days) in those operated on during the interval. Evidence of severe gallbladder wall changes (macroscopic and microscopic) was obtained in two thirds of patients, even after weeks of conservative treatment. Six patients (5.7%) died postoperatively, three of them after early operation. Overall mortality was only in part due to severe complications of the gallbladder disease.

[The socio-medical significance of chronic rheumatoid arthritis (proceedings)]. / Die sozialmedizinische Bedeutung des chronischen Gelenksrheumatismus.

The last figures, portraying to the cost complex concerning rheumatism, have been released by the Austrian Health Insurance Organisation. Attention is called to the problem of unauthorized sick leave and to the cooperation of all pertinently concerned, with regards controlling cost inflation.