[Recombinant human erythropoietin in anemia associated with pediatric cancer: study of the identification of predictors of response]. / Eritropoyetina recombinante humana en la anemia asociada al cáncer infantil: estudio de la identificación de factores predictivos de la respuesta.

OBJECTIVE: Cancer is frequently associated with anemia and may be related to inadequate erythropoietin production. The objective of this study was to assess the efficacy and safety of recombinant human erythropoietin (r-HuEPO) in increasing hemoglobin levels and reducing the need of blood transfusions in children with cancer, as well as to identify predictors of the response to r-HuEPO. PATIENTS AND METHODS: A pilot trial was performed including 25 patients with solid malignant tumors receiving cyclic chemotherapy, r-HuEPO was administered subcutaneously, 150 U/kg/day 5 times a week for 12 consecutive weeks. Response was defined as the achievement of a Hb increase of at least 2 g/dl without blood transfusions. Patients were compared to history matched controls. RESULTS: Baseline parameters were similar (p > 0.05) in both groups. The mean Hb increase was greater in the r-HuEPO group compared to controls (2.6 vs 0.1 g/dl; p < 0.001) and the mean units of blood transfused were lower in treated patients (0.32 vs 2.36; p < 0.05). Response to r-HuEPO was achieved in 19 (76%) patients. Low baseline erythropoietin levels and an increase in Hb of at least 0.5 g/dl after 3-4 weeks of treatment defined a greater probability of response. No serious adverse effects were observed. CONCLUSIONS: r-HuEPO treatment represents a safe and effective means of increasing Hb levels and reducing blood requirements in pediatric cancer patients receiving chemotherapy and the prediction of response may be based on baseline serum erythropoietin levels and on the variation of Hb levels after 3-4 weeks of treatment.

Partial splenic embolisation and improvement of hypersplenism before liver transplantation.

A case of partial splenic embolisation (PSE) that was performed in a girl with severe leucothrombocytopenia due to hypersplenism is described. Treatment with PSE is a safe and effective alternative to splenectomy that prevents clinical complications due to haematological disorders and improves hypersplenism before liver transplantation.

[Malignant fibrous histiocytoma of the orbit as second tumor in a case of bilateral retinoblastoma]. / Histiocitoma fibroso maligno de la órbita como segundo tumor en un caso de retinoblastoma bilateral.

The case of a 30 months-old child with malignant fibrous histiocytoma of the left orbit diagnosed 18 months after treatment with external beam radiotherapy for bilateral retinoblastoma is presented. The clinical and histological characteristics of malignant fibrous histiocytoma and its relation as a second malignant tumor in patients affected with retinoblastoma are analyzed.