RESUMO
This review article utilizes the technique of citation-based bibliometric analysis to provide a comprehensive understanding of the scholarly contributions made by sociologist Michael Burawoy. The most influential academic articles published by Burawoy were retrieved for analyses. Following this, scholars, journals and institutions that he most frequently collaborated with were traced. Further, country-wise analysis of his scholarship was carried out. Lastly, content analyses of retrieved articles identified prominent thematic domains in sociology to which Burawoy contributed, while temporal analyses helped to identify some emerging research hotspots. Findings reveal that historical and cultural context of Burawoy's research mostly remained confined to the U.S.A., however, he significantly contributed towards the foundation of sociology in the Global South and studied the ensuing global power imbalances. Contemporary sociological thought remains indebted to Burawoy for his comparative study of industrial relations in the 21st century, and recently, his elaboration upon the need for public sociology has taken the discipline in new intellectual directions that appeals to a broader sociological community.
RESUMO
Alcohol use disorder (AUD) requires new neurobiological targets. Problematic drinking involves underactive indirect pathway medium spiny neurons (iMSNs) that subserve adaptive behavioral selection vs. overactive direct pathway MSNs (dMSNs) that promote drinking, with a shift from ventromedial to dorsolateral striatal (VMS, DLS) control of EtOH-related behavior. We hypothesized that inhibiting phosphodiesterase 10A (PDE10A), enriched in striatal MSNs, would reduce EtOH self-administration in rats with a history of chronic intermittent ethanol exposure. To test this, Wistar rats (n = 10/sex) with a history of chronic intermittent EtOH (CIE) vapor exposure received MR1916 (i.p., 0, 0.05, 0.1, 0.2, and 0.4 µmol/kg), a PDE10A inhibitor, before operant EtOH self-administration sessions. We determined whether MR1916 altered the expression of MSN markers (Pde10a, Drd1, Drd2, Penk, and Tac1) and immediate-early genes (IEG) (Fos, Fosb, ΔFosb, and Egr1) in EtOH-naïve (n = 5-6/grp) and post-CIE (n = 6-8/grp) rats. MR1916 reduced the EtOH self-administration of high-drinking, post-CIE males, but increased it at a low, but not higher, doses, in females and low-drinking males. MR1916 increased Egr1, Fos, and FosB in the DLS, modulated by sex and alcohol history. MR1916 elicited dMSN vs. iMSN markers differently in ethanol-naïve vs. post-CIE rats. High-drinking, post-CIE males showed higher DLS Drd1 and VMS IEG expression. Our results implicate a role and potential striatal bases of PDE10A inhibitors to influence post-dependent drinking.