RESUMO
OBJECTIVE: Despite the link between positive coronary remodelling and acute ischaemic events, no data exist about the impact of arterial remodelling on subsequent progression of coronary atherosclerosis. The objective of this study was to examine whether extent and direction of arterial remodelling are predictors of progression of coronary atherosclerosis. DESIGN, SETTING AND PATIENTS: From the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial, 210 focal coronary lesions (single lesion per patient) were identified with Assuntos
Doença da Artéria Coronariana/diagnóstico por imagem
, Vasos Coronários/diagnóstico por imagem
, Ultrassonografia de Intervenção/métodos
, Adulto
, Idoso
, LDL-Colesterol/efeitos dos fármacos
, LDL-Colesterol/metabolismo
, Angiografia Coronária/métodos
, Doença da Artéria Coronariana/tratamento farmacológico
, Doença da Artéria Coronariana/fisiopatologia
, Progressão da Doença
, Feminino
, Seguimentos
, Humanos
, Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
, Masculino
, Pessoa de Meia-Idade
, Valor Preditivo dos Testes
, Ensaios Clínicos Controlados Aleatórios como Assunto
, Resultado do Tratamento
RESUMO
BACKGROUND: Long-term survival after heart transplantation is a desirable although challenging goal. METHODS: We analyzed clinical outcomes in the cohort of 170 patients who have undergone heart transplantation at The Cleveland Clinic Foundation and survived >10 years. RESULTS: We found 10-year and 15-year survival rates of 54% and 41%, respectively, in these patients, but there was also a high incidence of complications, such as hypertension, renal dysfunction, transplant vasculopathy, and malignancy. CONCLUSIONS: Long-term survival following cardiac transplantation is possible although complications are frequent. Beyond 10 years, malignancy is a major cause of death.