[Serological assay in the assessment of the trichinosis epidemiological situation in the Tiumen' region]. / Serologicheskii metod issledovaniia v otsenke épidsituatsii po trikhinellezu v Tiumenskoi oblasti.

A total of 3022 sera from patients with suspected trichinosis and healthy individuals were studied by enzyme immunoassay using the commercial test systems of the Ye.I. Martsinovsky Institute of Medical Parasitology and Tropical Medicine (Moscow) and of the private joint stock company "Vector-Best" (Novosibirsk). The study indicated the trichinosis situation of strain in all subjects of the Russian Federation, including the Tyumen Region. The proportion of positive serological assays during diagnostic studies was 15.4%, that of seroepidemiological surveys was 3.3%. This poor situation associated with this entity is confirmed by group, "familial", and single cases of clinical trichinosis associated with ingestion of the meat of brown bears, badgers, and dogs and pork. The presence of natural trichinosis foci in the Tyumen Region is unquestionable, there is no evidence for formed synanthropic foci. An increase in the risk of trichinosis infection in the region is favoured by both socioeconomical and environmental epizootological prerequisites associated with the factors of technogenic and anthropic pressure on the ecosystem. Growing epidemic hazard of trichinosis foci requires that controlling and preventive measures shall be included into social development programmes for the districts and south of the Tyumen Region.

[The fundamentals of association of natural foci of zoonoses]. / Ob osnovakh assotsiirovannosti prirodnykh ochagov zoonozov.

Reports on the role of hydrological conditions in the functioning of parasitic systems are analyzed. The authors point out that a range of issues including different aspects of combination phenomena is discussed there. They suggest that a concept of combination shall be replaced by a concept of association of parasitic systems and their relevant natural foci of zoonoses, which is of a larger scope. The fundamentals of the formation and functioning of associated parasitic systems and natural foci of zoonoses are discussed. These include the hydrological conditions of floodplain-river regions, the multiparasitic capacity of hosts and vectors, the multihost pattern of causative agents, and a diversity of mechanisms of their transmission. The transmission mechanism without which movement of causative agents and the existence of parasitic systems and foci are impossible is shown to be a global combining onset of parasitic systems. The hydrological conditions of floodplain-river regions act as the universal mechanism of transmission of pathogens. The dynamics of the mechanism determines the functioning of all other mechanisms of transmission.

[The first trial of treating opisthorchiasis with the Soviet preparation azinoks]. / Pervyi opyt lecheniia opistorkhoza otechestvennym preparatom azinoksom.

7 patients in the acute and 51 patients in the chronic stages of opisthorchiasis were treated with azynoks in daily dose 60 mg per kilo. The radical cure was achieved in 95.8 +/- 0.4% of cases. The wild side effects (headache, vertigo, nausea, fatigue) were registered in 51.7 +/- 9.1% of the cases, predominantly during the first hours of the treatment. The biochemical and immunological changes during the first 2 weeks after azynoks administration were analogues to those seen after biltricide and chloxyl (hexaparaxylol) treatment.