RESUMO
Genetic analysis was carried out on the material including clinic and genealogical data about 510 patients with type 2 Diabetes Mellitus, 445 Essential Hypertension individuals, 239 abdominal obesity persons and their 1st degree relatives. It has been shown that the Essential Hypertension and abdominal obesity distribution in the population and families can be described by means of a variants polygene model with essential influence of the major genes. Gene complexes of predisposition to obesity, Essential Hypertension and Type 2 Diabetes Mellitus are independent, however, their liabilities are covered.
Assuntos
Constituição Corporal , Predisposição Genética para Doença , Síndrome Metabólica/genética , Característica Quantitativa Herdável , Adulto , Constituição Corporal/genética , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/genética , Feminino , Testes Genéticos , Genética Populacional , Humanos , Hipertensão/epidemiologia , Hipertensão/genética , Masculino , Síndrome Metabólica/epidemiologia , Obesidade Abdominal/epidemiologia , Obesidade Abdominal/genética , LinhagemRESUMO
Studied in the course of one-stage epidemiologic survey of 1191 individuals were the threshold of gustatory sensitivity to table salt and nycterine natriuresis, relation of these indices to dietary habits, some risk factors for cardiovascular disorders and clinical parameters. Differing relations were established between gustatory sensitivity to table salt and natriuresis and age and gender of the examinees, the level of blood pressure, aggravated heredity in respect of arterial hypertension, smoking and alcohol abuse, this enabling one to embark upon a differential approach to dietetic correction of salt consumption.
Assuntos
Natriurese , Saúde Ocupacional , Cloreto de Sódio , Limiar Gustativo/efeitos dos fármacos , Adulto , Fatores Etários , Pressão Sanguínea , Índice de Massa Corporal , Suscetibilidade a Doenças , Comportamento Alimentar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Saúde Ocupacional/estatística & dados numéricos , Fatores de Risco , Fatores Sexuais , UcrâniaRESUMO
Contents of free amino acids and some biogenic amines were studied in hypertonic patients at the age of 40-50 years. The study demonstrates quantitative changes in levels of free amino acids and some biogenic amines caused by disorders of protein metabolism. The data obtained may be used for diagnosis of hypertonic diseases.