Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros








Base de dados
Intervalo de ano de publicação
1.
J Med Econ ; 16(1): 10-8, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22947171

RESUMO

OBJECTIVE: This retrospective study evaluated iron chelating therapy (ICT) discontinuation and costs in Sickle cell disease (SCD) Medicaid recipients using healthcare claims from 2006-2010. METHODS: Patients with ≥1 SCD diagnosis claim, ≥2 claims for deferoxamine (DFO) or deferosirox (DFX), and continuous enrollment ≥6 months prior to and 18 months following ICT initiation were included. Outcomes included treatment discontinuation, persistence (i.e., refill gaps ≥6 weeks), and total healthcare costs. RESULTS: The average age among 404 SCD patients meeting study inclusion criteria was 18.7 (±11.0) years, with 45.8% being males and 66.7% being Blacks. Switches or combinations from DFO at index occurred in 124 (74.7%) patients compared to 10 (4.2%) with DFX at index. The Cox regression model that assessed long-term medication persistence indicated a 1.30-times higher likelihood of treatment discontinuation with DFO compared to DFX (95% CI: 1.06-1.61). Some 19.7% of patient remained on DFX relative to 4.8% on DFO. Both inpatient and total costs were similar in DFX and DFO treatment groups. Following 1 year of treatment, 37.4% remained on DFX compared to 15.7% on DFO. Meaningful differences in treatment discontinuation between the two treatment groups did not occur until 220+ days during the study period. At 18-months, treatment discontinuation rates were high in both groups; 95% for DFO and 80% for DFX. CONCLUSION: This study of SCD Medicaid patients found more therapeutic switches from DFO to DFX and a higher medication persistency rate with DFX than DFO. The conclusions are limited by the study's retrospective nature, which depends on multivariate statistics to account for patient heterogeneity and risk factors.


Assuntos
Anemia Falciforme/tratamento farmacológico , Benzoatos/economia , Desferroxamina/economia , Quelantes de Ferro/economia , Medicaid/estatística & dados numéricos , Triazóis/economia , Adolescente , Adulto , Fatores Etários , Anemia Falciforme/economia , Anemia Falciforme/epidemiologia , Benzoatos/uso terapêutico , Transfusão de Sangue , Criança , Deferasirox , Desferroxamina/uso terapêutico , Uso de Medicamentos , Feminino , Gastos em Saúde , Humanos , Revisão da Utilização de Seguros/estatística & dados numéricos , Quelantes de Ferro/uso terapêutico , Estimativa de Kaplan-Meier , Masculino , Adesão à Medicação/estatística & dados numéricos , Preferência do Paciente/estatística & dados numéricos , Modelos de Riscos Proporcionais , Grupos Raciais/estatística & dados numéricos , Estudos Retrospectivos , Fatores Sexuais , Triazóis/uso terapêutico , Estados Unidos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA