Diffusion in the corpus callosum predicts persistence of clinical symptoms after mild traumatic brain injury, a multi-scanner study.

Background: Mild traumatic brain injuries (mTBIs) comprise 80% of all TBI, but conventional MRI techniques are often insensitive to the subtle changes and injuries produced in a concussion. Diffusion tensor imaging (DTI) is one of the most sensitive MRI techniques for mTBI studies with outcome and symptom associations described. The corpus callosum (CC) is one of the most studied fiber tracts in TBI and mTBI, but the comprehensive post-mTBI symptom relationship has not fully been explored. Methods: This is a retrospective observational study of how quantitative DTI data of the CC and its sub-regions may relate to clinical presentation of symptoms and timing of resolution of symptoms in patients diagnosed with uncomplicated mTBI. DTI and clinical data were obtained retrospectively from 446 (mean age 42 years, range 13-82) civilian patients. From patient medical charts, presentation of the following common post-concussive symptoms was noted: headache, balance issues, cognitive deficits, fatigue, anxiety, depression, and emotional lability. Also recorded was the time between injury and a visit to the physician when improvement or resolution of a particular symptom was reported. FA values from the total CC and 3 subregions of the CC (genu or anterior, mid body, and splenium or posterior) were obtained from hand tracing on the Olea Sphere v3.0 SP12 free-standing workstation. DTI data was obtained from 8 different 3T MRI scanners and harmonized via ComBat harmonization. The statistical models used to explore the association between regional Fractional Anisotropy (FA) values and symptom presentation and time to symptom resolution were logistic regression and interval-censored semi-parametric Cox proportional hazard models, respectively. Subgroups related to age and timing of first scan were also analyzed. Results: Patients with the highest FA in the total CC (p = 0.01), anterior CC (p < 0.01), and mid-body CC (p = 0.03), but not the posterior CC (p = 0.91) recovered faster from post-concussive cognitive deficits. Patients with the highest FA in the posterior CC recovered faster from depression (p = 0.04) and emotional lability (p = 0.01). There was no evidence that FA in the CC or any of its sub-regions was associated with symptom presentation or with time to resolution of headache, balance issues, fatigue, or anxiety. Patients with mTBI under 40 had higher FA in the CC and the anterior and mid-body subregions (but not the posterior subregion: p = 1.00) compared to patients 40 or over (p ≤ 0.01). There was no evidence for differences in symptom presentation based on loss of consciousness (LOC) or sex (p ≥ 0.18). Conclusion: This study suggests that FA of the CC has diagnostic and prognostic value for clinical assessment of mTBI in a large diverse civilian population, particularly in patients with cognitive symptoms.

Quadrilateral space region inflammation and other incidental findings on shoulder MRI following recent COVID-19 vaccination: Three case reports.

We present 3 cases reporting the normal appearance of the post COVID-19 vaccination on shoulder MRI exams. All 3 patients were imaged 1 to 5 days post-vaccination for unrelated MSK shoulder symptoms, and none reported any symptoms besides mild shoulder discomfort for a day or 2 following vaccine administration. All 3 patients demonstrated characteristic deltoid edema, quadrilateral space region edema and axillary nodal prominence. Vessel prominence with t2 and t1 increased signal draining to the approximate location of the quadrilateral space and axilla was an associated feature. The normal appearance of the covid-19 vaccine on shoulder MRI has not been previously described, and recognition by the radiologist will prevent erroneous differential diagnosis, unnecessary medical workups, and detract from the clinically relevant pathological imaging findings in patients with shoulder pain.

FEVER: The Flexed Elbow Valgus External Rotation View for MRI Evaluation of the Ulnar Collateral Ligament in Throwing Athletes-A Pilot Study in Major League Baseball Pitchers.

BACKGROUND. Ulnar collateral ligament (UCL) injuries are common in throwing athletes owing to repetitive extreme valgus stress during overhead throwing maneuvers. Conventional positioning for elbow MRI provides suboptimal rendering of the UCL. OBJECTIVE. The purpose of this prospective pilot study was to assess the effect of flexed elbow valgus external rotation (FEVER) on ulnotrochlear joint space measurement and reader evaluation of the UCL when the FEVER view is incorporated into standard elbow MRI of throwing athletes. METHODS. A total of 44 Major League Baseball pitchers underwent elbow MRI including standard sequences and a coronal fat-saturated proton density-weighted sequence in the FEVER view. To achieve the FEVER view, specific positioning maneuvers are performed, and sandbags are placed to immobilize the elbow in valgus stress so that the UCL can be visualized parallel to its long axis. Patients recorded pain during FEVER on a scale of 0 (none) to 10 (maximal). Two radiologists independently evaluated standard and FEVER images to measure the ulnotrochlear joint space, assess confidence in UCL-related findings, and assess the UCL as normal or abnormal. RESULTS. Pain during FEVER was rated 0 by 29 patients, 1-3 by 11 patients, 4-7 by four patients, and 8-10 by no patients. Intrareader agreement on ulnotrochlear joint space measurement was higher for FEVER (intraclass correlation coefficient [ICC], 0.92) than standard (ICC, 0.54) views. Averaged between readers, the mean increase in ulnotrochlear joint space in the FEVER compared with the standard view was 1.80 mm (95% CI, 1.58-2.03). Confidence was higher for the FEVER than for the standard view for reader 1 in assessment of the UCL as normal versus abnormal (mean increase in confidence, 0.40), intensity of abnormal signal (0.39), injury grade (1.04), and retraction (0.25) and for reader 2 in assessment of the UCL as normal versus abnormal (0.50), location of abnormal signal (0.46), intensity of abnormal signal (0.51), injury grade (0.96), and retraction (0.53). Readers 1 and 2 classified three and two additional UCLs as abnormal on FEVER view compared with standard view images; neither reader classified any UCL as abnormal on standard view but normal on FEVER view images. CONCLUSION. The increased joint space width confirmed elbow valgus stress in the FEVER view. Diagnostic confidence increased, and additional UCLs were identified as abnormal. CLINICAL IMPACT. Use of the FEVER view may improve MRI evaluation of the UCL in throwing athletes.

The "Cone-Head" sign: Magnetic resonance image findings of the "Headspin Hole", an overuse injury found in breakdancers.

Breakdancing can cause the formation of a painless lump on the scalp at the vertex of the skull, with associated hair loss called a "Headspin Hole." This occurs secondary to chronic inflammation from performing spinning dance moves on the head. We present the radiological findings of the "Headspin Hole" in a 38-year-old male with a history of breakdancing. Magnetic resonance imaging revealed a cone-shaped deformity on the vertex of the skull with deep scalp thickening adjacent to the outer-table cortex. Currently in the literature, there is no description of the radiological findings of this cone-shaped deformity on the vertex of the skull, we refer to this as the "Cone-Head Sign."

Quantitative EEG Biomarkers for Mild Traumatic Brain Injury.

PURPOSE: The development of objective biomarkers for mild traumatic brain injury (mTBI) in the chronic period is an important clinical and research goal. Head trauma is known to affect the mechanisms that support the electrophysiological processing of information within and between brain regions, so methods like quantitative EEG may provide viable indices of brain dysfunction associated with even mTBI. METHODS: Resting-state, eyes-closed EEG data were obtained from 71 individuals with military-related mTBI and 82 normal comparison subjects without traumatic brain injury. All mTBI subjects were in the chronic period of injury (>5 months since the time of injury). Quantitative metrics included absolute and relative power in delta, theta, alpha, beta, high beta, and gamma bands, plus a measure of interhemispheric coherence in each band. Data were analyzed using univariate and multivariate methods, the latter coupled to machine learning strategies. RESULTS: Analyses revealed significant (P < 0.05) group level differences in global relative theta power (increased for mTBI patients), global relative alpha power (decreased for mTBI patients), and global beta-band interhemispheric coherence (decreased for mTBI patients). Single variables were limited in their ability to predict group membership (e.g., mTBI vs. control) for individual subjects, each with a predictive accuracy that was below 60%. In contrast, the combination of a multivariate approach with machine learning methods yielded a composite metric that provided an overall predictive accuracy of 75% for correct classification of individual subjects as coming from control versus mTBI groups. CONCLUSIONS: This study indicates that quantitative EEG methods may be useful in the identification, classification, and tracking of individual subjects with mTBI.

Whole-spine dynamic magnetic resonance study of contortionists: anatomy and pathology.

OBJECT: Whole-spine magnetic resonance (MR) images were obtained using a cylindrical 3-T MR imaging system in 5 contortionists to assess the pathological changes possibly associated with the practice of contortion. Whole-spine dynamic MR images were obtained using a 1-T open MR imaging system in 2 of these contortionists with the purpose of defining the range of motion (ROM) achieved during extreme contortion. The range of spinal motion in this unique population was then quantified. METHODS: The study included 5 female contortionists 20-49 years of age. Imaging was performed using open 1-T and cylindrical 3-T high-field MR imaging systems. Data were viewed and analyzed with DICOM-compliant tools. Real-time, dynamic, and standard MR imaging allowed for quantification of the contortionists' ROM. RESULTS: There was a difference of 238 degrees between full spinal extension and full flexion. Three of the 5 contortionists had 4 anterosuperior limbus vertebrae at T-11 and the upper lumbar levels. CONCLUSIONS: Whole-spine dynamic MR imaging is a valuable tool for the evaluation of the extreme ROM in contortionists, allowing for the quantification of extreme mobility. The limbus fractures present in 3 of the 5 contortionists is postulated to be due to avulsion on hyperextension. Future research may open the use of whole-spine dynamic MR imaging into such areas as pain management and traumatic spinal injuries.