Ibero-American Expert Consensus on Squamous Cell Carcinoma of the Head and Neck Treatment in Patients Unable to Receive Cisplatin: Recommendations for Clinical Practice.

Cisplatin is the standard of treatment for squamous cell carcinoma of the head and neck (SCCHN) that has demonstrated efficacy, either in locally advanced disease when combined with radiotherapy at high doses, or in metastatic/recurrent disease when combined with other agents. However, the usual toxicities related to cisplatin, such as neurotoxicity, nephrotoxicity, ototoxicity, and hematologic toxicities, especially when high doses have been administered, have important implications in the patients' quality of life. The decision to administer cisplatin depends on several patient factors, such as age, performance status, weight loss, comorbidities, previous toxicities, chronic viral infection, or even the current SARS-CoV-2 pandemic. In order to establish recommendations for the management of patients with SCCHN, a group of experts in medical and radiation oncology from Spain and Latin-American discussed how to identify patients who are not candidates for cisplatin to offer them the most suitable therapeutic alternative.

Tuberculosis colónica: A propósito de un caso / Colonic tuberculosis: Report of a case

La tuberculosis (TB) es una enfermedad causada por una bacteria alcohol-ácido resistente, el Mycobacterium tuberculosis (MT). Se estima que en la actualidad un tercio de la población mundial está infectada con este bacilo,1,2 sin embargo, no todos los individuos infectados tienen enfermedad clínica, presentándose esta cuando el sistema inmune está comprometido. Esta enfermedad puede comprometer diferentes aparatos y sistemas, con afección principalmente pulmonar. La TB intestinal representa el 3 al 5% de todas las manifestaciones extrapulmonares.2,3,4 Para el diagnóstico de TB en colon se requiere un alto índice de sospecha por ser el colon un sitio que se afecta poco y porque los síntomas no son específicos.5,6 Presentamos el caso clínico de un paciente ingresado por TB pulmonar a quien solicitan interconsulta a gastroenterología por examen de sangre oculta positivo, realizándosele colonoscopia con toma de biopsia que concluye TB de colon.

Tuberculosis (TB) is a disease caused by an acid-alcohol resistant bacteria, Mycobacterium tuberculosis (MT). It is estimated that currently one third of the world population is infected with this bacillus, however, not all individuals infected develop the clinical disease, presenting this when the immune system is compromised. This disease may involve different organ systems with mainly pulmonary condition and intestinal TB accounts for 3 to 5% of all extrapulmonary manifestations.2,3,4 The diagnosis of TB in colon requires a high index of suspicion for being the colon a site that has little affection and because the symptoms are not specific.5,6 We report a case of a patient admitted for pulmonary TB who had positive occult blood test, they request evaluation to Gastroenterology performing a colonoscopy with biopsy that report colon TB.