Coexistence of tooth agenesis and ovarian cancer - a systematic literature review.

OBJECTIVES: Dental agenesis - a congenital lack of teeth - is one of the most frequently diagnosed developmental defects of dentition. Genetics is a crucial factor in the etiology of this disorder. Missing teeth can be caused by mutation in genes including MSX1, PAX9, AXIN2, and EDARADD. As is also true for ovarian cancer, over 20% of cases are associated with hereditary factors. Mutations in the BRCA1 and BRCA2 genes are said to be the most frequent of these. The aim of this study was to provide a systematic review of the literature on the coexistence of ovarian cancer and tooth agenesis. MATERIAL AND METHODS: Publications were searched for in the online databases PubMed, SCOPUS, and Wiley Online Library. Current and archival issues of the Journal of Stomatology and Dental and Medical Problems were also searched. The key words used to find relevant publications were: ovarian cancer, hypodontia, and tooth agenesis, in various combinations. RESULTS: Three publications were qualified to this review. Two of these compared the incidence of hypodontia in women with ovarian cancer and in healthy women, and the other was aimed at locating the gene responsible for the coexistence of ovarian cancer and tooth agenesis. As shown by these studies, women with ovarian cancer are (depending on the study) 3.3 or 8.1 times more likely to have hypodontia than healthy women. However, no specific gene was found that might be responsible for the coexistence of ovarian cancer and tooth agenesis.

Assessment of the implementation of the infectious diseases screening programmes among pregnant women in the Lesser Poland region and comparison with similar programmes conducted in other European Union countries.

OBJECTIVES: The aim of the study was to assess the level of implementation of recommendations of the Ministry of Health regarding infectious disease screening during pregnancy. MATERIAL AND METHODS: The study included 477 patients who were admitted to the delivery room between December 2015 and February 2016. Data on screening test results were collected based on medical records covering the period before the admission. RESULTS: The Human Immunodeficiency Virus (HIV) screening was conducted in 410 (86%). 460 (96%) of patients were screened for Hepatitis B Virus (HBV) and 427 (89.5%) for Hepatitis C Virus (HCV). Syphilis screening covered 465 (97.5%) of patients. Immunoglobulin M (IgM) titer against Rubella Virus (RV) was assessed in 218 (45%) patients and immunoglobulin G (IgG) in 319 (66.9%). Screening for Toxoplasma gondii based on assessment of IgM titer was conducted in 440 (92%) patients while IgG titter was assessed in 413 (86.6%). 343 (71.9%) patients had obtained vaginal swabs for Group B Streptococci (GBS) while the anal swabs were taken only from 268 (56.2%) patients. CONCLUSIONS: Coverage of screening for syphilis and HBV was similar to the countries with highest prevalence of conducting such screening, on the other hand RV screening place as among countries with lowest prevalence. There is an increasing trend in conducting HIV screening. Screening for HCV and toxoplasmosis is at satisfactory level and Poland is one of a few European countries offering such screening. The screening for GBS is insufficient which result in excessive use of intrapartum antibiotic prophylaxis.

[An influence of changes in the levels of leptin on the risk of preterm delivery in patients with excessive BMI].

Introduction: In the literature are found in only a few reports on the role of leptin in the etiology of preterm birth in pregnant women with excessive BMI. The aim of the study was to evaluate the relationship between leptin levels and the prevalence of symptoms of preterm labor as well as assessment of changes in leptin levels depending on the BMI and the effect of leptin on the state of postnatal neonatal determined by Apgar scale. Material and method: Prospective analysis applied to the data obtained from 80 patients hospitalized in the Department of Obstetrics and Perinatology University Hospital in Cracow. The study was prospective and cohort. The study included pregnant single diagnosed with a BMI greater than or equal to 25. Results: It had significantly higher levels of leptin in the group of patients with symptoms of pre-term labor and BMI≥25 compared to lower concentrations of leptin from the group of patients with a BMI <25 (p = 0.01414). It has been found higher levels of plasma leptin in patients with BMI≥25 compared to patients with a BMI <25, in the groups of patients during the nascent (0.0492). Conclusions: Pregnant with symptoms of preterm labor and excessive BMI had higher levels of leptin than women giving birth on time with abnormal, excessive BMI. It was found higher levels of leptin in the group of patients with symptoms of pre-term labor in comparison to the control groups, which may favor the severity of inflammation which is the cause of the symptoms of preterm labor. There was no correlation between the changes in leptin levels during pregnancy and the state natal infants based on the Apgar scale.