RESUMO
The 24-hour's changes in ATP content in the gastrocnemiuses of intact rast are not significant. Both the ADP and AMP content is subjected to 24-hour's variations. It reaches its maximum within the time period from 12 to 15 o'clock p.m. for ADP and at 18 o'clock p.m. for AMP. Intragastric administration of ethanol and ethylene glycol to rats in a dose of 1/3 LD50 once per 24-hour period at 9 a. m. during a 7-days-long period dramatically changes the 24-hour's rhythm of adenylic nucleotide content in the rat gastrocnemius. It has been found that ethanol increases the average 24-hour's content of ATP, but decreases that of ADP. It increases the range of their 24-hour period variations and changes the acrophase. Ethylene glycol decreases the average 24-hour content of the both ATP and ADP, but it increases that of AMP. It changes their acrophases and increases the ranges of 24-hour-period variations of ATP.
Assuntos
Nucleotídeos de Adenina/metabolismo , Ritmo Circadiano/efeitos dos fármacos , Etanol/farmacologia , Etilenoglicóis/farmacologia , Músculos/efeitos dos fármacos , Ácidos Nicotínicos/farmacologia , Oxitiamina/análogos & derivados , Animais , Etilenoglicol , Intubação Gastrointestinal , Masculino , Músculos/metabolismo , Ácidos Nicotínicos/farmacocinética , Oxitiamina/farmacocinética , Oxitiamina/farmacologia , Ratos , Ratos WistarRESUMO
We have compared the embryotoxic effect of aliphatic alcohols on antenatal embryogenesis of rats and the activity of alcohol dehydrogenase (EC.1.1.1.1) in embryonic hepatocytes. The embryotoxic activity of the used alcohols in equitoxic doses (assessed as the lethal effect) showed some dependence on their chemical structure. Earlier it has been demonstrated that there is a similar dependence for the mutagenic effects of the alcohols at the chromosomal level. All tested compounds, with the exception of decanol, distinctly retarded the development, but did not exert any teratogenic action. The administration of aliphatic alcohols also led to a significant decrease in the activity of alcohol dehydrogenase in fetal hepatocytes.
Assuntos
Álcoois/toxicidade , Embrião de Mamíferos/efeitos dos fármacos , Álcool Desidrogenase/efeitos dos fármacos , Álcool Desidrogenase/metabolismo , Animais , Perda do Embrião/induzido quimicamente , Feminino , Fígado/efeitos dos fármacos , Fígado/embriologia , Fígado/enzimologia , Placenta/efeitos dos fármacos , Gravidez , Efeitos Tardios da Exposição Pré-Natal , RatosAssuntos
Compostos de Benzil/normas , Tolueno/análogos & derivados , Poluentes Químicos da Água/análise , Poluentes da Água/análise , Abastecimento de Água/normas , Animais , Compostos de Benzil/administração & dosagem , Compostos de Benzil/análise , Compostos de Benzil/toxicidade , Relação Dose-Resposta a Droga , Feminino , Morte Fetal/induzido quimicamente , Masculino , Concentração Máxima Permitida , Camundongos , Ratos , Imobilizantes dos Espermatozoides , Motilidade dos Espermatozoides/efeitos dos fármacos , Motilidade dos Espermatozoides/fisiologia , Tolueno/análise , Tolueno/toxicidade , Ucrânia , Poluentes Químicos da Água/toxicidade , Abastecimento de Água/análiseRESUMO
The 7 day-long intragastric administration of ethanol and ethyleneglycol in a dose of 1/3 DL50 was studied for its effect on the circadian variations of the aspartate aminotransferase activity (AST, EC 2.6, 1.1) in the liver, brain, myocardium and kidney of male rats. The ethanol and ethylene glycol administration reduced the mean circadian enzymic activity in the above organs. Moreover, ethanol significantly reduced the amplitude of circadian variations of the AST activity in the liver, brain and kidney, while ethylene glycol--in the liver, myocardium and kidney.