Treatment of infections of the spine.

Spinal infection may involve the vertebrae, the intervertebral discs, and the adjacent intraspinal and paraspinal soft tissues. It often starts with subtle and insidious clinical signs and symptoms and may development to a debilitating and even life threatening disease. Spinal infections occur with increasing incidence and are nowadays a disease of everyday's practice for physicians treating spinal disorders. Traditionally, conservative treatment consisting of antibiosis and immobilisation is considered the first tier therapy. However, due to a considerably high rate of vertebral column instability or neurological impairment caused by the infected tissue, comprehensive experience with surgical measures have been acquired over the last decades. Thanks to tremendous improvements of surgical implants and techniques, surgical treatment has already begun to challenge conservative treatment to eventually become the first tier therapy for spinal infections in the future. This review seeks to give an overview of epidemiology, pathogenesis, diagnostic evaluation, and current nonsurgical and surgical therapy of spinal infections on the basis of the existing literature, which consists largely of retrospectively acquired data of single-centre experience with sample sizes of less than 100 patients treated with individually defined indications and treatment algorithms, and followed with various outcome parameters.

Posterior instrumentation of the cervical spine with a versatile modular fixation system.

OBJECT: To study the feasibility/suitability of posterior instrumentation of the entire cervical and upper thoracic spine (C0-Th5) for a broad spectrum of indications in a predominantly old-aged and co-morbid patient population using a novel occipito-cervico-thoracic system. METHODS: 54 consecutive patients (m=31, f=23, median age 63) with degenerative, neoplastic, traumatic, or infectious diseases were treated over a period of 29 months. Primary posterior as well as secondary posterior approaches after anterior instrumentation were used. Clinical and radiographic data was acquired prospectively using standard scales at pre-defined time intervals. RESULTS: On average 3 segments (range: 1-6) were bridged without significant intraoperative complications. In 30 cases a posterior decompression was additionally performed. Nine of 315 implanted screws were defined as suboptimal, leading to operative revision in 5 cases. During the follow-up interval (9+/-1.1 months, range: 3-25) patients showed a statistically significant improved mobility (Karnofsky score: 58+/-3 [pre] compared to 75+/-3 [post]) with improved mental and physical health (SF-36 health survey: mental component 44 [pre] to 51 [post], physical component 34 [pre] to 44 [post]) and less subjective pain (VAS: 3.9+/-0.3 [pre] to 0.5+/-0.1 [post]). All patients remained neurologically stable or improved after operation except two, who transiently deteriorated by one Nurick grade. Only one dislocation and no breakages of the implanted hardware were seen, and no significant secondary loss of spinal alignment was observed. CONCLUSIONS: Posterior instrumentation of the entire cervical and upper thoracic spine with the novel occipito-cervico-thoracic system has been shown to be safe, convenient and effective. The anterior approach in high-risk patients can thus be avoided, and the approach provides substantial additional stability to multi-level anterior constructs.