Closed circuit MR compatible pulsatile pump system using a ventricular assist device and pressure control unit.

The aim of this study was to evaluate the performance of a closed circuit MR compatible pneumatically driven pump system using a ventricular assist device as pulsatile flow pump for in vitro 3D flow simulation. Additionally, a pressure control unit was integrated into the flow circuit. The performance of the pump system and its test-retest reliability was evaluated using a stenosis phantom (60% lumen narrowing). Bland-Altman analysis revealed a good test-retest reliability (mean differences = -0.016 m/s, limits of agreement = ±0.047 m/s) for in vitro flow measurements. Furthermore, a rapid prototyping in vitro model of a normal thoracic aorta was integrated into the flow circuit for a direct comparison of flow characteristics with in vivo data in the same subject. The pneumatically driven ventricular assist device was attached to the ascending aorta of the in vitro model to simulate the beating left ventricle. In the descending part of the healthy aorta a flexible stenosis was integrated to model an aortic coarctation. In vivo and in vitro comparison showed significant (P = 0.002) correlations (r = 0.9) of mean velocities. The simulation of increasing coarctation grade led to expected changes in the flow patterns such as jet flow in the post-stenotic region and increased velocities.

Dampening of blood-flow pulsatility along the carotid siphon: does form follow function?

BACKGROUND AND PURPOSE: The tortuous distal part of the ICA may have an attenuating effect on pulsatile arterial flow. We investigated local arterial blood flow patterns in the ICA proximal and distal to the carotid siphon to detect quantitative waveform changes. MATERIALS AND METHODS: Arterial flow patterns were analyzed by using flow-sensitized 4D PC MR imaging (time-resolved 3D PCMR) at 3T in 17 healthy volunteers. Time-resolved blood flow velocities were extracted from the source data at the C4 and C7 segments of the ICA. PI, RI, and PA were calculated by using time-resolved flow volume. A linear mixed-effects model was applied to compare values at C4 and C7. Furthermore, 3D blood flow visualization was performed for all 34 ICAs. RESULTS: PI, RI, and PA were significantly lower at the distal C7 segment compared with the proximal C4 segment of the ICA (P < .0001). Helical flow patterns were observed in 5 ICAs of 4 subjects. CONCLUSIONS: Arterial flow patterns showed a significant reduction in PI, RI, and PA when compared distal to proximal to the carotid siphon. The observed attenuation of flow pulsatility is most likely related to the contorted shape of the distal ICA and may bear a protective effect for downstream cerebral vasculature.

3D blood flow characteristics in the carotid artery bifurcation assessed by flow-sensitive 4D MRI at 3T.

To determine three-dimensional (3D) blood flow patterns in the carotid bifurcation, 10 healthy volunteers and nine patients with internal carotid artery (ICA) stenosis > or =50% were examined by flow-sensitive 4D MRI at 3T. Absolute and mean blood velocities, pulsatility index (PI), and resistance index (RI) were measured in the common carotid arteries (CCAs) by duplex sonography (DS) and compared with flow-sensitive 4D MRI. Furthermore, 3D MRI blood flow patterns in the carotid bifurcation of volunteers and patients before and after recanalization were graded by two independent readers. Blood flow velocities measured by MRI were 31-39% lower than in DS. However, PI and RI differed by only 13-16%. Rating of 3D flow characteristics in the ICA revealed consistent patterns for filling and helical flow in volunteers. In patients with ICA stenosis, 3D blood flow visualization was successfully employed to detect markedly altered filling and helical flow patterns (forward-moving spiral flow) in the ICA bulb and to evaluate the effect of revascularization, which restored filling and helical flow. Our results demonstrate the feasibility of flow-sensitive 4D MRI for the quantification and 3D visualization of physiological and pathological flow patterns in the carotid artery bifurcation.

Quantitative 2D and 3D phase contrast MRI: optimized analysis of blood flow and vessel wall parameters.

Quantification of CINE phase contrast (PC)-MRI data is a challenging task because of the limited spatiotemporal resolution and signal-to-noise ratio (SNR). The method presented in this work combines B-spline interpolation and Green's theorem to provide optimized quantification of blood flow and vessel wall parameters. The B-spline model provided optimal derivatives of the measured three-directional blood velocities onto the vessel contour, as required for vectorial wall shear stress (WSS) computation. Eight planes distributed along the entire thoracic aorta were evaluated in a 19-volunteer study using both high-spatiotemporal-resolution planar two-dimensional (2D)-CINE-PC ( approximately 1.4 x 1.4 mm(2)/24.4 ms) and lower-resolution 3D-CINE-PC ( approximately 2.8 x 1.6 x 3 mm(3)/48.6 ms) with three-directional velocity encoding. Synthetic data, error propagation, and interindividual, intermodality, and interobserver variability were used to evaluate the reliability and reproducibility of the method. While the impact of MR measurement noise was only minor, the limited resolution of PC-MRI introduced systematic WSS underestimations. In vivo data demonstrated close agreement for flow and WSS between 2D- and 3D-CINE-PC as well as observers, and confirmed the reliability of the method. WSS analysis along the aorta revealed the presence of a circumferential WSS component accounting for 10-20%. Initial results in a patient with atherosclerosis suggest the potential of the method for understanding the formation and progression of cardiovascular diseases.

3D MR flow analysis in realistic rapid-prototyping model systems of the thoracic aorta: comparison with in vivo data and computational fluid dynamics in identical vessel geometries.

The knowledge of local vascular anatomy and function in the human body is of high interest for the diagnosis and treatment of cardiovascular disease. A comprehensive analysis of the hemodynamics in the thoracic aorta is presented based on the integration of flow-sensitive 4D MRI with state-of-the-art rapid prototyping technology and computational fluid dynamics (CFD). Rapid prototyping was used to transform aortic geometries as measured by contrast-enhanced MR angiography into realistic vascular models with large anatomical coverage. Integration into a flow circuit with patient-specific pulsatile in-flow conditions and application of flow-sensitive 4D MRI permitted detailed analysis of local and global 3D flow dynamics in a realistic vascular geometry. Visualization of characteristic 3D flow patterns and quantitative comparisons of the in vitro experiments with in vivo data and CFD simulations in identical vascular geometries were performed to evaluate the accuracy of vascular model systems. The results indicate the potential of such patient-specific model systems for detailed experimental simulation of realistic vascular hemodynamics. Further studies are warranted to examine the influence of refined boundary conditions of the human circulatory system such as fluid-wall interaction and their effect on normal and pathological blood flow characteristics associated with vascular geometry.

Variable echo time imaging: signal characteristics of 1-M gadobutrol contrast agent at 1.5 and 3T.

Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In order to explore the performance of 1-M contrast agents such as Gd-Bt and its dependence on molecular environment and temperature, signal characteristics were analyzed for a series of increasing Gd-Bt concentrations for different temperature-controlled samples in water and human blood plasma. Relaxation times, relaxivities, and signal-concentration curves were assessed for several Gd-Bt concentrations in water at 20 degrees C and 37 degrees C and in plasma at 37 degrees C for 1.5T and 3T. Gd-Bt concentration influence on signal intensity (SI) could be effectively simulated and compared with experimental measurements as well as simulations with other contrast agents at realistic in vivo concentrations. Particular attention was given to T(2)- and T(*) (2)-induced losses at high concentrations, which annihilate benefits from T(1) shortening. Based on these findings, variable echo time (VTE) approaches with readout bandwidth varying with k-space position were explored in order to enhance the signal to noise performance of gradient echo imaging at high contrast agent concentrations. Results indicate the potential of VTE for imaging with increased SNR at high contrast agent concentrations.

[Flow-sensitive in-vivo 4D MR imaging at 3T for the analysis of aortic hemodynamics and derived vessel wall parameters]. / Die Analyse aortaler Hämodynamik und Gefässwandparameter mittels fluss-sensitiver in-vivo 4D-MRT bei 3 Tesla.

Modern phase contrast MR imaging at 3 Tesla allows the depiction of 3D morphology as well as the acquisition of time-resolved blood flow velocities in 3 directions. In combination with state-of-the-art visualization and data processing software, the qualitative and quantitative analysis of hemodynamic changes associated with vascular pathologies is possible. The 4D nature of the acquired data permits free orientation within the vascular system of interest and offers the opportunity to quantify blood flow and derived vessel wall parameters at any desired location within the data volume without being dependent on predefined 2D slices. The technique has the potential of overcoming the limitations of current diagnostic strategies and of implementing new diagnostic parameters. In light of the recent discussions regarding the influence of the wall shear stress and the oscillatory shear index on the genesis of arteriosclerosis and dilatative vascular processes, flow-sensitive 4D MRI may provide the missing diagnostic link. Instead of relying on experience-based parameters such as aneurysm size, new hemodynamic considerations can deepen our understanding of vascular pathologies. This overview reviews the underlying methodology at 3T, the literature on time-resolved 3D MR velocity mapping, and presents case examples. By presenting the pre- and postoperative assessment of hemodynamics in a thoracic aortic aneurysm and the detailed analysis of blood flow in a patient with coarctation we underline the potential of time-resolved 3D phase contrast MR at 3T for hemodynamic assessment of vascular pathologies, especially in the thoracic aorta.