Iron chelation effects on lipid peroxidation, inflammation and ventricular performance in a rat model of isoproterenol induced acute myocardial stress.

Acute cardiac pathologies represent one of the leading causes of death, while iron metabolism is recognized to be implicated in reactive oxygen species production, lipid peroxidation, and inflammation. The aim of the present study was to assess iron chelation effects in isoproterenol (ISO) induced acute cardiac stress. We divided male Wistar rats into preventive and secondary treatment groups, with the active arm consisting in deferiprone (DFP), a lipid permeable chelator. Mortality of ISO was 10-18.18% in both preventive and secondary groups. We analyzed serum and myocardial tissue parameters of inflammation, iron dynamics, and lipid peroxidation, accompanied by ultramicroscopy, histological, and ultrasound-derived parameters of left ventricular function. Results reveal that ISO-mediated lipid peroxidation and inflammation are alleviated by administration of DFP, with negligible effect on systemic ferroregulation dynamics and global ventricular function (as assessed by ultrasound). DFP administration after cardiovascular stress is associated with a decrease in lipid peroxidation and inflammation, without an improvement in gross left ventricular parameters.

[Surgical treatment of aorto-iliac atherosclerosis]. / Tratamentul chirurgical al bolii aterosclerotice aorto-iliace.

The occlusive aorto-iliac disease is the consequence of a diffuse atherosclerotic process aggravated by risk factors and existing co-morbidity. The treatment aims at correcting the risk factors, balancing and compensating the associated diseases, the surgical re-vascularization of the lower limbs (by pass, particular techniques for the aortic aneurysms, necessity interventions). Aortic and peripheral angiographic exploration is required for the establishment of surgical strategy. The lot studied includes 77 patients hospitalized in the period between 2000-2006 in the Surgery Clinic no. II, Cluj-Napoca. 33 cases had an obstruction of a single iliac artery. The bilateral affection has been present in 27 cases, while that of the terminal trunk of the aorta and of its bifurcation has been present in 17 cases. The most frequent intervention has been the aorto-bifemoral prosthesis, the prosthesis used being: Terom, Dacron and PTFE. The thrombendarterectomy was used as an independent method or associated with the by-pass. At the same time, the aortoiliac interventions were associated with aorto-inguinal bypass, crossover as well as disarticulations and amputations of toes. 26% of the 77 patients, had early post-surgery complications (hemorrhage, infection, the thrombosis of the graft). The re-vascularization failed in 3.8% of cases, a major amputation of the limb being necessary. 11 deaths (14.3%) were recorded which occurred as a result of systemic complications.