[Microsymbiocenosis of Codiella mollusks as a basis for symbiotic relations in the parasite-host system in opisthorchiasis].

The purpose of the first step of microparasitocenosis investigation was to study the microbiocenosis of the first intermediate hosts of O. felineus--prosobranch gastropods of the genus Codiella, as well as their habitats. Materials were collected in the Iryum River of the Ob-Irtysh basin. The microflora of mollusks, water, and soil from their habitats was examined. The predominant flora was Aeromonas species in the biocenosis of mollusks and Enterobacteriaceae in the microbiocenosis of the water basin and soil. Examination of the microbial communities in the mollusks and their habitats showed that the range of microbial populations of mollusks was wider in species composition as compared to the microbiocenosis of soil and water.

[Age-related features of colonic dysbiosis in Lamblia infestation].

The purpose of the investigation was to comparatively study and to define the specific features of intestinal microbiocenosis in patients with lambliasis in different age groups of children and adults. Characterizing the age-related features of microbiocenosis in Lamblia infestation showed differences in 3 age groups: children aged less than 7 years and those aged 8-14 years, and adults; there were no statistically significant differences in the characteristics of microbiocenosis between age groups I and II, as well as age groups IV and V. Intestinal microbiocenotic changes in Lamblia infestation were less evident in the 8-14-year-old children: grade 1 microbiological changes characterized by a decrease in the normal flora were most common.

[Age-related features of dysbiosis of large intestine].

AIM: To compare rate of detection of stage II-III intestinal dysbiosis with normal and decreased quantities of bacteria from Lactobacillus and Bifidobacterium families in different age groups. MATERIALS AND METHODS: Microflora of large intestine was studied in 600 persons of different ages with normal quantity or deficit of bacteria from Lactobacillus and Bifidobacterium families. RESULTS: Decrease of bifidobacteria level in structure of large intestine microflora increases rate of detection of opportunistic microorganisms--predominantly, bacteria from Klebsiella genus and Staphylococcus aureus. Decrease of lactobacilli level had lesser influence on rate of detection of opportunistic microorganisms. CONCLUSION: Results of bacteriologic studies of large intestine microbiocenosis demonstrate that intestinal microflora has its own characteristics in each age group.

[Biochemical parameters of hepatobiliary system functions in viral hepatitis or ixodes tick-borne borreliosis concurrent with chronic opisthorchiasis].

The biochemical parameters of hepatobiliary system functions were studied in patients with opisthorchiasis and concomitant diseases, such as chronic viral hepatitis concurrent with chronic opisthorchiasis, as well as Ixodes tick-borne borreliosis in the presence of the same invasion. Although the magnitude ofbiochemical changes is not great in chronic opisthorchiasis or chronic viral hepatitis, the concomitance of these two diseases were ascertained to result in pronounced abnormalities, by demonstrating the exhaustion of spare capacities of the hepatobiliary system in parasitic invasion (or viral infection). When opisthorchiasis was concurrent with Ixodes tickborne borreliosis, some parameters under study differed from those in the groups of patients with monoinfections. Variance analysis showed that chronic opisthorchiasis had a great impact on carbohydrate and lipid metabolisms (glucose and cholesterol levels). The findings suggest that the formation of stable host-parasite relationships in chronic opisthorchiasis alters human metabolic processes and their compensatory capabilities.