1.
Nat Biotechnol
; 33(8): 839-41, 2015 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26237515
RESUMO
Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to control cell behavior while avoiding potentially harmful genomic integration in therapeutic applications. We create post-transcriptional circuits using RNA-binding proteins, which can be wired in a plug-and-play fashion to create networks of higher complexity. We show that the circuits function in mammalian cells when encoded in modified mRNA or self-replicating RNA.