Artificial intelligence-based prognostic model accurately predicts the survival of patients with diffuse large B-cell lymphomas: analysis of a large cohort in China.

BACKGROUND: Diffuse large B-cell lymphomas (DLBCLs) display high molecular heterogeneity, but the International Prognostic Index (IPI) considers only clinical indicators and has not been updated to include molecular data. Therefore, we developed a widely applicable novel scoring system with molecular indicators screened by artificial intelligence (AI) that achieves accurate prognostic stratification and promotes individualized treatments. METHODS: We retrospectively enrolled a cohort of 401 patients with DLBCL from our hospital, covering the period from January 2015 to January 2019. We included 22 variables in our analysis and assigned them weights using the random survival forest method to establish a new predictive model combining bidirectional long-short term memory (Bi-LSTM) and logistic hazard techniques. We compared the predictive performance of our "molecular-contained prognostic model" (McPM) and the IPI. In addition, we developed a simplified version of the McPM (sMcPM) to enhance its practical applicability in clinical settings. We also demonstrated the improved risk stratification capabilities of the sMcPM. RESULTS: Our McPM showed superior predictive accuracy, as indicated by its high C-index and low integrated Brier score (IBS), for both overall survival (OS) and progression-free survival (PFS). The overall performance of the McPM was also better than that of the IPI based on receiver operating characteristic (ROC) curve fitting. We selected five key indicators, including extranodal involvement sites, lactate dehydrogenase (LDH), MYC gene status, absolute monocyte count (AMC), and platelet count (PLT) to establish the sMcPM, which is more suitable for clinical applications. The sMcPM showed similar OS results (P < 0.0001 for both) to the IPI and significantly better PFS stratification results (P < 0.0001 for sMcPM vs. P = 0.44 for IPI). CONCLUSIONS: Our new McPM, including both clinical and molecular variables, showed superior overall stratification performance to the IPI, rendering it more suitable for the molecular era. Moreover, our sMcPM may become a widely used and effective stratification tool to guide individual precision treatments and drive new drug development.

Efficacy and safety of the combined use of ipilimumab and nivolumab for melanoma patients with brain metastases: a systematic review and meta-analysis.

CONTEXT: Immune checkpoint inhibitors have advanced immunotherapy for melanoma patients.Objective: This study evaluates efficacy and safety of ipilimumab and nivolumab combination (IN) for melanoma brain metastases (MBM) patients. MATERIALS AND METHODS: Literature search was conducted in electronic databases and studies were included if they reported efficacy and safety of IN in MBM patients or prognostic information related to brain metastases. Outcomes evaluated were objective response rate (ORR), complete remission/stable disease/progressive disease rates, progression-free survival (PFS), overall survival (OS), incidence rates of adverse events, and hazard ratios of disease progression or mortality between IN-treated patients with and without brain metastasis. RESULTS: Intracranial ORR was higher in IN-treated MBM patients than with control therapies (nivolumab or ipilimumab plus fotemustine). IN treatment led to longer PFS and OS in than control treatments. Five-year OS of IN-treated MBM patients was up to 51% compared to 34% for nivolumab. Outcomes were better for treatment naïve and asymptomatic patients. Whereas many studies reported significantly higher mortality or progression risk with IN treatment in MBM patients compared to non-MBM melanoma patients, many others did not find this risk significant. Incidence of grade 3/4 adverse events in IN-treated MBM patients was: diarrhea or colitis (16%), hepatitis (15%), rash (8%), increased alanine transaminase (8%), increased aspartate aminotransferase (7%), increased lipase (6%), increased amylase (4%), fatigue (3%), hypophysitis (2%), pneumonitis (2%), headache (2%), nausea or vomiting (1%), and neutropenia (1%). CONCLUSION: IN is an efficacious and safer treatment option for MBM patients, especially for asymptomatic and treatment naïve patients.

Improved multi-agent controllability processing technique based on equitable partition.

In this paper, we study the controllability of multi-agent systems by equitable partition and automorphism. For the case that cells are incompletely connected outside but completely connected inside, a necessary condition for controllability is given from the perspective of the rank of connection matrix. For the case of multiple cells being completely connected outside and incompletely connected inside, in terms of the eigenvalues and eigenvectors of L and Lπ, several sufficient and necessary conditions for controllability are presented. Once the quotient graph is controllable under single input or all nodes in nontrivial cells are leaders, the lower bound of controllable subspace is determined. Finally, we give the gap between the necessary condition and the sufficient condition for controllability from the aspect of equitable partition. One highlight of the results in this paper is that we show sufficient conditions to judge controllability by equitable partition and automorphism, which, for specific cases, provides one method that how to break through the defect that equitable partition can only obtain necessary conditions.

Deaf and hearing children: A comparison of face perception.

Deaf and hearing adults perceive faces differently. This study investigates whether these differences are acquired during childhood development. We characterized facial perception in deaf and hearing children aged 7-17 using a perceptual discrimination task. Configural and featural information was manipulated in the eye and mouth facial regions. Participants were asked whether two faces presented simultaneously were different. Deaf and hearing children performed better in featural than configural discriminations and in mouth than eye discriminations. Compared with children with typical hearing, deaf children performed better in featural and mouth judgments but had longer reaction times with strongest effects at 7-8 and 13-14 years old. Type and location contributed jointly in deaf children's face perception with different configural but similar featural discriminations in mouth and eye locations. However, children with typical hearing showed different featural and configural judgments in both locations. Thus, featural and configural information effects on location processing differ between the two groups.

Safety and efficacy analysis of chemoradiotherapy/radiotherapy combined with nimotuzumab for treating unresectable oesophageal squamous cell carcinoma in elderly patients: a retrospective analysis.

OBJECTIVE: To investigate the safety and efficacy of chemoradiotherapy or radiotherapy combined with nimotuzumab in the treatment of unresectable oesophageal squamous cell carcinoma (ESCC) in elderly patients. METHODS: This study retrospectively analysed 54 cases of elderly patients (aged over 70 years) with unresectable ESCC in our centre between December 2016 and November 2019. The patients were treated with a radiation dose of 50-61.6 Gy (25-30 fractions) combined with nimotuzumab for targeted therapy with or without chemotherapy according to each patient's condition. The patients were observed for quality of life, safety, side effects and survival before and after the treatment. RESULTS: Among the 54 patients, 26 were treated with nimotuzumab combined with chemoradiotherapy and 28 were treated with nimotuzumab combined with radiotherapy. Toxicities were mainly oesophagitis (≥ Grade 2, 38.9%), myelosuppression (≥ Grade 3, 24.1%) and hypoproteinaemia (any grade, 94.4%). The rates of complete response, partial response, disease stability and disease progression were 11.1% (6/54), 81.5% (44/54), 3.7% (2/54) and 3.7% (2/54), respectively, and the overall objective response rate was 92.6% (50/54). The median follow-up time was 35.1 months, and the 1- and 2-year overall survival (OS) and progression-free survival (PFS) rates were 61.1% (1 year OS) and 35.2% (2 year OS), 42.6% (1 year PFS) and 16.7% (2 year PFS), respectively. The median OS and PFS rates were 16.0 and 10.0 months, respectively. CONCLUSION: Nimotuzumab combined with chemoradiotherapy or radiotherapy was well tolerated in elderly patients with unresectable ESCC. This combination can achieve a good treatment response and enhance survival.

The influence of the literacy environment on children's writing development in Chinese.

The present study investigated the influence of literacy environment on the performance of writing narratives for primary school students. Two hundred and fifty Chinese children participated in this study. There were 146 third graders (71 boys and 75 girls) and 104 fifth graders (53 boys and 51 girls). Results showed that children's writing abilities differed at the word level and sentence level between third grade and fifth grade. Formal literacy experience (parent teaching of characters) predicted the writing performance of third graders, while informal literacy experience (the visiting frequency of various places) predicted the writing performance of fifth graders. After controlling the effect of reading efficiency on the writing skills, the prediction of formal and informal literacy experiences on the writing performance remained. The results suggest the importance of formal and informal literacy experiences on the writing development of primary school students.

A New Method to Assist Decision-Making of Water Environmental Emergency in Expressway Region.

Water environmental emergency (WEE) in expressway region is a special kind of risk event with several characteristics, such as rarity, unconventionality, and harmfulness. The emergency decision-making (EDM) features, procedures, and methods are considerably different from the general decision-making problems. EDM quality is directly related to the timely implementation of a reasonable emergency plan. Therefore, methods should be developed to respond to emergencies immediately and scientifically and minimize the damage to water environment. This work introduces risk source identification and emergency classification and develops an emergency decision model based on scenario retrieval and case-based reasoning, according to the existing EDM model and characteristics of WEE in expressway region. The proposed method is validated through case analysis of Daguang expressway in China. This method provides an effective solution for EDM of WEEs in expressway region. The emergency measures can be implemented quickly and effectively after the occurrence of water environmental emergencies to control pollution events, provide scientific and feasible action guides for emergency processes, and enrich the case base of decision-making systems.

Redefine the Role of Proton Beam Therapy for the Locally-Advanced Non-Small Cell Lung Cancer Assisting the Reduction of Acute Hematologic Toxicity.

Purpose: To investigate the potential clinical benefit of utilizing intensity-modulated proton therapy (IMPT) to reduce acute hematologic toxicity for locally advanced non-small cell lung cancer (LA-NSCLC) patients and explore the feasibility of a model-based patient selection approach via the normal tissue complication probability (NTCP). Methods: Twenty patients with LA-NSCLC were retrospectively selected. Volumetric modulated arc photon therapy (VMAT) and IMPT plans were generated with a prescription dose of 60 Gy in 30 fractions. A wide range of cases with varied tumor size, location, stations of metastatic lymph nodes were selected to represent the general cancer group. Contouring and treatment planning followed RTOG-1308 protocol. Doses to thoracic vertebral bodies (TVB) and other organ at risks were compared. Risk of grade ≥ 3 acute hematologic toxicity (HT3+) were calculated based on the NTCP model, and patients with a reduction on NTCP of HT3+ from VMAT to IMPT (△NTCP_HT3+) ≥ 10% were considered to 'significantly benefit from proton therapy.' Results: Compared to VMAT, IMPT significantly reduced the dose to the TVB, the lung, the heart, the esophagus and the spinal cord. Tumor distance to TVB was significantly associated with △NTCP _HT3+ ≥ 10%. For the patients with tumor distance ≤ 0.7 cm to TVB, the absolute reduction of dose (mean, V30 and V40) to TVB was significantly lower than that in patients with tumor distance > 0.7 cm. Conclusion: IMPT decreased the probability of HT3+ compared to VMAT by reducing the dose to the TVB in LA-NSCLC patients. Patients with tumor distance to TVB less than 0.7 cm are likely to benefit most from proton over photon therapy.

Impact of drinking Chinese green tea on postoperative short outcomes for gastric cancer: a randomized controlled trial.

BACKGROUND: Early intake after surgery can decrease postoperative ileus. Several studies show coffee can stimulate bowel activity and be safe in patients after elective colectomy, mainly due to caffeine. It was postulated that drinking Chinese green tea as rich caffeine beverage after subtotal distal gastrectomy accelerates postoperative recovery in patients. METHOD: This was a single-centre parallel open-label randomized trial. Patients with gastric cancer undergoing robotic or laparoscopic subtotal gastrectomy were randomly allocated to receive drinking Chinese green tea (GT group) or potable water (PW group) after surgery. The primary endpoint was the time to gastrointestinal function recovery and tolerance of solid food, and the secondary endpoints included the incidence of postoperative complications, symptoms of postoperative adverse reaction, length of stay, pain as assessed by analgesic consumption and a visual analogue scale, and fatigue as assessed by a fatigue score model. RESULTS: A total of 80 patients were recruited, 40 to each group. Patient characteristics were similar in both groups. The GT group showed significantly shorter time to gastrointestinal function recovery compared with PW group to first flatus (47.23 ± 13.46 vs. 76.96 ± 20.35, P < 0.001), first bowel motion (78.70 ± 25.77 vs. 125.76 ± 36.25, P < 0.001) and tolerance of solid food (62.20 ± 16.15 vs. 98.66 ± 20.15, P < 0.001). CONCLUSION: Drinking Chinese green tea after robotic or laparoscopic subtotal gastrectomy is safe and promotes postoperative recovery of gastrointestinal function, also was an add method with strengthening analgesia and anti-inflammatory effect in the presence of the Enhance Recovery After Surgery (ERAS) program. Registration number: ChiCTR1800018294 ( http://www.chictr.org.cn ).

Strategy for Achieving Long-Wavelength Near-Infrared Luminescence of Diimineplatinum(II) Complexes.

Although many strategies have been used to help design effective near-infrared (NIR) luminescent materials, it is still a huge challenge to realize long-wavelength NIR luminescence of diimineplatinum(II) complexes in the solid state. Herein, we have successfully achieved long-wavelength NIR luminescence of a family of diimineplatinum(II) complexes based on a new strategy that combines a one-dimensional (1D) "Pt wire" structure with the electronic effect of the substituent. The structures of six solvated diimineplatinum(II) complexes based on 4,4-dichloro-2,2'-bipyridine or 4,4-dibromo-2,2'-bipyridine and 4-substituted phenylacetylene ligands have been determined, namely, 1·1/2toluene, 2·1/2THF, 3·1/8toluene, 4·1/2THF, 5·1/8CH2Cl2, and 6·1/4toluene. All of them crystallize in the monoclinic space group C2/c or C2/m and stack in the 1D "Pt wire" structure. In the solid state, six complexes exhibited unusual long-wavelength metal-metal-to-ligand charge-transfer luminescence that peaked at 984, 1044, 972, 990, 1022, and 935 nm, respectively. Interestingly, 2·1/2THF has the shortest Pt···Pt distance and the longest emission wavelength among the six complexes. As far as we know, the luminescence of 2·1/2THF at 1044 nm is the longest emission wavelength among known diimineplatinum(II) complexes. Systematic studies revealed that good molecular planarity, suitable substituent position, weak hydrogen-bond-forming ability of the substituents, appropriate molecular bending, and weakening of the interaction between solvated molecules and platinum molecules are conducive to the construction of a 1D "Pt wire" structure of the diimineplatinum(II) complex. Furthermore, the emission energy of the complex is mainly determined by the strength of the Pt-Pt interaction and electronic effect of the substituent.

The development of brain functional connectome during text reading.

Reading is an important skill for human beings to obtain information, whose acquisition is a major learning task for children. Especially, compared with single word reading, text reading requires an integration of multiple cognitive processes, which makes its underlying neural developmental mechanism not only extremely complicated but also remained poorly understood. Employing the graph theory analysis method, the present study explored the development of brain in the context of story reading from the perspective of connectomics. Forty-two primary school students and thirty-two adults read the stories in the functional magnetic resonance imaging (fMRI) experiment. We found that compared with children, adults had increased connectivity strength, nodal degree, and modular interactions for vision-related and semantics-related brain regions while decreased connectivity strength, nodal degree, and modular interactions for phonology-related brain regions. Brain-behavior association analysis suggested that the transmission to vision-related brain circuits would enhance the reading performance in adults, whereas phonology-related brain circuits played important roles in children's reading before they develop into fluent readers. Collectivity, we highlight a shift from reliance on phonology-related networks to semantics-related and vision-related networks with age for text reading, which provides insights into the underlying neural signature of developmental cognitive mechanisms.

Effects of socioeconomic status in predicting reading outcomes for children: The mediation of spoken language network.

The present longitudinal study investigated the effects of early childhood socioeconomic status on language-related resting-state functional connectivity and reading outcome in adolescence. Seventy-nine children participated in this study. Socioeconomic status was measured via parent questionnaire measuring parental education and family income at 1 month. At age 14, resting-state fMRI data and reading-related behavioral data of the children were collected. Resting-state functional connectivity (RSFC) analysis was performed based on four regions of interest, including the left inferior frontal gyrus (L.IFG), left anterior superior temporal gyrus (L.aSTG), left posterior superior temporal gyrus (L.pSTG) and right anterior superior temporal gyrus (R.aSTG). Significant associations were found between parental education and the language-related RSFC, including the RSFC of L.IFG-L.aSTG and the RSFC of L.aSTG-L.pSTG, while no association was found between family income and language-related RSFC. Furthermore, the parental education-associated functional connectivity patterns (i.e., L.IFG-L.aSTG and L.aSTG-L.pSTG) were found to be positively correlated with children's reading skills (word list reading and sentence reading fluency). Finally, path analyses indicated that the intrinsic brain connectivity between L.aSTG and L.pSTG influenced the relationship between parental education and children's reading outcomes.

Visual Search in Chinese Children With Attention Deficit/Hyperactivity Disorder and Comorbid Developmental Dyslexia: Evidence for Pathogenesis From Eye Movements.

In this study, a visual search task was conducted on children with comorbid attention deficit/hyperactivity disorder (ADHD) and developmental dyslexia (DD), children with pure ADHD, and typically developing children to explore the pathogenesis of comorbidity between ADHD and DD. Participants searched for the target character from five characters in each trial during the task. The distractors included orthographically similar characters, homophones, unrelated characters, and characters of a different color (i.e., red). Results showed that the clinical groups produced longer first fixation duration than the control group in all types of distractors. Children with ADHD comorbid DD were also more susceptible to characters with the distracting red color in gaze duration and total viewing time than were children with pure ADHD and healthy controls. The implication of comorbidity (ADHD + DD) on the pathogenesis was discussed. These results may be helpful for the diagnosis and treatment of ADHD with comorbid DD.

Children's neurodevelopment of reading is affected by China's language input system in the information era.

Communications through electronic devices require knowledge in typewriting, typically with the pinyin input method in China. Yet, the over utilization of the pronunciation-based pinyin input method may violate the traditional learning processes of written Chinese, which involves abundant visual orthographic analysis of characters and repeated writing. We used functional magnetic resonance imaging to examine the influence of pinyin typing on reading neurodevelopment of intermediate Chinese readers (age 9-11). We found that, relative to less frequent pinyin users, more frequent pinyin users showed an overall weaker pattern of cortical activations in the left middle frontal gyrus, left inferior frontal gyrus, and right fusiform gyrus in performing reading tasks. In addition, more frequent pinyin typists had relatively less gray matter volume in the left middle frontal region, a site known to be crucial for Chinese reading. This study demonstrates that Chinese children's brain development in the information era is affected by the frequent use of the pinyin input method.

Influences of the early family environment and long-term vocabulary development on the structure of white matter pathways: A longitudinal investigation.

In the present longitudinal study, we investigated the joint effect of early family factors and long-term vocabulary development on the structure of reading-related white matter pathways in adolescents. Seventy-nine children participated in this study. Family environment was measured via parental questionnaire between age 1 and age 3. From age 4 to age 10, children's vocabulary skills were tested annually. At age 14, diffusion tensor imaging data of the children were collected. Using individual-based tractography, 10 reading-related tracts of the two hemispheres were delineated. Different family factors were found to be correlated with different pathways: Age of literacy exposure was correlated with fractional anisotropy of the direct segment of the left arcuate fasciculus, while an association trend was found between early family socioeconomic status and fractional anisotropy of the left inferior frontal occipital fasciculus. Further regression analyses showed that the age of literacy exposure modulated the relationships between vocabulary development and the structure of the left arcuate fasciculus. Specifically, in the earlier literacy exposure group, no association was found between vocabulary development and the strength of the arcuate fasciculus, whereas in the later literacy exposure group, significant associations were found between vocabulary development and the strength of the arcuate fasciculus.

The Antibacterial Activity and Mechanism of Chlorogenic Acid Against Foodborne Pathogen Pseudomonas aeruginosa.

Chlorogenic acid (CA), an ester of caffeic acid, is a major phenolic compound in herbs. The antimicrobial activity of CA against Pseudomonas aeruginosa P1, a foodborne pathogen, was investigated in this study. To understand how CA injured target cells, the influence of CA on cell morphology was assessed. A sunken cell surface and detachment of outer membrane components in P. aeruginosa P1 were observed after being treated by CA. Following this, the intracellular membrane permeability and the content of lipopolysaccharide (LPS), a main component of outer membrane, were determined. The release of intracellular protein and ATP from P. aeruginosa P1 indicated that CA increased intracellular membrane permeability and resulted in the leakage of intracellular materials. The uptake of propidium iodide, a compromised cell membrane nucleic acid stain, further demonstrated that CA acted on the intracellular membrane. CA resulted in the decrease of LPS contents of P. aeruginosa P1, which supported the detachment of outer membrane. CA also downregulated the expression of major genes in LPS biosynthesis, suggesting that CA may inhibit intracellular metabolism of P. aeruginosa P1 cells. Thus, CA increased the intracellular membrane permeability, induced the exfoliation of outer membrane, and disturbed the intracellular metabolism. Damage of intracellular and outer membranes as well as disruption of cell metabolism resulted in cell death eventually. The finding suggested that CA has the potential to be developed as a preservative to control P. aeruginosa-associated foodborne diseases.

Alternating-color words influence Chinese sentence reading: Evidence from neural connectivity.

In order to investigate how language and attention systems are affected by word boundary information during reading, we conducted a functional magnetic resonance imaging (fMRI) experiment in which text-color in naturally unspaced Chinese sentences were systematically manipulated in three experimental conditions, that is, text-color alternation consistent or inconsistent with word boundary (i.e., alternating-color word and non-word conditions), as well as a mono-color baseline condition. Twenty college students (14 females; 23.1 years old) were required to silently read 72 sentences during fMRI scanning. We found that the conditions of word boundary modulated the brain connections between the visual word form area (VWFA) and dorsal attention regions, and between the VWFA and language-related regions. These results suggest that the coordination between the VWFA and dorsal attention regions plays an important role in grouping characters and guiding the saccade according to perceptual grouping based on color, and that the connection between VWFA and MTG could be the neural mechanism of lexical access during Chinese text reading.

Facile and Equipment-Free Data Encryption and Decryption by Self-Encrypting Pt(II) Complex.

Luminescence switching materials are vital to various data security-related techniques, including data encryption-decryption. Here, we report a family of pseudopolymorphs based on a diimine-platinum(II) complex, Pt(Me3SiC≡CbpyC≡CSiMe3)(C≡CC6H4Br-3)2 (1), and systematically studied the influence of stacking modes on luminescence switching behaviors. Upon exposure to heat or tetrahydrofuran vapor, these pseudopolymorphs exhibit unusual stacking mode-intervened luminescence switching (SMILS) property that non-columnar and quasi-columnar pseudopolymorphs undergo single- and multi-step conversion processes, respectively, to the same non-columnar products. Systematic studies revealed that the unique SMILS behavior is caused by the existence of stable intermediate products as well as different conversion processes of pseudopolymorphs with distinct stacking modes. Such a new property leads to the self-encryption function of 1, which is very important for improving the existing data encryption-decryption technique. On this basis, we developed a facile, reusable, equipment-free technique with 1 as the only starting material and realized data encryption-decryption successfully.